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University of Huddersfield research in physical organic chemistry has delivered economic, industrial and societal benefits. It has led to process improvements in chemical manufacturing, most notably in the optimisation of the synthesis of antisense oligonucleotides and in the use of liquid ammonia as a solvent. It has also led to the development of new inhibitors of bacterial β-lactamases for use as antibacterials. The research team's expertise has been reflected in the success of IPOS (Innovative Physical Organic Solutions), a unit established in 2006 to carry out research in process and other areas of chemistry for the chemical industry. IPOS expanded significantly from 2009 to 2013 and has now collaborated with more than 150 companies, many of them based in Yorkshire/Humberside where regeneration is critically dependent on the success of new, non-traditional, high-technology firms and industries. Through these collaborative projects, IPOS has contributed to the growth and prosperity of both regional and national industry.
In 2012, it is estimated the $145bn was invested in solar photovoltaic technology. Dye-Sensitized Solar Cells (DSC) are expected to play an increasing role in renewable energy generation over the next decade and beyond, but several practical issues need to be overcome to facilitate large-scale economic production. Fundamental research at Bangor has laid the ground for collaborative work with industry which has overcome several of the key production constraints in their manufacture, increasing production speed and efficiency and substantially reducing costs. As a result, we have developed a Technology Roadmap with a major multinational partner (TATA) which has led to significant investment in plant and to the production of pilot products in the form of photovoltaic roofs, currently undergoing outdoor testing.
The pioneering work of Steven Ley on polymer-supported reagents and continuous-flow reaction technology has helped change the way we achieve cleaner chemical processes. The concepts and techniques invented in Cambridge allow more sustainable processes to be developed, with concomitant reduction in purification steps, shorter reaction times and diminished solvent usage. The work has led to a spin-out company (Reaxa), seeded the creation of a number of other companies, and resulted in the development of several devices for continuous flow synthesis that are now commercially available via Mettler-Toledo (USA) and Cambridge Reactor Design (UK). This technology is having an impact in industry, with continuous flow processing increasingly being used for full-scale commercial production.
The vulnerability of both military and civilian infrastructure to the threat of terrorist activity has highlighted the need to improve its survivability, and this poses a significant design challenge to engineers. Research work at Imperial has led to the development of novel constitutive relationships for polymeric materials coupled to novel analysis procedures; software algorithms for effective simulations of blast and impact events; and enhanced experimental testing methods allowing a fundamental understanding of the structures. According to Dstl, this body of research has `unquestionably improved the security and effectiveness of the UK armed forces operating in hostile environments abroad as well as the safety of citizens using metropolitan infrastructure within the UK'. The techniques have been applied to vehicles and UK infrastructure, including for high profile events, such as the 2012 Olympics.
Durham selective direct fluorination methodology using fluorine gas has been scaled up by F2 Chemicals Ltd to supply the Pfizer company with multi-tonne quantities of a key pharmaceutical intermediate used in the synthesis of V-Fend (voriconazole). This antifungal agent has achieved global sales of $4.65bn from 2008-present and is used extensively for the treatment of invasive pulmonary aspergillosis. Multi-channel continuous flow gas/liquid microreactor technology for direct fluorination was licensed to the Asahi Glass Co (Japan) and other transformations enabled by fluorine gas are being exploited by a DU spin-out company, Brock Fine Chemicals Ltd.
Diffusion bonding (DB) is well-known for producing structured materials with fine scale features and is a critical technology for high efficiency reactors, e.g. heat exchangers and fuel cells, but currently equipment is slow and expensive (and there are size limitations to the `assemblies' that can be built). The University has researched and developed, with industry partners, a rapid affordable diffusion bonding (ADB) process involving direct heating to provide appropriate temperature and stress states and utilising flexible ultra-insulation (vacuum) for pressing titanium (and now aluminium) sheets together. The process operates at low stresses thus avoiding `channel' collapse. Investment is taking place in the partner companies to exploit the technology. A breakthrough has been achieved in the chemical machining of three dimensional structures for laminar flow technology assemblies in aluminium and titanium, that can be built by ADB.
Aston University has developed systems thinking, specifically soft systems thinking, into a new approach known as the Process Orientated Holonic (PrOH) Modelling Methodology which has been used to model, debate and implement changes to strategy and operational processes in service and manufacturing organisations. Through PrOH Modelling our research has changed the awareness, use, and long term legacy effect in a variety of organisations as exemplified here by 4 cases in which considerable operational and financial impacts have accrued. These impacts have been achieved by (i) increasing awareness of systems thinking, particularly soft systems thinking, by management (ii) implementing use of soft systems thinking (as PrOH modelling) to give demonstrable organisational improvement in specific change projects, and (iii) ensuring a legacy effect of systems thinking practice, as managers' use of systems thinking is more effective after an initial Aston University led project has been completed.
The SAFT-VR family of thermodynamic models has made it possible to predict reliably the behaviour of the many complex and challenging fluids that are found across a range of industrial sectors, including oil & gas, chemicals (refrigerants, surfactants, polymers), energy (carbon capture solvents, carbon dioxide-rich streams) and pharmaceuticals.
The SAFT-VR models have had a wide impact on industrial practice. At BP, they have been used to design novel surfactants that have increased the lifetime of oil fields up to five-fold, avoiding maintenance interventions costing millions of dollars and increasing productivity by 50% (worth $2-3 million per year per well). At Borealis, they have been used to understand how to increase the productivity of the reactor in the flagship Borstar process by 30%. At ICI and Ineos/Mexichem, they have been used to design efficient processes for producing replacement refrigerants with much reduced reliance on extreme and expensive experiments involving hydrogen fluoride, a highly corrosive substance. Industrial demand for access to the predictive capabilities of SAFT-VR has been such that Imperial College has licensed the software in 2013 to a UK SME in order to distribute it worldwide to users.
Loughborough University's (LU) interdisciplinary model based systems engineering (MBSE) research (2001-2010) has directly enabled life-saving operations by i) Developing synthetic vision systems to improve the safety of emergency services helicopter operations involving low level flight during day, night, all weather and conditions of zero visibility, and ii) Saving lives through a reduction in morbidity and mortality of babies born with congenital heart defects.
The impact translates directly into significant cost savings and safety risk reductions in expensive flight trials costing millions of pounds by BAE Systems [5.1], and in supporting clinical practice/surgical interventions by University Hospital of Rennes [5.2] with a reduction in the morbidity and mortality of babies born with congenital heart defects in Brittany, France.
Fluid modelling approaches devised by the Materials and Engineering Research Institute's (MERI's) materials and fluid flow modelling group have impacted on industrial partners, research professionals and outreach recipients. This case study focuses on economic impacts arising from improved understanding which this modelling work has given of commercial products and processes. These include: metal particulate decontamination methods developed by the UK small company Fluid Maintenance Solutions; liquid crystal devices (LCDs) manufactured by the UK SME ZBD Displays; and an ink-droplet dispenser module originally invented at the multinational Kodak. Additionally, the modelling group's computer simulation algorithms have been adopted by industrial research professionals and made available via STFC Daresbury's internationally distributed software package DL_MESO. Finally, the group has developed, presented and disseminated simulation-based materials and visualisations at major public understanding of science (PUS) events.