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Dr Lister's pioneering research into people's perceptions of safety in relation to anti-terrorism measures has significantly shaped and informed public and political debate in this complex and controversial area. Lister has co-authored submissions to the Home Office, provided a policy briefing to the National Assembly for Wales, hosted a workshop with representatives from `think tanks' and government departments. Additionally, he has engaged with a variety of civil society/advocacy groups and published commentary (including by invitation) on this area of public policy. Lister has highlighted the negative experiences of a range of ethnic minority citizens, as well as demonstrating the merits of using evidence based research in a highly political and sensitive arena.
Responding to the crisis in confidence amongst clinicians involved in child protection, Cardiff University developed the world's first research programme to provide the scientific basis for more reliable clinical assessments of child abuse and neglect. The programme, which involves 21 systematic reviews (updated annually) and related primary studies, has directly informed five national clinical guidelines, the National Child Protection training program and the first NICE guidance on child maltreatment. Through the Core-Info website, the evidence base created by the Cardiff team is accessed each year by 100,000 users. Key messages from their research have been published in a series of Core-Info leaflets which have reached more than 250,000 allied professionals nationally. The Cardiff research informs standardised national clinical practice, training and legal decisions, ultimately improving the recognition and protection of children from abuse or neglect.
This case study details the impact of research on the biomechanics of ageing, and the translation of novel methods developed in this research into clinical applications for Parkinson's disease. Our work, commissioned by and developed with English National Ballet (ENB), has raised the profile of dance as a novel health intervention, promoting the health of patients and facilitating the public services of ENB. The reach of our impact is international, and includes a wide range of beneficiaries including Parkinson's patients, dance and health professionals, the general public, ENB and other dance organisations. The significance of our work is indicated by the profound differences it has made to the beneficiaries, awards that the project has received, and the substantial press coverage it has attracted.
Ongoing research by the University of Southampton has led to significant advances in the understanding of respiratory diseases, for which the dearth of available treatments had health repercussions on a global scale for many years. The formation of a spin-out company, Synairgen, has enabled the discovery and development of new therapeutics, the filing of several major patents in the UK, the US and Asia and external collaborations with industry and government funders. These continuing developments are key to tackling conditions that affect millions of sufferers in the UK alone and which, according to some estimates, cost the NHS £2.6bn every year. The research has given rise to more than £16m in follow-on funding from the NIHR and the MRC for further studies into the treatment of respiratory illnesses.
During the conflict, community relations work had low strategic importance. Morrow et al (1997) demonstrated that the absence of an overarching conceptual framework stifled government policy and so subsequently developed a ground breaking model of community relations engagement to be mainstreamed into government policy (around equity, diversity and interdependence). Following two major government reviews of community relations in 2002 and 2003-5, these research findings were adopted as central to public policy and resource allocation, and reconfigured as `A Shared Future'.
Since 2008, the core concepts of Morrow et al's work have been explicitly integrated into the vision and values of many policies and practices around reconciliation, community relations and a shared future demonstrating a continuing, cascading impact at local, regional, national, European and international levels.
Cardiff University research led to second-generation chemiluminescent technology. The invention allowed for internal amplification control in nucleic-acid based clinical diagnostic assays for infectious disease and produced results with greater accuracy and fulfilled previously unmet regulatory standards. Adopted by the market leader in nucleic acid diagnostics (a sub-licensee of Cardiff University) the Cardiff technology is used globally in more than 60 million in vitro diagnostic tests annually. Sales of the tests approach $500 million per year and the sub-licensee was subsequently sold for $3.8 billion.
Research at Cardiff University is underpinning the abandonment of the 100-year-old surgical practice of removing all axillary lymph nodes in cases of breast cancer. Such surgery frequently caused arm lymphoedema, loss of arm mobility and lymphatic system damage. Cardiff led the seminal ALMANAC trial which showed that full node clearance was unnecessary if a biopsy of the first draining `sentinel' node was cancer-free. Cardiff then spearheaded the impact on practice through a training and awareness programme for surgeons, primarily in the UK, but also in China, India, Brazil and Turkey. By 2010 these efforts had established the Sentinel Lymph Node Biopsy (SLNB) procedure as standard in the UK, while the study was also cited in USA guidelines. The main beneficiaries of the impact are the 50-75% of breast cancer patients who now enjoy lower levels of pain, shoulder disability and arm lymphoedema. Healthcare providers also benefit financially from a reduced need for extensive surgery.
Mytum's research excavation and extensive reconstructions at the Iron Age archaeological site at Castell Henllys benefitted Pembrokeshire Coast National Park through integration of the research results into their visitor resources, educational programmes and management plans, developed with the Castell Henllys project's guidance. In particular, because the `Celts' are a key part of the Welsh National Curriculum at Key Stage 2, Castell Henllys features both on the National Park website provision and as an important element of their schools visit programme. This previously unvisited site has become a major educational centre and significant local tourist attraction only because of the project's long-term excavations and reconstruction.
Research at UCL on human haemolytic anaemias known as the `hereditary stomatocytoses' has improved diagnosis of these conditions, meaning that patients now avoid unnecessary and potentially life-threatening splenectomies, and inappropriate investigation and treatment for raised potassium levels. Identification of a common single nucleotide polymorphism that causes apparently normal red blood cells to leak salt when cooled (as is normal procedure with donated blood) has raised awareness of this issue in the NHS Blood and Transfusion service, with the result that individuals with this condition have been identified among existing donors, and work is underway to develop a screening method to exclude such individuals from donating blood that cannot be stored safely. Finally, the research has facilitated diagnosis of the recessive metabolic disorder phytosterolaemia by blood count, allowing these individuals to be given appropriate dietary treatment to control their cholesterol levels.
We demonstrate a sustained record of the highest quality public engagement with physics, evidenced by the selection of our research for the Royal Society Summer Science Exhibition on eight occasions in six successive years (2008 - 2013). Collectively, these exhibits have received more than 94,000 visitors, increasing the knowledge of physics and interest in physics of school pupils and the general public. Each exhibit has produced a lasting legacy of on-going public engagement, influencing, for example, the career choices of an estimated 60,000 students.