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The EU REACH regulation 2007 (Registration, Evaluation, Authorisation and restriction of Chemicals) requires producers and importers of chemicals to register them and provide information to ensure their safe use whilst minimising the use of animal testing. When the White Paper on REACH was published in 2001, over 90% of the 100,000+ chemicals in use had few or no toxicological data available. In order to address the deficiency in the ability for companies to comply with these regulations, LJMU has developed a suite of computational tools to predict toxicity of chemicals using only knowledge of chemical structure and properties. These models have been incorporated into predictive software including the OECD (Organisation for Economic Co-operation and Development) QSAR Toolbox which is promoted by the European Chemicals Agency (ECHA), as a useful means to provide information for REACH dossiers and has been taken up by industry internationally for this purpose.
Research at the University of Leeds has underpinned the company Lhasa Ltd. which has made widely available the toxicity prediction software currently known as Derek Nexus. The use of Derek Nexus by large pharmaceutical companies to support drug development is effectively universal. Toxicology prediction software has led to changes in guidelines issued by regulatory authorities and to industry-wide changes to the investigation of the toxicity of trace impurities. These changes have reduced the resources needed for experimental investigation of toxicity, and have increased revenues derived from launched drugs by extending their patent period of exclusivity. Lhasa Ltd. derives income in support of its charitable aims from Derek Nexus , and a related product Meteor Nexus (Meteor) also based on research undertaken in Leeds. The company reported revenues over £5.4M in 2012 and employs 71 highly qualified staff.
The safe operation of ships is a high priority task in order to protect the ship, the personnel, the cargo and the wider environment. Research undertaken by Professor Alexander Korobkin in the School of Mathematics at UEA has led to a methodology for the rational and reliable assessment of the structural integrity and thus safety of ships and their cargos in severe sea conditions. Central to this impact is a set of mathematical models, the conditions of their use, and the links between them, which were designed to improve the quality of shipping and enhance the safety of ships. The models, together with the methodology of their use, are utilised by the ship certification industry bringing benefits through recognised quality assurance systems and certification.
From 2008-2010, Peter Murray-Rust developed a Chemistry Add-in for Microsoft Office Word, which enables users to insert and modify searchable, semantically rich chemical information within a Microsoft word document and for the data to be stored and manipulated in a semantically rich manner. The Add-in has been downloaded over 400,000 times. It was one of the first projects from Microsoft Research for which a public release under an open source license was obtained. This project demonstrated to a wide audience new semantic approaches to computing in chemistry. Chem4Word has impacted on education, publishing and science in industry and academia.
The safety assessment of drugs and other chemicals relies upon studies in experimental animals. Whilst these are useful surrogates, extrapolation to humans requires several assumptions. Professor Boobis led an international group under the auspices of the World Health Organisation (WHO), to develop a framework for the systematic and transparent assessment of such experimental data. Within this framework, the toxicological effect of a chemical is broken down into a series of intermediate steps, comprising a mode of action. This enables qualitative and quantitative comparison between experimental animals and humans. The framework has impacted on risk assessment policy both nationally and internationally, on product development, and on risk assessments of combined exposure to chemicals.
Ground breaking and unique research carried out at the Centre for Skin Sciences at the University of Bradford has led to the realization of commercial opportunities in two very high-value consumer brands. Technologies developed in collaboration with multi-national personal-care and cosmetic companies for the treatment of skin hyper-pigmentation have been launched on the market and have reached thousands of consumers. The first product launched by Alliance-Boots (April 2012) is sold within the UK's premier skincare range (No. 7). Success in Britain led to its launch in the US, Finland and Thailand. A second product within the Diorsnow range has been launched by Parfum Dior — a branch of LVMH Moët Hennessy • Louis Vuitton S.A.
Hundreds of synthetic chemicals contaminate our food and water. Brunel's research shows harmful cumulative cocktail effects of low levels of contaminants in food and water, previously thought to be safe. The active translation of these results into European chemicals legislation also ensured a sound basis for including multiple chemical exposures in risk assessment. By working with the European Food Safety Authority, we demonstrated a viable approach to grouping chemicals for mixtures risk assessment. Based on our research, a totally new approach to grouping chemicals for mixtures risk assessment has been decided. This will influence maximum residue levels for toxic pesticides in food in Europe leading to better protection of consumers against the increased risks of harm due to multiple pesticide residues present in the majority of food items.