Summary of the impact

Schizophrenia affects 1 in 100 people, with costs to society of £12 billion in England alone. Prevalence is similar across the world, with two thirds of people experiencing relapses despite medical treatment. Researchers at the University of Manchester (UoM) pioneered and disseminated psychological interventions for schizophrenia and related mental health problems which have led to improved outcomes for patients and families (e.g. 20% improvement in symptoms over standard treatment). We have implemented and delivered our intervention protocols, outcome measures, treatment manuals, and training programmes (with over 200 training courses delivered across the UK, Europe, USA, Asia, Australia and Africa). The impact of the research has been commended nationally and internationally by professional bodies (e.g., British Psychological Society, American Association of Behavior Therapy).

Summary of the impact

University of Glasgow researchers have played a pivotal role in enhancing awareness and understanding of cosmology, relativity and gravitational-wave astronomy on the national and international stage.

• The 'Astronomy's New Messengers' public exhibition on gravitational-wave astronomy has been displayed at international events that have attracted a total audience exceeding a million people. A survey conducted at the World Science Festival 2010 indicated that 89% of visitors found the exhibition had increased their interest in science.
• The University of Glasgow has had a crucial influence on the redesign of the Scottish Higher and Advanced Higher Physics syllabus to include significant content on cosmology, relativity and gravitational astrophysics. In 2012 the revised Higher Physics pass rate was approximately 4% greater than that for the non-revised Higher, demonstrating significant impact in terms of pupil engagement and results.

Summary of the impact

Many of the millions of people worldwide with disfigurement face significant psychological challenges. Research at UWE's Centre for Appearance Research (CAR) has made a substantial contribution to the interventions and healthcare provision available for patients with the most common congenital disfigurement — cleft lip and palate — in the UK and internationally. Specifically, our research has underpinned: (1) The inclusion of psychologists as key members of all UK cleft teams; (2) The development of effective forms of psychological support and interventions currently in use by psychologists and charities across the UK and abroad; (3) The development of evidence-based training packages currently being used by practitioners across Europe.

Summary of the impact

Building on research in integrated information systems and their impact on organisational culture, Newcastle Business School (NBS), via a two-year Knowledge Transfer Partnership (KTP 8193), assisted Inpipe Products (IPP) to increase its operational efficiency and turnover. IPP is a world leading company in the design, manufacture, supply and rental of pipeline maintenance equipment for the global oil and gas industry. The KTP explored and developed the cultural environment for successful implementation of an integrated information system. The result for the company is improved operational efficiency, with the processing time for products from sales to engineered drawings reduced from five hours to 15 minutes, a reduction in late deliveries due to better information on product specification and a 14% reduction in rejected products. Product sales turnover has increased from £5.5 million to £6 million per year.

Summary of the impact

Although, by definition, individually rare, the cumulative burden of `rare disease' is significant, with as many as 3m affected individuals in the UK. The University of Manchester (UoM) has an exceptional record in rare disease gene identification, with 29 such genes defined since 1993. This research paved the way for clinical diagnostic testing for patients and their families, demonstrating the immediate translational impact of gene discovery. The research has resulted in a reduced diagnostic burden for patients and health services and has enabled the provision of more effective counselling. Testing for genes identified at UoM is now offered in more than 140 laboratories in more than 30 countries worldwide. More than 1,100 patients have been tested for mutations in TCOF1, BEST1, IRF6, SAMHD1 and C9ORF72 in UK NHS laboratories alone.

Summary of the impact

Cranfield has improved modelling and simulation capability in the infrared and radio frequency regions of the electro-magnetic spectrum. This research has been exploited by Chemring in:

• a product improvement plan for a highly detailed modelling suite that enables the assessment of air, land and maritime missile and target engagements with particular emphasis on the efficacy of the countermeasures deployed by the target.
• insights in specific areas of countermeasure product development such as the desirability and efficacy of release of the countermeasure before the threat has been detected.

Cranfield's research has also contributed to a major new Chemring hardware product called the Centurion launcher, by informing the development of the software algorithms to control the launcher in operation.

Summary of the impact

A sustained joint research partnership with Biocompatibles UK Ltd has stimulated innovation underpinning the company's product development pipeline. Products include a family of soft contact lenses, enhanced medical device coatings, and novel treatments for liver cancer. Innovative enhancements, such as the unique non-biofouling nature of the company's ocular and cardiovascular devices and the practical utility of its drug eluting therapies for targeting liver malignancies, have delivered improved clinical performance and differentiated these products from those of competitors in the same markets. The company's continuing success in developing innovative medical technology products was recognised by the sale of Biocompatibles UK for £177m in 2011.

Summary of the impact

The development of the chemistry of Selectfluor® (F-TEDA-BF₄) has resulted in this Manchester-discovered reagent becoming the world's most widely used commercial electrophilic fluorinating agent to introduce fluorine into a range of pharmaceuticals and agrochemicals. Annual worldwide production is ca. 25 tonnes and sales estimated to be US$7.5m. Selectfluor is used in the synthesis of fluticasone, a fluorinated corticosteroid which is the active ingredient in GSK's Advair ($3.6bn sales in 2010) used in the treatment of asthma and chronic obstructive pulmonary disease symptoms; top 25 selling drugs Flixonase, Flixotide, Flonase, Flovent HFA and Advair Diskus which had total sales of over $17bn between 2009-2012.

Summary of the impact

This case study reclaims neglected writers and texts, enabling user engagement with British literary heritage through the commemoration, interpretation and presentation of authors' lives and forgotten or rare fiction. It expands cultural capital and enhances the imaginations and understanding of individuals and groups by raising awareness of the lives and literature of non-canonical Victorian and Edwardian writers. Using previously unexamined archival and privately-held source material it challenges previous assumptions about, for instance, disability and invalidism in relation to Victorian women writers. Through cultivating interest in, and enabling public knowledge of, such authors and their work it creates cultural and educational enrichment.

Summary of the impact

Negative body image affects 60-70% of children and adults in developed countries and is recognised as a significant public health issue. UWE research has influenced national parliamentary policy debate and advocacy campaigns, including the report of the All-Party Parliamentary Group on Body Image. It has also directly shaped the global social mission agenda of Dove, Unilever's largest personal care brand. It has convinced Dove's key business stakeholders of the viability of evidence-based approaches to improving body image in educational settings, and subsequently underpinned Dove's body image education curriculum, which is delivered in more than 20 countries worldwide.