Rapid Antibiotic Treatment Reduces the Prevalence of Lameness caused by Footrot in Sheep
Submitting InstitutionUniversity of Warwick
Unit of AssessmentAgriculture, Veterinary and Food Science
Summary Impact TypeEnvironmental
Research Subject Area(s)
Agricultural and Veterinary Sciences: Veterinary Sciences
Medical and Health Sciences: Clinical Sciences
Summary of the impact
Footrot (FR) causes 90% of lameness in sheep. FR reduces productivity and
lowers sheep welfare. Research at the University of Warwick, initiated in
1999 and still active, has led to the development of a novel management
strategy for footrot in sheep: prompt antibiotic treatment (PAT) - sheep
treated with intramuscular and topical antibiotics within three days of
becoming lame with FR. This has resulted in a reduction in the overall
prevalence of lameness in sheep flocks in England from 10% (2004) to 5%
(2011) and 3% (2013). In 2011, evidence from research at Warwick on PAT
was used by the Farm Animal Welfare Council of Great Britain to support
their statement that it was feasible to reduce the prevalence of lameness
in the national flock from 10% to 2% by 2021. From 2005 onwards, PAT has
been disseminated to 50,000 sheep farmers through knowledge transfer (KT)
by EBLEX, the levy body for sheep farmers in England using booklets, CDs
and more than 100 on-farm events. More than 50% of farmers who had
attended an EBLEX KT meeting on lameness stated that they had changed
their management of lameness as a result of new information from the
event. The Sheep Veterinary Society in the UK has adopted PAT as the
recognised management approach for FR and a leading sheep vet in Germany
has written a book promoting PAT. The work has been presented in Europe as
part of Animal Welfare Research in an Enlarged Europe (AWARE), an
EU-funded project educating all countries in the enlarged EU zone on
animal welfare (http://tinyurl.com/o6onaxd).
In 2012, the lead Warwick researcher Professor Green was awarded the Royal
Agricultural Society of England medal specifically for `impact to the
sheep farming community in reducing footrot in sheep'.
Footrot (FR) is listed in the top five most important diseases of sheep
in all countries with large sheep industries. Leaving sheep lame reduces
body condition, increases the risk of death, infertility or small litter
size and reduces lamb growth rates1. Research from Professor
Green's team at the University of Warwick's School of Life Sciences has
shown that interdigital dermatitis (ID) is a mild presentation of FR,
caused by the same bacterium, Dichelobacter nodosus (Calvo-Bado et
al., 2010; Witcomb, 2012).
Footrot (henceforward including ID) causes 90% of lameness in sheep in
England2 and reduces productivity and welfare1. The
cost to the GB sheep industry is estimated at £24 - £801
million per year. In 1999, Warwick researchers, together with
collaborators at Bristol University, proposed that either the current
recommended methods to control lameness were ineffective or that farmers
were unable to implement them effectively. Management of FR at that time
centred on regular whole- flock managements of foot trimming and
footbathing. Individual lame sheep were primarily treated by trimming hoof
horn to reveal foot lesions, and spraying feet with topical disinfectant.
There was no evidence that this approach was effective and the 1999 study
indicated that farmers who were managing FR effectively were treating all
individual sheep lame with FR3 using antibiotic by injection
and topical application. The flock managements described above were
ineffective. In a Warwick-led 18-month within-farm clinical trial of 800
ewes (2005 to 2006)1 the mean prevalence of lameness in 400
ewes that were treated by foot trimming and foot spraying when lame with
FR was 7% over 18 months whilst the prevalence of lameness in 400 ewes
treated by PAT when lame with footrot fell to 2% after 6 - 12 weeks and
remained at this level3. A Warwick- only clinical trial (2008)4
was used to compare PAT and prompt foot trimming with topical disinfectant
on time to recovery in a factorial design with 53 ten-month-old ewes.
Results were that PAT of sheep lame with FR led to recovery from lameness
and active foot lesions in one to ten days in over 95% of sheeep4
whilst less than 25% of sheep treated with the traditional method of foot
trimming and topical disinfectant recovered in ten days4.
Further analysis of the 2005 - 2006 data indicated that PAT prevented
development of poor foot conformation and led to recovery from existing
poor foot conformation; it also prevented recurrent lameness5.
In another Warwick-only study (2005)6 it was shown that whilst
farmers could identify lame sheep accurately (giving confidence to farmer
estimates of prevalence of lameness in their flock1,3 ) they
did not treat all lame sheep but made a separate decision on whether to
catch and treat lame sheep6,7. Consequently, some lame sheep
are left untreated, rather than being treated promptly. Farmers that
delayed treatment of lame sheep reported a higher prevalence of lameness
in their flock than those who treated lame sheep promptly6.
conclusion, approximately 80% of the 10% prevalence of lameness in sheep
can be explained by delay in treatment of sheep with FR, together with
using the sub-optimal treatment of foot trimming and foot spraying. If all
farmers adopted PAT the prevalence of lameness in the GB flock would be
expected to fall from 10% to 2%, with much of the 2% prevalence of
lameness being sheep recovering from FR or lameness caused by conditions
other than FR. From the 2005 to 2006 study, in a flock with an average
prevalence of 7% lameness, the net loss of failing to use PAT was £6 to
£10 per ewe in 20061.
Some of this research was carried out in conjunction with the University
of Bristol: Warwick led all the research. All KT with EBLEX (talks,
development of educational material) was undertaken by Green, Kaler,
Wassink and King.
PI: Professor Laura Green, School of Life Sciences (1999-present).
Professor Green is an internationally renowned infectious disease
epidemiologist whose motivation is to improve the health and welfare of
Co-Is: Professor Graham Medley (1995-present); Professor Elizabeth
Wellington (1987-present), School of Life Sciences.
Postdoctoral research assistants:
Dr Leo Calvo Bado (2007-2011); funded by BBSRC CEDFAS (Combating Endemic
Diseases of Farm AnimalS) project, Dr Jasmeet Kaler (2007-2010); funded by
BBSRC CEDFAS. Now a Lecturer in Epidemiology at the University of
Nottingham. Dr Geert Wassink (1999-2009); funded by MAFF and Defra
Ph.D. students: Luci Witcomb (2008-2012); Elisabeth King (2009-2013)
funded by NERC and BBSRC CASE awards.
Co-I: Dr Lynda Moore (1999-2006) and Dr Rose Grogono-Thomas
(1999-present), Lecturer and Senior Lecturer, respectively, University of
Bristol School of Veterinary Science.
References to the research
(identified in statement by superscript number)
1. Wassink, G.J., King, E.M., Grogono-Thomas, R., Brown, J.C., Moore,
L.J. and Green, L.E. (2010) A within farm clinical trial to compare two
treatments (parenteral antibacterials and hoof trimming) for sheep lame
with footrot. Preventive Veterinary Medicine, 96, 93 - 103 (0167- 5877) DOI:10.1016/j.prevetmed.2010.05.006 [Ref2]
2. Kaler, J. & Green, L.E. (2008) Naming and recognition of six foot
lesions of sheep using written and pictorial information: a study of 809
English sheep farmers. Preventive Veterinary Medicine, 83 (1), 52 - 64
3. Wassink G.J., Grogono-Thomas R., Moore L.J. & Green L.E. (2003)
Risk factors associated with the prevalence of footrot in sheep from 1999
to 2000. Veterinary Record, 152, 351 - 358 (0042-4900). DOI:
4. Kaler, J., Daniels, S.L.S., Wright, J.L. & Green, L.E. (2010) A
randomised factorial design clinical trial to investigate the impact of
parenteral long acting oxytetracycline, foot trimming and flunixine
meglumine on time to recovery from lameness and foot lesions in sheep lame
with footrot', Journal of Veterinary Internal Medicine, 24, 420 - 425
5. Kaler, J., Medley, G.F., Grogono-Thomas, R., Wellington, E.M.H.,
Calvo-Bado, L.A., Wassink, G.J., King, E.M., Moore, L. J., Russell C.,
& Green L.E. (2010) Factors associated with changes of state of foot
conformation and lameness in a flock of sheep. Preventive Veterinary
Medicine, 97, 237 - 244 (0167-5877). DOI:10.1016/j.prevetmed.2010.09.019
6. Kaler, J., George, T.R.N. & Green, L.E. (2011) Why are sheep lame?
Temporal associations between severity of foot lesions and severity of
lameness in 60 sheep. Animal Welfare, 20, 433 - 438 (0962-7286).
7. King E.M. & Green, L.E. (2011) Assessment of farmer recognition
and reporting of lameness in adults in 35 lowland sheep flocks in England.
Animal Welfare, 20, 321 - 328 (0962-7286).
Key peer-reviewed grants/awards
8. Ph.D. thesis - King, 2013: Lameness in English lowland sheep flocks:
farmers' perspectives and behaviour (http://tinyurl.com/o6v3rtc).
- MAFF, "Investigations into the microbiological causes and effective
control of footrot" (Grant reference AW1007) PI Green; Amount awarded
£198,321 (1999-2003). Grant final report:
- DEFRA, "Intervention study to minimise lameness in sheep" (Grant
reference AW1021), PI Green; Amount awarded £340,735 (2005-2007). Grant
- EBLEX, "Technology transfer to the sheep industry": PI Green: £100K
- BBSRC CEDFAS, "A molecular epidemiology approach to combating footrot,
an important endemic disease of sheep" (Grant reference BB/E01870X/1),
PI Green; Amount awarded £901,721 (2007-2012). Grant final report:
- BBSRC, ISIS travel award to Australia for J. Kaler and L.E. Green,
linked to BB/E01870X/1, PI Green; Amount awarded £4,000 (2008).
- BBSRC, Partnering India Award, linked to BB/E01870X/1, PI Green;
Amount awarded £16,888 (Grant reference BB/G530292/1) (2009 - 2011).
Grant final report: http://tinyurl.com/onex28t.
- BBSRC, Industry interchange programme with Eblex, linked to
BB/E01870X/1, PI Green; Amount awarded £50,000 (2010-2011).
- Defra, "Motivating change in sheep farmers: the example of footrot";
PI Green; (Grant reference AW0512) Amount awarded £519,106 (2011-2014).
Ph.D.s resulting from the research
Jasmeet Kaler (2004-2008) MLC, competitively awarded, supervisor Green:
Luci Witcomb (2008- 2012) NERC CASE Pfizer, supervisors Wellington and
Green: Vinca Russell (2008-2012) BBSRC Pfizer CASE (linked with Roslin),
supervisors Green, Medley and Bishop: Elisabeth King (2009- 2013) Pfizer
BBSRC industrial CASE, supervisor Green: Mohd Muzafar (2011-2014) Warwick
Chancellors Overseas Scholarship, competitively awarded, supervisors
Wellington and Green
Details of the impact
Animal health and welfare: In 2004, the mean flock prevalence of
lameness in England was 10.4% (9.2-11.0% - 95% standard error intervals)
and 10% of farmers were always using PAT (prompt antibiotic treatment) to
treat sheep lame with FR (including ID), according to 809 farmers randomly
sampled from the EBLEX database2. By 2011, the median flock
prevalence of lameness in England was 5% (interquartile range 2-10%) and
25% of farmers were using PAT, according to 445 farmers randomly sampled
from EBLEX8. Most recently, results from 1,200 farmers randomly
selected from all English sheep farmers gave a median estimated lameness
in 2012 of 3% (unpublished data, Green et al., available upon
Adoption of practice in the GB sheep industry: In 2010, Professor
Green was asked to present evidence on managing lameness in sheep to the
UK Farm Animal Welfare Council (FAWC). Their "Opinion on Lameness in
Sheep" was published in 2011 with the recommendation that the prevalence
of lameness should be reduced from the current 10% to 5% by 2016 and to 2%
by 2021 using existing knowledge from our research (source A). The Opinion
is accessed at a rate of about 300 downloads per month (information can be
corroborated by email). Several retailers and quality assurance schemes
that are strongly influenced by the FAWC are now monitoring lameness and
provide advice to farmers on the appropriate treatment of lame sheep based
on the evidence from our research1-8.
Veterinary practitioners and consultants - Nationally and
Internationally: The results from this research have been presented
at Sheep Veterinary Society (SVS) meetings and published in SVS
proceedings. They have also been published in veterinary professional
journals such as UK Vet (Source B), where leading practitioners discuss
novel approaches to management, treatment and engaging with farmers and
also presented at other professional conferences, raising vets' awareness
of our findings.
The Warwick research has created a sea change in understanding how to
control FR both in the UK and internationally (sources A-H). At a Sheep
Veterinary Society meeting (September 2011) we presented our evidence that
ID and FR are the same disease, a concept that was not accepted by many in
the UK's veterinary and farming community. As a result of this, the Sheep
Veterinary Society drafted new national recommendations on the treatment
and control of FR in sheep that are due to be published (source C).
Multiple hundreds of specialist sheep vets have been using PAT since 2006
and have seen the benefits for their clients (sources D and E).
international level, the major impact has been an increasing acceptance
and understanding that management of FR has to vary by country and is
dependent on prevalence of the disease and local climate. In the past,
adoption of Australian managements in GB has been a major stumbling block
and disenfranchised farmers who became frustrated that the managements
they used were ineffective. Warwick's research has been taken up in
Germany, where it has been used extensively by their national sheep
veterinary society in their national flock health improvement programme
and published in a book specifically written about footrot in sheep
(source F). National recognition is evidenced: Professor Green was awarded
the Royal Agricultural Society for England Research Medal in 2012 for
"outstanding scientific work in reducing the impact of footrot in sheep".
Farmers: Professor Green has explained PAT, with supporting
evidence, at over 50 farmer meetings since 2005 with audiences of 20 to
200 sheep farmers. She has many individual emails from farmers reporting
in their success. An example of farmer success is a letter from a Welsh
sheep farmer and member of FAWC (source G). In 2006, Professor Green and
her team worked with EBLEX to produce a Better Returns manual on
"Minimising Lameness" (distributed to 50,000 producers) and CD (5,000
copies including a library of condition images to help with lesion
identification and further details; video footage from this has been on
YouTube since January 2012 at http://tinyurl.com/ncymc3r)
(source H). Updates and further information were sent to 30,000 producers
as a paper bulletin. In a survey of participants carried out for EBLEX by
independent survey specialists Noesis in 2010, 57% of sheep farmers
surveyed claimed to have adopted at least one of the methods from the
research on sheep health (source I). Similar information has been produced
by farmers in Wales by HCC and Farming Connect, both by Green and Welsh
Vets. Green has spoken at and attended agricultural shows such as The
Royal Show, Sheep 2006, Sheep 2008 and Sheep 2010 to promote the new
approach to managing footrot to farmers. As a result of the 2009 BBSRC
Industrial Partnership, Green initiated "train the trainer" events with
EBLEX in 2010, these are professional development days geared towards vets
that educate them on lameness and other important issues that sheep
farmers want their vet to understand e.g. nutrition and genetics with the
aim of reaching out to their clients.
Other approaches to impact
In addition to the dissemination activities mentioned above, the Warwick
team has developed and maintains a website on footrot for farmers and vets
with a very high hit rate, over 2000 individual visitors per 6 months (http://www.footrotinsheep.org)
(source J). Articles were published in veterinary and industry journals
(UK Vet, RCVS website, Journal of RASE, 2012). The findings have also been
publicised through articles in national and local papers - The Daily
Telegraph (16 October 2008), Western Daily Press (25 October 2008) and
Western Morning News (22 October 2008) - and in the farming press -
Farmers Guardian (14 November 2008), Farmers Weekly (2011) and The Sheep
Farmer (2008). Professor Green participated in a webinar hosted by
Farmer's Weekly in 2012. The Warwick work has been widely reported
internationally (Canada 2011, USA 2011, Ireland 2012).
Sources to corroborate the impact
(identified in Section 4 as sources A - K)
A. FAWC "Opinion on Lameness in Sheep", March 2011 (http://tinyurl.com/n9me38l).
Professor Green and the team's input are acknowledged and referenced seven
B. Green et al. Clinical Forum: "Understanding lameness in
sheep: Managements for today", UK Vet: Livestock 16(5), 30-42
C. Sheep Veterinary Society, "Advice on best practice for treating and
controlling footrot", written 2012 (available from SVS and Warwick).
D. Letter of support: Independent Veterinary Consultant and Farm Skills
(LANTRA-accredited) Trainer, Cumbria, UK. (Identifier 1).
E. Letter of support: Practicing Vet, Torch Farm & Equine Limited,
Devon, UK. (Identifier 2).
F. Letter of support: Practicing Vet and overseas member of British Sheep
Veterinary Society, Deutsche Veterinärmedizinische Gesellschaft e.V.,
Germany (Identifier 3).
G. Letter of support: Welsh Sheep Farmer and Chair
FAWC Ruminant Working Group Identifier 4).
H. EBLEX Sheep Better Returns Programme Manual 7. "Target Lameness for
Better Returns", 50,000 pamphlets/5,000 CDs created; content by Professor
Green provided in 2008; reprinted in July 2013. Also on YouTube at
I. Letter of support: EBLEX, Head of Knowledge Transfer. (Identifier 5).
J. Footrot in sheep website: www.footrotinsheep.org.
From October 2012 to March 2013 there were 2,256 unique visitors.