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The use and treatment of animals in the provision of our food, clothing and other raw materials, as well as in the areas of medical research, sport and entertainment, polarises public opinion and provokes extreme views. Research by Professor Robert Garner on the ethics and politics of animal protection has provided a springboard for political debate and decision making both in the UK and internationally. In particular, Garner's work has impacted upon the debate within the animal protection movement, and has helped to shape aspects of government policy on animal welfare issues in general, most notably on the UK Government's approach to the issue of whaling, and DEFRA's approach to the ethics of using wild animals in circuses.
Local authorities, the UK government and the European Commission have benefitted from the widespread application of new molecular methodologies, developed in 2005 and applied by the University of Reading's Vertebrate Pests Unit (VPU) to identify and quantify anticoagulant rodenticide resistance in rodent populations. Rodents are a major global pest that consumes our food, causes contamination with urine and faeces, damages structures through gnawing, transmits diseases, and impacts on species of conservation concern. Due to historical success and recent regulatory restrictions, anticoagulant rodenticides are the most common control method for these pests. However, physiological resistance to anticoagulants is now widespread and the VPU has been involved in mapping this resistance and identifying the genetic basis for the resistance. Their research has led to new methodologies to identify anticoagulant resistance that have been adopted by the global plant science industry and to new guidance in treating resistant populations that has been adopted by the European biocides industry.
This case study describes the development, application and commercialisation of an open source tool, BSMBench that enables supercomputer vendors and computing centres to benchmark their system's performance. It comprehensively informs the design and testing of new computing architectures well beyond other benchmarking tools on the market, such as Linpack.
The significance of our code is that, unlike other benchmarking tools, it interpolates from a communication- to a computation-dominated regime simply by varying the (physics) parameters in the code, thus providing a perfect benchmark suite to test the response of modern multi-CPU systems along this axis. The impact of this work has great reach: a start-up company, BSMbench Ltd, has been founded to develop and commercialise the software; adopters have included IBM - one of the giants of the supercomputer world (where it uncovered errors in their compilers); it has been deployed by Fujitsu to validate its systems, by HPC Wales, a multi-site, commercially focussed national computer centre and by Transtec, an HPC company employing over 150 staff; and tutorial articles about BSMBench have appeared in magazines such as Linux Format.
This software tool spawned from our research into "Beyond the Standard Model" (BSM) physics which aims to understand the Higgs mechanism in particle physics at a fundamental level. This involved simulating quantum field theories using bespoke code on some of the fastest supercomputers on the planet.
Professor Zoe Trodd has contributed to changes in antislavery policy debate and practice at local, national and international levels—from lawyers' societies and school teachers, to national non-governmental organisations (NGOs) and the European Parliament—through a series of publications, consultations, public talks, and contributions to teaching and digital resources about contemporary slavery and abolitionism. Drawing on her own research, as well as research into historic forms of slave resistance and literary abolitionism by two other professors in the UoA, she has intervened in contemporary abolitionism by advising the government bodies, NGOs and community organisations working to liberate slaves, pass antislavery legislation and remove slavery from industries' supply chains.
The Abraham solvation parameter approach developed at UCL has become integral to the work carried out by drug discovery teams at [text removed for publication] and other major pharmaceutical companies, as well as research and development groups at international chemical companies including Syngenta and [text removed for publication]. It enables chemists to predict physicochemical and biochemical properties of chemicals, including drugs and agrochemicals, rapidly and efficiently, without the need to conduct time-consuming experiments. The method helps drug discovery teams to identify and optimise the most promising compounds, and often results in fewer compounds being made before a candidate is selected, saving time and resources. The approach has been integrated into software used for drug discovery [text removed for publication].
In partnership with the US company Nalco, the University's Surfactant & Colloid Group developed a new multifunctional technology (Clean n Cor) for the oil industry that both removes accumulated deposits at a metal surface (enabling "break-through" of corrosion inhibitor to the metal surface) and inhibits corrosion. Clean n Cor technology not only protects assets such as oil pipelines against corrosion but also maximises oil production through enhancing water injectivity (water flow per unit pressure drop). Since its launch in 2007, it is currently one of Nalco's fastest growing new technologies and is used at over 100 production locations worldwide.
The performance of absolute distance measuring systems has been improved in terms of accuracy, traceability, reliability and cost through the introduction of new methodology arising from research at the University of Oxford. This has brought commercial benefit to a German company making measurement systems, through the creation of a new product line. New capabilities for measurement have been delivered to a first customer in Germany. The research has also resulted in the establishment of new activity at the National Physical Laboratory, and influenced UK and European technology roadmaps for future manufacturing.
Dr Alexandros Paraskevas has demonstrated the benefits of implementing academic research and `scientific rigour' into global business practices. His conceptual approach to risk and crisis management has become highly acclaimed within the hospitality industry and has strengthened practices in a turbulent business environment. His research pioneered an effective partnership between the Oxford School of Hospitality Management and InterContinental Hotels Group (IHG), resulting in the Group developing new risk management practices, enhancing its effectiveness in managing risks, saving costs and gaining worldwide recognition as industry leader in the field. These practices are continuously shared with the broader H&T industry through appropriate fora and dissemination platforms.
Based in the School of English, the Research and Development Unit for English Studies (RDUES) conducts research in the field of corpus linguistics and develops innovative software tools to allow a wide range of external audiences to locate, annotate and use electronic data more effectively. This case study details work carried out by the RDUES team (Matt Gee, Andrew Kehoe, Antoinette Renouf) in building large-scale corpora of web texts, from which examples of language use have been extracted, analysed, and presented in a form suitable for teaching and research across and beyond HE, including collaboration with commercial partners.
Knowledge of the three-dimensional structures of macromolecules is a prerequisite for understanding their function at the atomic level, an essential component of modern drug development. Most structures are determined by X-ray crystallography: the majority using molecular replacement (MR, which exploits known structures of related proteins), and about half of the remainder using single-wavelength anomalous diffraction (SAD). The Phaser crystallographic software, developed by Read and colleagues, implements powerful new likelihood-based methods for MR and SAD phasing and has made a large impact, accelerating over the period 2008-2013. At the pharma giant, AstraZeneca, Phaser is considered the "tool of choice" for solving structures by MR.