Improved animal health and welfare and economic benefits for farmers from better management of parasites in livestock
Submitting InstitutionUniversity of Bristol
Unit of AssessmentBiological Sciences
Summary Impact TypeEnvironmental
Research Subject Area(s)
Agricultural and Veterinary Sciences: Animal Production, Veterinary Sciences
Medical and Health Sciences: Public Health and Health Services
Summary of the impact
Research conducted at the University of Bristol between 2003 and 2012 on
the ecology, epidemiology and control of parasitic flies and worms has
improved animal health and welfare in the UK and is addressing a major
constraint on global food production — animal disease, particularly in the
context of climate change. These are some of the impacts:
- In 2011, industry benefited from research on blowfly strike which has
provided scientific evidence that strategic early treatment of sheep
reduces season-long disease risk and results in financial savings for
farmers, particularly where earlier emergence of flies occurs in
response to warming temperatures.
- Between 2008 and 2012, farmers realised a 73% direct saving in the
monitoring of gastrointestinal nematodes due to the development of a
composite faecal worm egg count (FEC) test and a decrease of up to 75%
in the number of treatments given to lambs.
- Farmers and livestock benefited from the slower development of
anthelmintic-resistant parasites as a result of targeted treatment using
the composite FEC test developed.
Research at the University of Bristol, led by Professor Richard Wall and
Dr Eric Morgan, focuses on the ecology, epidemiology and control of
parasitic flies and worms. Wall has worked at UoB since 1985 and was
appointed to a personal chair in 2000; Morgan was appointed as a
university lecturer in 2002 and promoted to senior lecturer in 2010. Their
work has ranged widely over studies of the epidemiology of disease, risk
factor analysis, spatial disease modelling, morphological and molecular
characterisation of parasite populations and the development of targeted
and environmentally sensitive control approaches. This research has been
carried out entirely at the University of Bristol with the assistance of
PDRAs (J.R. Stevens, I. Cruickshank), PhD (K.E. Smith, A. Fenton, J.
Broughan, B. Bisdorff, H. Rose, L. Ellse & J. Van Dijk) and MSc (M.
Walters) students, who have been named as co-authors on the research
papers published. Where agencies such as the Animal Health and Veterinary
Laboratory Agency (AHVLA) have provided data, key agency staff have also
been included as co-authors on the publications.
Blowfly strike: Blowfly strike is the infestation of living hosts
by fly larvae. It is a particularly important disease of sheep in the UK,
where over 80% of farms may be affected each year and more than half a
million animals infested (source A). Professor Wall's ongoing research has
contributed significantly to current knowledge in a wide variety of areas,
particularly blowfly epidemiology and ecology and, recently, the probable
impact of climate change. Between 2003 and 2004, Wall and his colleagues
investigated regional variation in the prevalence of blowfly strike in
Great Britain as part of a broad survey of disease on British farms. The
research was specifically looking for changes in disease prevalence that
might have occurred since the withdrawal of compulsory dipping legislation
in 1989/92 . They found that blowfly strike remained a widespread
problem, with the highest prevalence in the south west of England, and
that there had been little change since 1989/92. This evidence confirmed
the national severity and prevalence of the condition, highlighting the
need for improved disease management. Building on this baseline, Wall's
work subsequently used modelling studies to evaluate likely spatial and
temporal changes in the prevalence of blowfly strike that might be
expected in response to predicted climate change in Great Britain . His
findings have shown that under predicted warming scenarios, there is
likely to be an increase in the risk of strike, an earlier spring
emergence of blowflies and an elongated blowfly season [2, 3]. Wall's
research also used stochastic models to examine the likely effects of
changes in husbandry and control strategies. These studies demonstrated
that appropriate timing of control is critical and that a change in
shearing date, from early June to early April, can also significantly
reduce risk of strike . The model predictions were tested in farm-based
studies, which confirmed that the early-season treatment of ewes with
insecticides can reduce season-long strike incidence through its effects
on fly population dynamics . It is this recent research, illustrating
the need for early-season treatment of sheep, which has been taken up by
industry and incorporated into the advice that Novartis Animal Health
provides to farmers regarding the use of their products. Economic
modelling by Wall has suggested that appropriate strategic treatment may
result in savings of about £200 per farm per year which, in the current
economic context of sheep husbandry, is an appreciable benefit.
Gastrointestinal nematode infection: Gastrointestinal nematode
(GIN) infection is a major production-limiting disease in grazing cattle
and sheep. Its control relies heavily on chemical treatment, but the
development of resistance to anthelmintic drugs renders such a strategy
unsustainable and costly when drug failure occurs. Targeted treatment
based on indicators such as FEC, weight gain or observed symptoms such as
diarrhoea, is an approach that should enable efficient control while
generating refugia for drug-susceptible parasite genotypes. However, this
approach is limited by the costs involved in monitoring these types of
treatment indicators. Composite FEC testing offers farmers a more
economical means of monitoring levels of nematode infection in their
livestock. However, the accuracy of composite tests is affected by the
number of individual samples included, how thoroughly the samples are
mixed and the underlying degree of parasite aggregation between individual
hosts. In 2005, Morgan developed methods of optimising the composite FEC
protocol for commercial sheep flocks . He worked in collaboration with
the Animal Health and Veterinary Laboratories Agency (AHVLA) to develop
and validate the composite FEC test (5), which was made available in AHVLA
regional veterinary laboratories in 2006. Another challenge in the
treatment of GIN infection is climate change: variations in parasite
epidemiology in response to climate change make treatment based on
predicted risk of disease increasingly unreliable. In 2008, Morgan
demonstrated that changing seasonal patterns of clinical nematode disease
as a result of climate change , and explained some of the key changes
using a refined understanding of parasite life history. He described for
the first time the detailed influence of temperature on the development,
hatching and survival of larval Nematodirus battus, an
economically important and highly pathogenic sheep parasite . These
novel insights into the ecology of the free-living stages of this parasite
have led to predictive simulation models which are being used to issue
risk forecasts to vets and farmers. These advances have enabled farmers to
better predict and monitor the impacts of GIN on livestock and protect
References to the research
1. Bisdorff B, Milnes A, Wall R (2006) Prevalence and regional
distribution of scab, lice and blowfly strike in sheep in Great Britain. Veterinary
Record 158:749-752. doi:10.1136/vr.158.22.749.
2. Rose H, Wall R (2011) Modelling the impact of climate change on
spatial patterns of disease risk: sheep blowfly strike by Lucilia
sericata in Great Britain. International Journal for
Parasitology 41: 739-746. doi: 10.1016/j.ijpara.2011.01.012.
3. Wall R, Ellse L (2011) Climate change and livestock disease:
integrated management of blowfly strike in a warmer environment. Global
Change Biology 17: 1770-1777. doi:
4. Walters M, Wall R (2012) Evaluation of dicyclanil (CLiKZiN®)
treatment for the early-season protection of ewes against blowfly strike.
Veterinary Parasitology 188: 200-202. doi:
5. Morgan ER, Cavill L, Curry GE, Wood RM, Mitchell ESE (2005) Effects of
aggregation and sample size on composite faecal egg counts in sheep. Veterinary
Parasitology 131: 79-87. DOI:10.1016/j.vetpar.2005.04.021.
6. Van Dijk J, David GP, Baird G, Morgan ER (2008) Back to the future:
developing hypotheses on the effects of climate change on ovine parasitic
gastroenteritis from historical data. Veterinary Parasitology 158:
73-84. doi: 10.1016/j.vetpar.2008.08.006.
7. Van Dijk J, Morgan ER (2008) The influence of temperature on the
development, hatching and survival of Nematodirus battus larvae. Parasitology
135: 269 - 283. doi: 10.1017/S0031182007003812
Funding: To support the work described, funding from Defra, NERC,
BBSRC, FERA and the EU, as well as industry, to the value of £1,151,500
has been awarded, largely through peer-reviewed grants and competitive
Details of the impact
Context: Future agriculture must deliver more food to a growing
global population, but with fewer resources and greater awareness of
environmental impact, as well as changing political and economic paradigms
and a more unpredictable climate. Parasites and disease represent a major
constraint on future production, animal welfare and food security.
Parasites cause debilitating and destructive clinical diseases of
livestock, causing major problems and losses. Research at Bristol into
many of these disease-causing parasites has helped in the development of
targeted controls, and shown how control methods can be adapted to cope
with a changing climate.
Novartis Animal Health incorporates blowfly strike research into
their product advice to farmers: In 2011, Novartis
Animal Health, an international pharmaceutical company specialising in the
prevention and treatment of various widespread animal diseases and
parasite infestations, incorporated Wall's blowfly research into the
advice they provide to farmers regarding the use of some of their products
(B). Wall's research demonstrated the need for early protection of sheep
due to increased strike risk as a result of a lengthening blowfly season.
"Prof Wall's recent findings highlighted not only the importance of
blowfly protection at this time of year," said Helen Langham (C), Brand
Manager at Novartis Animal Health UK Ltd, "but also helped facilitate a
practical solution to the farmer by demonstrating the benefit of a control
strategy using a Novartis product introduced to the market in 2011,
CLikZiN®. Consequently, this work has enabled increased
awareness of the need for early season protection, and together with Prof.
Wall's previous research, will help in the advancement of education within
Also in 2011, Novartis Animal Health sponsored a continuing professional
development course for animal medicines advisers (D), entitled Blowfly
Strike — Early Treatment Best, which is based on Wall's research. As
of 29th October 2012, 375 professionals had completed this
training module (E).
Novartis Animal Health has directly benefited from the research conducted
at the University of Bristol as it has provided evidence to support the
best use of their blowfly strike prevention product, CLikZiN®,
which is ideally suited to early treatment due to its particularly short
withdrawal period. The research has formed the basis for Novartis'
educational material aimed at animal health professionals. CLikZiN®
is used by farmers worldwide, demonstrating the international
applicability of this research.
Sheep and sheep farmers benefit from this research as it not only shows
the efficacy of early treatment with CLikZiN® but also provides
evidence that small changes in husbandry practices can help reduce the
incidence of strike and cut costs. This information has been made
available through numerous mainstream media outlets, such as Farm
Animal Health and Farmers Guardian, farmer meetings and
National Sheep Association events. Better control of this disease will
result in less economic loss for farmers and improved welfare of the
Composite FEC test reduces monitoring costs for farmers and is
incorporated into national recommendations for targeted worm control
strategies of sheep: The composite FEC test, developed by
Morgan in collaboration with AHVLA, has been offered to farmers in the
AHVLA regional veterinary laboratories since 2006. Over 2,000 tests have
been conducted since its introduction (1,563 since 2008) (F). Analyzing
these samples using single tests would have cost farmers £193,812 (based
on the 2012 AHVLA price list), but the composite test cost them only
£52,439 — a 74% saving. As well as this direct reduction in monitoring
costs, farmers save in terms of treatment costs as FEC monitoring can lead
to a decrease of as much as 75% in the number of treatments given to lambs
(G, pg 9). Targeted treatment is a key part of the Sustainable Control of
Parasites in Sheep (SCOPS) initiative of Defra, the National Sheep
Association and Eblex, and is expected to prolong the efficacy of existing
and novel anthelmintic drug classes. Both the composite FEC (H, pgs. 35
& 44; I, recommendation 6) and the risk of autumn nematodirosis (H,
pgs. 5 & 14), based on research at Bristol, are now included in
official recommendations to veterinarians and farmers through SCOPS. SCOPS
published four case studies on farms that adopted the SCOPS principles
between 2007 and 2011, including composite FEC monitoring. All cases
demonstrated the value of FEC monitoring in targeted parasite treatment
(J). In addition, all four farms realized significant improvements in
flock performance after four years of putting all SCOPS recommendations
into practice (J).
Surveys of farmers at Sheep South West Meetings in three separate years
indicate that the uptake of FEC monitoring and the awareness of SCOPS
recommendations are slowly increasing within the industry. Morgan surveyed
232 farmers in 2007, 2009 and 2011. Farmer knowledge of using FEC as a
strategy to slow the development of anthelmintic resistance went from 0%
in 2007 to 1% in 2009 and 13% in 2011 (unpublished data). Knowledge of
SCOPS recommendations, which came out in 2007, improved from 39% in 2009
to 59% in 2011 (unpublished data).
Research at Bristol has also improved disease forecasts, which are
produced by the National Animal Disease Information Service (NADIS) and
distributed by EBLEX to approximately 5,000 (K) producers monthly.
Specifically, Morgan's work on seasonal changes in Nematodirus battus
risk due to climate change has improved spring and autumn disease
forecasts. His work showing the influence of temperature on free-living
stages of N. battus has helped link spring disease more tightly to
temperatures, further improving disease forecasts.
Process leading to impact: Professor Wall and Morgan work actively
to disseminate their research findings to animal health professionals and
ultimately to farmers. Their research is disseminated through: i)
peer-reviewed publications and trade journals; ii) presentations at
meetings with farmers and veterinarians; iii) presentations and attendance
at events such as Sheep South West and National Sheep Association events;
iv) annual SCOPS meetings where Morgan has been invited as an expert; v)
invited talks at the Sheep Veterinary Society; and vi) conferences and
meetings such as the British Association of Veterinary Parasitology. Both
Wall and Morgan work directly with industry and are active invited members
of the advisory boards of international pharmaceutical companies such as
Merial, Bayer, Pfizer and Novartis Animal Health. Wall and Morgan also
work directly with industry and policymakers and have been invited onto
international expert panels to aid policy development in support of
sustainable parasite control and enhanced global food security (L).
In 2013, Wall was awarded the prestigious international WAAVP/Bayer prize
for research excellence, the citation stating that "Professor Richard Wall
has delivered an outstanding and significant contribution to research in
the field of veterinary parasitology."
Sources to corroborate the impact
A. SCOPS (2012) Blowfly strike in sheep. URL: http://archive.defra.gov.uk/foodfarm/farmanimal/diseases/documents/scops-blowfly180507.pdf[Accessed online 15th October 2012].
B. Novartis Animal Health (2011) Recommended usage periods of CLiK®,CLiKZiN®
and CROVECT® for year-round ectoparasite cover.URL:
[Accessed online 7th November 2012].
C. Langham, H. (Brand Manager, Novartis Animal Health UK Ltd.). Letter
June 20, 2012.
D. OvertheCounter (2011) Blowfly Strike — Early
Treatment Best (ID61). URL: http://www.overthecounter.cc/training_modules_view.asp?module=Sheep&id=62
[Accessed online 30th October 2012].
E. Page, L. (Marketing and CPD Training, GH Publishing). Email to N.
Temple. October 29, 2012.
F. White, A. (Access to Information Enquiries Manager, Animal Health and
Veterinary Laboratories Agency).
G. Meat Promotion Wales (2011) The Parasitology Action Plan for Wales
2011: An action plan for the Welsh sheep and beef industry.
H. Abbott KA, Taylor M, Stubbings LA. (2012) Sustainable worm control
strategies for sheep 4th edition: A technical
manual for veterinary surgeons and advisors. Sustainable Control of
Parasites in Sheep. [http://www.scops.org.uk/content/SCOPS-Technical-manual-4th-Edition-June-2012.pdf].
I. SCOPS (2012). Taking the First Steps. URL: http://www.scops.org.uk/taking-the-first-steps.html
[Accessed online 7th November 2012].
J. SCOPS (2012) Case Studies. URL: http://www.scops.org.uk/vets-case-studies.html
[Accessed online 7th November 2012].
K. Lloyd, C. (Industry Development Manager, Eblex). Email to N. Temple.
November 29, 2012.
L. Protecting the Future of Your Flock. Strike Expert Report (2013),
published by Novartis Animal Health — 3000 copies distributed.