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In 2007, as part of a major update of the national alcohol strategy, the UK Government announced that it would commission an independent national review of the evidence on the relationship between alcohol price, promotion and harm. Subsequently, in 2008, researchers from the University of Sheffield (UoS) were commissioned by the UK Department of Health (DoH) for an `Independent Review of the Effects of Alcohol Pricing and Promotion'.
The UoS research has played a crucial role in informing the debate and deliberations on the available Government options for interventions on alcohol consumption in England and Wales, by providing a robust evidence base to underpin the debate. The UoS research findings have been used to inform policy by senior decision-making bodies e.g. the House of Commons Health Select Committee and the UK Chief Medical Officer to inform policy. The findings have also stimulated the potential for policy intervention beyond England and Wales, e.g. in Scotland and Australia.
As a result of University of Sheffield research in 1995-2002, a new gold standard treatment for major bleeding on warfarin has been established, ensuring the more effective treatment of tens of thousands of patients requiring emergency anticoagulation reversal each year in the UK alone. The treatment, using prothrombin complex concentrate (PCC) was demonstrated to be superior to fresh frozen plasma (FFP), the standard alternative at the time, and two PCCs have now been licensed for this indication in the UK.
UK and international guidelines now recommend PCC over FFP.
Our research `In the City' has uncovered new histories of post-medieval and modern Sheffield. We have worked with local charities, heritage groups, arts organisations and Sheffield City Council, to transform the historic environment, to make places safer and more accessible for people to enjoy and value, and have used our research to benefit economically and socially deprived communities and particularly young people. Our initiatives have delivered cultural, social, educational, economic and environmental impacts for the people of Sheffield.
The Arctic is undergoing faster rates of climate change than most other regions of the world, with major global consequences. Since the 1990s, Professor Callaghan and co-workers at Sheffield have been at the forefront of determining climate change impacts on Arctic ecosystems. This research has directly led to, and fed into, invited authorship and major co-ordination roles in the authoritative international synthesis reports on climate change impacts commissioned by the Arctic Council and the Intergovernmental Panel on Climate Change (IPCC). Through these reports our findings have been widely communicated to international policymakers, the media and society. Callaghan and colleagues have provided policy advice directly to ministers, ambassadors, climate negotiators, and other leaders through face-to-face meetings and presentations, and influenced policy debates at regional to international levels. They have actively engaged in knowledge- exchange activities with Arctic indigenous societies, which are improving those societies' strategies for adaptation to climate change. Through public lectures, the media and authorship of a commissioned textbook, the Sheffield research findings have increased public understanding and influenced the A-level Geography curriculum.
One of the world-leading systems for large-vocabulary Automatic Speech Recognition (ASR) has been developed by a team led from the University of Sheffield. This system, which won the international evaluation campaigns for rich speech transcription organised by the US National Institute for Standards and Technology (NIST) in 2007 and 2009, has led directly to the creation of one spin-out, been largely instrumental in the launch of a second, has had significant impact on the development and growth of three existing companies, and has made highly advanced technology available free for the first time to a broad range of individual and organisational users, with applications including language learning, speech-to-speech translation and access to education for those with reading and writing difficulties.
Research investigating genetic and environmental interactions leading to skin barrier breakdown in atopic eczema has delivered health benefits by improving the prevention and treatment of this condition. We found that established emollient formulations (e.g. Aqueous Cream BP) containing the harsh emulsifier sodium lauryl sulphate (SLS) damage the skin barrier in patients with atopic eczema and identified an underlying molecular mechanism. Consequently, the NICE Quality Standard and Guidelines now reflect our advice that Aqueous Cream should not be used as a leave-on emollient, SLS has been removed from all emollient formulations in the UK and we have helped develop the next generation of `SLS-free' skin-care products. Medicines regulators including the Medicines and Healthcare products Regulatory Agency (MHRA) and New Zealand MedSafe have also issued new advice as a result of our research.
The BUGS research project (1999-2007) at Sheffield was the first large-scale study to reveal the importance of domestic gardens for urban biodiversity. The evidence gathered showed, for the first time, that the extent of gardens, their unique features, and the biodiversity they support makes them a nationally important ecological resource, contributing enormously to conservation and human-nature interactions in urban environments. The results were reported in a series of 13 ISI-listed papers, a popular book and two articles in British Wildlife. The research has had impacts across many audiences and applications ranging from evidence for planning policy changes, through the science to support advisory and campaign groups, to informing public awareness of the merits of individual garden management practices. BUGS research has been a key catalyst in the increased recognition of the importance of gardens in supporting urban biodiversity.
A €470 million earth observation mission (BIOMASS) based on research carried out in the University of Sheffield's Centre for Terrestrial Carbon Dynamics was approved by the European Space Agency Programme Board on 7 May 2013, for launch in 2020, to measure the biomass and height of the Earth's forests, globally, at a scale of ~200 m. The twenty European member states have committed contributions to fund the mission, representing a significant reallocation of public budgets. The mission was selected as the most scientifically convincing of the six initially shortlisted in 2005 (further down-selected to three in 2009), and is the only one that will be funded. The project has already led to two European industrial consortia receiving some €5.6 million for studies to demonstrate feasibility. A further €277 million of the €470 million approved funding has been specifically earmarked for industrial spending to prepare for the mission.
Our research has led to the development of guidelines on the diagnosis of deep vein thrombosis (DVT), reducing the risk of death and saving resources by reducing unnecessary tests and treatments.
Meta-analysis and decision-analysis modelling studies undertaken at the University of Sheffield between 2005 and 2007 formed the basis of the National Institute for Health and Clinical Excellence (NICE) and the American College of Chest Physicians (ACCP) guidelines for diagnosing DVT. These guidelines determine the management of over 140,000 patients each year in the United Kingdom with suspected DVT, and many more in other countries.
Falls are a common and serious health risk for older people and reducing falls is a priority for the NHS. Research at the University of Bradford on the link between vision and falls has led to new healthcare guidelines, specifically those from the College of Optometrists and the British Geriatrics Society and endorsed by Age UK and the Royal College of General Practitioners. Continuing professional development practices have changed and public awareness of this health risk has been raised by Which? reports and subsequent media coverage. These developments have impacted on the health and welfare of older people, particularly those at risk of falls.