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Clinical research conducted at the UCL Institute of Child Health between 1998 and 2011 under the direction of Professors Alan Lucas and Atul Singhal showed that a slower rate of infant weight gain had long-term benefits to reduce the risk of obesity and cardiovascular disease. This contradicted the accepted view, which favoured the promotion of rapid weight gain in infancy. This work has had a significant influence on public health policies and initiatives in the UK and elsewhere. It has changed the way infant formulas are made and used. Two new interventions for overweight children have been developed and are helping families around the world.
Around 25% of UK adults have high blood pressure (hypertension), accounting for more than half of all strokes and heart disease. The pressure that the heart and brain senses that leads to these diseases is central aortic pressure. The Unit's research developed and evaluated methods for the non-invasive assessment of central aortic pressure, demonstrating its important relationship to clinical outcomes. The work has contributed to improvements in the way high blood pressure is treated for millions of people, nationally and worldwide, by (i) providing a rationale for one of the biggest-ever changes in treatment guidance in 2006; (ii) stimulating major growth in medical devices for the non-invasive measurement of aortic pressure with a simple, easy-to-use wristwatch invention; (iii) and developing central aortic pressure as a better biomarker for pharmaceutical companies to develop new drugs to treat hypertension.
Research in the Oxford University Clinical Research Unit (OUCRU) in Vietnam have spent the past two decades defining effective management strategies for dengue, which is the most significant mosquito-borne viral disease in humans. Dengue affects an estimated 50 million people and kills over 22,000 patients (mainly children) worldwide each year. OUCRU research directly underpins the clinical practice guidelines worldwide for the treatment of dengue shock syndrome (DSS), including the World Health Organization's (WHO) 2009 Dengue Guidelines, leading to faster, more effective and safer resuscitation of affected individuals.
Professor Dieter Wolke has led several research programmes that delineate the long-term health effects of prenatal exposure to stress and moderate/late preterm, very preterm, and extremely preterm birth. His research has had a direct impact on international medical guidelines and educational recommendations for babies born preterm. The research has also informed European political debate (via a White Paper for the European parliament) on healthcare policy related to after care for preterm or sick children; has influenced UK policy regarding the education of children born preterm; and has contributed to public and practitioner understanding through media items issued, for example, by the NHS and the Royal College of Obstetricians and Gynaecologists.
MacGregor and colleagues working at St George's have provided extensive clinical and epidemiological evidence that has changed UK government policy on recommendations for salt intake. In 2011 NICE recommended continued reduction in dietary salt intake in the UK. A 3 gm reduction in daily salt intake is calculated to result in 14-20,000 fewer deaths from cardiovascular disease annually, a saving of approximately £350 million in healthcare costs, and the gain of 130,000 quality-adjusted life years. The global benefits of this policy have been recognised with the WHO making recommendations for similar levels of salt reduction worldwide.
The UK infant formula market increased in value from 2005-2013 by 65% to £463m. The Unit's research, funded by the Food Standards Agency and the Department of Health, addressed the concerns of policy makers and breast feeding lobby groups that baby food manufacturers might be circumventing recently introduced restrictions on advertising infant formula (breast milk substitute) products in such a way as to undermine support for, and uptake of, breastfeeding. The research findings underpinned the recommendations on regulatory change made to government by an independent review panel established by the Minister of State for Public Health. Since the panel reported, manufacturers have addressed the issue by removing publicly accessible links to infant formula product information.
Research at Kingston University led to the development of a preschool number learning scheme ("PLUS") which uses short matching and estimation games to improve the number abilities of preschool children. The programme was first delivered by trained postgraduate students to 60 children at five regional nursery schools. An evaluation study confirmed the efficacy of the programme in enhancing the children's numerical (and other) skills. Next, Dr Van Herwegen trained staff members in these five preschools and five others to deliver PLUS on a daily basis, to reach over 500 pre-schoolers across the region. This resulted in a change to institutional practices within these preschools.