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Application of magnetic nanoparticles in the treatment of breast cancer

Summary of the impact

Groundbreaking UCL research and development of magnetic nanoparticles for biomedical applications led to the introduction in 2012 of the world's first licensed nanoparticulate injectable medical device, the Sienna+ tracer, and its associated detection system, the SentiMag. A UCL spinout company, Endomagnetics Ltd., has introduced this new technology to better diagnose and treat cancer without the need for invasive surgery. The system uses magnetic materials, rather than radioisotopes, to locate the sentinel lymph nodes that are the key indicators of the spread of cancer away from the primary tumour site. As well as improving patient outcomes, the system considerably improves hospital workflow and efficiency since, unlike radioisotopes, the injectable magnetic tracer (Sienna+) is readily available and requires no special handling

Submitting Institution

University College London

Unit of Assessment

General Engineering

Summary Impact Type

Technological

Research Subject Area(s)

Engineering: Biomedical Engineering
Medical and Health Sciences: Neurosciences

C8 - A theoretical prediction leading to a redesigned read head used in all hard-disk drives (HDDs) manufactured today

Summary of the impact

We demonstrate a strong influence on the design of the read head used in the present state-of-the-art hard-disk drive (HDD) first produced commercially in 2008. This much improved read head, enabling disk storage density to increase by a factor of 5 to around 1 Tbit/in2, relies crucially on a magnetic tunnel junction with a MgO barrier whose huge tunneling magnetoresistance was predicted theoretically in a 2001 paper co-authored by Dr A. Umerski [1], the RA on one of our EPSRC-funded research grants. This prediction relied on techniques developed by us over many years, specifically in refs [2] and [3]. Such magnetic tunnel junctions are used in all computer HDDs manufactured today with predicted sales in 2012 amounting to more than $28 billion [section 5, source A].

Submitting Institution

Imperial College London

Unit of Assessment

Mathematical Sciences

Summary Impact Type

Technological

Research Subject Area(s)

Mathematical Sciences: Pure Mathematics
Physical Sciences: Atomic, Molecular, Nuclear, Particle and Plasma Physics
Chemical Sciences: Inorganic Chemistry

Hard disks based on tunneling magnetoresistance

Summary of the impact

Since 2009 the read heads of all hard disks have used a technology based on magnesium oxide (MgO). The development of this technology can be partly attributed to a 2001 publication [3.1] co-authored by Dr Andrey Umerski of The Open University, which concluded that a system based on MgO would lead to a huge increase in magnetoresistance, a physical property that determines the efficiency of hard disk read heads.

In 2004 these theoretical predictions were confirmed experimentally; by 2008 the new type of read head based on MgO was manufactured commercially, leading to significant increases in storage capacity, from GBs to TBs.

Submitting Institution

Open University

Unit of Assessment

Mathematical Sciences

Summary Impact Type

Technological

Research Subject Area(s)

Physical Sciences: Other Physical Sciences
Chemical Sciences: Inorganic Chemistry
Engineering: Materials Engineering

Bomb detection

Summary of the impact

Research at the University of Cambridge, Department of Physics on sensitive techniques for measurements of magnetic and electrical properties of materials led to the selection of Dr Michael Sutherland as an expert witness in a series of major police investigations involving fraudulent bomb detecting equipment. Scientific evidence Dr Sutherland presented in court was key in securing guilty verdicts, leading to the breakup in 2013 of several international fraud rings with combined revenue in excess of £70 million. This criminal activity had caused significant damage to the reputation of the UK in Iraq and elsewhere.

Submitting Institution

University of Cambridge

Unit of Assessment

Physics

Summary Impact Type

Technological

Research Subject Area(s)

Physical Sciences: Atomic, Molecular, Nuclear, Particle and Plasma Physics, Condensed Matter Physics
Chemical Sciences: Inorganic Chemistry

Regulatory Framework for Electromagnetic Field Exposure Limits for Magnetic Resonance Imaging

Summary of the impact

Our research on the physiological effects of the electromagnetic fields generated in magnetic resonance imaging (MRI) has been used by: (i) the International Commission on Non-Ionizing Radiation Protection (ICNIRP) and the UK Health Protection Agency (HPA) in establishing advisory limits and action values in their published regulatory guidelines; (ii) the EU Commission as part of the evidential basis in their decision to derogate MRI from the scope of the Physical Agents Directive 2004/40/EC. These decisions have enabled the continued operation of MR scanners across Europe, safeguarding the access to MRI for 500 million people. The economic benefits arising from the manufacture of MRI equipment were also secured. Our work has thus resulted in impact on public policy, the economy and healthcare.

Submitting Institution

University of Nottingham

Unit of Assessment

Physics

Summary Impact Type

Political

Research Subject Area(s)

Physical Sciences: Other Physical Sciences
Medical and Health Sciences: Clinical Sciences, Neurosciences

International commercial impact from the creation of the spin-out company Magnomatics Ltd.

Summary of the impact

Research in the Department of Electronic & Electrical Engineering at the University of Sheffield has generated economic impact through the creation of a spinout company, Magnomatics Ltd, commercialising high performance electric drives, in particular those employing magnetic gearing technologies. Magnomatics employs 35 full-time staff, had a turnover of £1.4M for the year 2012, and its technologies are now being developed for applications in utility scale wind turbines, hybrid vehicles and marine propulsion.

Submitting Institution

University of Sheffield

Unit of Assessment

Electrical and Electronic Engineering, Metallurgy and Materials

Summary Impact Type

Economic

Research Subject Area(s)

Information and Computing Sciences: Artificial Intelligence and Image Processing
Engineering: Aerospace Engineering, Electrical and Electronic Engineering

Tunneling Magnetoresistance: From theoretical proposal to practical application.

Summary of the impact

The significant increase in hard disk storage capacity in the last few years can be in part attributed to theoretical research in Mathematics undertaken at City University London. A material or device is said to exhibit the property of magnetoresistance if its electrical resistance changes when the direction of an external magnetic field is varied. The work undertaken at City concluded that devices based on magnesium oxide (MgO) would exhibit magnetoresistances very much larger than previously observed. In 2004 these conclusions were confirmed experimentally. By 2008 a new type of disk read head (the device that senses data on a magnetic disk) based on this structure was being manufactured commercially, enabling a significant increase in hard disk storage capacity. Today all computer hard disks use read heads based on this technology in an industry with 2012 sales exceeding $28 billion. The increase in hard disk storage capacity achieved (from gigabytes to terabytes: 1 terabyte = 1,000 gigabytes) and the consequent improvement in disk performance for users can be partly attributed to the City research.

Submitting Institution

City University, London

Unit of Assessment

Mathematical Sciences

Summary Impact Type

Technological

Research Subject Area(s)

Physical Sciences: Other Physical Sciences
Chemical Sciences: Inorganic Chemistry
Engineering: Materials Engineering

CPO software package for designing charged-particle optical systems

Summary of the impact

A software package called CPO has been developed that simulates the motion of charged particles in electromagnetic fields. More than 200 benchmark tests have established CPO as the gold standard in low-energy charged-particle optics. A spin-off company was formed to market CPO, [text removed for publication]

Submitting Institution

University of Manchester

Unit of Assessment

Physics

Summary Impact Type

Technological

Research Subject Area(s)

Physical Sciences: Atomic, Molecular, Nuclear, Particle and Plasma Physics, Other Physical Sciences

Hitachi

Summary of the impact

Research in the Microelectronics Group of the Cavendish Laboratory in the area of single-electron nanoelectronics, quantum computing and spintronics has been exploited by Hitachi, one of world's leading microelectronics companies. Research breakthroughs made in the Cavendish have defined Hitachi's R&D directions in quantum computing and spintronics, led to several Hitachi product developments and influenced senior Hitachi strategic decision makers regarding the future of computing.

Submitting Institution

University of Cambridge

Unit of Assessment

Physics

Summary Impact Type

Technological

Research Subject Area(s)

Physical Sciences: Atomic, Molecular, Nuclear, Particle and Plasma Physics, Other Physical Sciences
Engineering: Materials Engineering

Electric Potential Sensor Technology – From Fundamental Physics to Product

Summary of the impact

A ground-breaking range of innovative sensor products — the EPIC Sensors — has been developed and marketed world-wide by Plessey Semiconductors Ltd. The EPIC Sensors allow contact-free measurements of electric phenomena, initially aimed at the health, sports and automotive markets. They operate on the non-invasive, low-cost, generic, award-winning Electric Potential Sensor (EPS) technology invented and developed at Sussex as a spin-off from fundamental low-temperature physics research. Income to the University from licence fees, costs and royalties started during 2012. Sustained industry engagement with key strategic partners in the medical, forensic, security, materials testing and geophysics sectors, including government organisations, industry and academia, is leading to a wider awareness and adoption of this novel technology.

Submitting Institution

University of Sussex

Unit of Assessment

Physics

Summary Impact Type

Technological

Research Subject Area(s)

Engineering: Electrical and Electronic Engineering
Medical and Health Sciences: Neurosciences

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