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J: Elective delivery of pregnant women reduces perinatal mortality, particularly in mothers over 40 years of age

Summary of the impact

Impact: Health and welfare; healthcare guidelines on elective induction of labour. The research showed that elective induction at time points from 37 weeks' gestation progressively reduces perinatal mortality. UK guidelines now recommend routine induction at 39 weeks in mothers >40 years of age.

Significance: Implementation of the guidelines for mothers >40 years of age is estimated to prevent the stillbirth of 17 babies per year in the UK.

Beneficiaries: Pregnant women, policy makers and healthcare providers.

Attribution: The work was led by Jane Norman with Sarah Stock at UoE, in collaboration with NHS Information Scotland.

Reach: UK, Europe, North America. Applies to all pregnant women, especially those over 40 years of age.

Submitting Institution

University of Edinburgh

Unit of Assessment

Clinical Medicine

Summary Impact Type

Health

Research Subject Area(s)

Medical and Health Sciences: Paediatrics and Reproductive Medicine, Public Health and Health Services

K: Progesterone does not prevent preterm birth in twin pregnancy (STOPPIT study)

Summary of the impact

Impact: Health and welfare; public policy; the work led to UK and international guidelines advising against progesterone use to prevent preterm birth in twin pregnancy.

Significance: Thousands of women now avoid this unpleasant procedure annually, with a saving to the NHS of £25M.

Beneficiaries: Pregnant women, policy-makers, the NHS and healthcare-providers.

Attribution: The work was initiated by a five-centre UK collaborative group including UoE. Data analysis, interpretation and translation into practice were led by Jane Norman, UoE.

Reach: The data are cited in guidelines and have changed clinical practice on three continents: Europe (NICE), North America and Australasia. Applies to 11,000 women annually in UK alone.

Submitting Institution

University of Edinburgh

Unit of Assessment

Clinical Medicine

Summary Impact Type

Health

Research Subject Area(s)

Medical and Health Sciences: Paediatrics and Reproductive Medicine

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