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Cyanobacteria (blue-green algae) occur globally and produce a wide range of potent toxins (cyanotoxins) that can be among the most hazardous natural products in aquatic environments. Research by the University of Dundee uncovered the biochemical mechanism of action of the microcystin family of cyanotoxins, which resulted in the development of new cyanotoxin detection and analytical methods, and demonstrated the health risks of cyanotoxins. This body of research has had a direct impact on several governmental and regulatory authority guidelines on water safety, resulting in the implementation of procedures to reduce the risks presented by cyanotoxins to water-users.
Our impact has been to protect the public by informing and influencing both the international policy debate on health claims associated with soy consumption, and the relevant regulatory risk assessment authorities.
Our research formed a key component of dossiers that resulted in the rejection of health claims by the European Food Safety Authority (EFSA, the EU agency responsible for the scientific substantiation of health claims) relating to soy isoflavones and a number of health endpoints including bone health, heart health and menopausal symptoms. Earlier work had underpinned decisions on comparable health claims in the US and UK.
Our soy isoflavone research also provided key scientific data on the absorption of isoflavones by the body (and dependence on age and food source) to the UK Government Committee on Toxicity (COT) policy review on the toxicity of chemicals with a specific focus on soy infant formula. This expands on COT advice in 2003, which used earlier Cassidy research and helped to inform the UK government's (Food Standards Agency) research programme on phytoestrogens /isoflavones.
Strathclyde research underpinned formation of the Scottish Chikhwawa Health Initiative (SCHI) in 2006, to deliver tangible health benefits by reducing major causes of disease and death in Chikhwawa, Malawi. Health impact occurred through training of government personnel and community volunteers, combined with increased infrastructure capacity, at health facilities and in the community, producing improvements in water quality, sanitation and communicable disease control. Within the first 2 years of implementation among a population of 5700 people, a 30% reduction in diarrhoeal disease was achieved, and access to safe water improved through increased water points and improved water storage [1]. Initial success saw expansion of the initiative to 150 communities covering a population of 110,000.
The impact of research by the University of Southampton into global access to safe drinking water has: (i) provided important evidence for new policy initiatives by the World Health Organisation and UNICEF to promote home water treatment to reduce the 1.9 million deaths each year due to water- related infections, and (ii) stimulated debate among a range of stakeholders, including the media, advocacy groups and UN bodies, by challenging the accuracy of the assertion by the UN Secretary General that the UN Millennium Development Goal for safe water access has been met.
New health-evidence-based water quality criteria affecting over 24,000 EU bathing waters were implemented throughout the EU in 2012. These quantitative standards for microbial concentrations in sea water were based on WHO guidelines that were developed by Aberystwyth University's Centre for Research into Environment and Health (CREH) and founded on CREH's world-leading research. These standards (i) shape public policy by providing more rigorously-defined, quantitative health-based criteria, and (ii) improve implementation of environmental policy by facilitating the incorporation of real-time prediction of water quality, designed to provide `informed-choice' to bathers. Application of the standards on their own, i.e., without the prediction element, will result in the loss of 50% of UK's `Blue Flag' beach awards. With CREH's predictive element, however, the UK will both keep its blue flags and have higher standards of health protection. This prediction element is estimated by Defra to be worth between £1.4 and £5.3 billion to the UK economy over a period of 25 years following its initial implementation in 2012.
The Galatean Risk and Safety Tool (GRiST) is a clinical decision support system (CDSS) conceived and developed by computer scientists at Aston University from 2000 onwards, where it is being delivered as a cloud-computing service. It is used every day by mental-health practitioners in the NHS, charities, and private hospitals to assess and manage risks associated with mental-health problems. Between 1/1/2011 and 31/7/2013, clinicians provided 285,426 completed patient risk assessments using GRiST. It has changed organisational and clinical processes by its systematic collection of risk information, explicitly linking data to clinical risk judgements, and showing how those judgments are derived. Increasing international awareness has come through presentations to mental-health practitioners in Europe, America, and Australia.
This study analysed the shallow well drinking water quality of 17,000 rural Malawians. Water officials were advised interim precautions to take regarding grossly contaminated wells. Inter alia, the `Water Resources Investment Strategy', World Bank funded, captured this data to help develop policy. A new MSc course was established to educate water officials. Workshops/Fieldtrips integrated this research into the undergraduate curriculum. An indigenous sustainable natural water purification system was developed to reduce contaminates at source. Initial data indicates that water quality can be improved by up to 80%. This has the potential to improve the water quality for 1.5 million Malawians.
Diarrhoeal disease is the world's second most common cause of death in children under five years old, killing 760,000 children each year according to the World Health Organisation (WHO). Microbial contamination of drinking water is one of the most important causes. In England and Wales acute diarrhoeal disease is estimated to cost the country £1.5 billion annually. UEA epidemiologists have shown the important role of water supply systems in spreading diarrhoeal disease in developed and developing countries; led WHO research projects on small scale drinking water systems; and influenced WHO policy on small scale drinking water systems in developed and developing countries. Methodological research on epidemiological methods for monitoring and regulating bathing water quality has led to changes in WHO guidance on bathing water quality standards and influenced US Environmental Protection Agency criteria. Hunter's participation in international expert panels facilitated the impact of this research on policy.
New characterisation tools for natural organic matter (NOM) in drinking water are now used as standard practice within water companies such as Severn Trent Water, United Utilities and Yorkshire Water. The tools inform decisions, and help develop strategic plans on catchment management, source selection, treatment optimisation, and disinfection practice. Water companies experienced difficulties in treating high levels of NOM. Cranfield created a novel characterisation toolkit to measure NOM for its electrical charge and hydrophobicity. Also, new techniques for measuring aggregate properties and emerging disinfection by-products have provided a comprehensive analysis. Two novel treatment technologies are currently marketed. These technologies have raised international interest, resulting in industrial development in Australia.
Health inequalities are recognised as a critical UK policy issue with life expectancy gaps of up to 28 years between the least and most deprived areas. This case-study demonstrates how Durham University research has led to: (a) changing health service commissioning (with County Durham and Darlington Primary Care Trust [PCT]): (b) influencing NHS funding policy (by generating Parliamentary debate); as well as (c) contributing to the development of the new public health system in England and Wales (as part of the Strategic Review of Health Inequalities in England post-2010 [Marmot Review]).