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Wills Catalysts: commercialised systems for enantioselective production of pharmaceutical intermediates

Summary of the impact

A process for the commercial production of a family of Warwick-invented organometallic catalysts has been developed and patented by Johnson Matthey (JM). The catalysts — which have been sold internationally to several fine chemical and pharmaceutical companies in kilogram quantities, capable of producing tonnes of product — are in widespread industrial use for synthesis and scale-up. Other companies have protected, and are marketing, similar `copycat' catalysts. JM continues to work in collaboration with Warwick Chemistry on the next generation of catalysts.

Submitting Institution

University of Warwick

Unit of Assessment

Chemistry

Summary Impact Type

Technological

Research Subject Area(s)

Chemical Sciences: Organic Chemistry, Physical Chemistry (incl. Structural), Other Chemical Sciences

Industrially relevant olefin polymerisation catalysis at UEA

Summary of the impact

Research at UEA over a 20 year period in the area of olefin polymerisation catalysis has had significant economic impact through:

  • industrial uptake of new activator systems crucial for solution phase polymerisation processes
  • improvement in catalyst performance by the `trityl effect' which is now implemented in industrial processes
  • patents taken out and maintained by industry.

Submitting Institution

University of East Anglia

Unit of Assessment

Chemistry

Summary Impact Type

Technological

Research Subject Area(s)

Chemical Sciences: Inorganic Chemistry, Physical Chemistry (incl. Structural), Other Chemical Sciences

UOA08-01: Oxford Catalysts Group – a successful company built on the development and application of highly-active catalysts for the conversion of natural gas to liquid hydrocarbons

Summary of the impact

Research carried out by Malcolm Green's group in the UOA led to the spin-out of Oxford Catalysts Ltd. A large part of the company's technology is based on Green's transition-metal catalysis research, which has enabled them to develop a highly efficient Fischer-Tropsch (FT) catalyst to convert natural gas to liquid hydrocarbons. In 2010, Oxford Catalysts Group (now Velocys) demonstrated the world's first smaller-scale, modular gas-to-liquids and biomass-to-liquids FT plants which made use of the catalyst for the efficient conversion of low-value or waste gas to liquid hydrocarbon fuels. Since then, orders worth £ 8M have been taken and the company has been selected to provide FT technology for 4 commercial projects. From 2008 - 2012, the company raised over £ 60M, achieved revenue of £ 30M and now employs around 90 people.

Submitting Institution

University of Oxford

Unit of Assessment

Chemistry

Summary Impact Type

Technological

Research Subject Area(s)

Chemical Sciences: Inorganic Chemistry, Physical Chemistry (incl. Structural), Other Chemical Sciences

Replacement of heavy metal catalysts in the plastics industry

Summary of the impact

Catalysis is a major UK industry strength and wealth generator for the UK economy. Research carried out in the group of Professor Matthew Davidson in the Department of Chemistry at the University of Bath resulted in the development of titanium and zirconium alkoxide catalysts for use in three industrial polymerisation processes and patented by the UK companies ICI Synetix and Johnson Matthey. Patents have recently also been acquired by the Indian multinational Dorf Ketal and filed by the Dutch multinational Corbion Purac. The research has resulted in the adoption of new catalysts in industry leading to increased turnover, onward dissemination and implementation of the Bath intellectual property. It has also generated £4.6M from sale of intellectual property and an increase in generated sales of new, sustainable titanium catalysts that replace heavy metals such as tin, antimony and mercury in major industrial processes. The intellectual property and process developments have been implemented globally in the poly(ethylene terephthalate) (PET) and poly(urethane) (PU) plastics markets, worth $23B and $33B, respectively, in 2010.

Submitting Institution

University of Bath

Unit of Assessment

Chemistry

Summary Impact Type

Technological

Research Subject Area(s)

Chemical Sciences: Inorganic Chemistry, Organic Chemistry, Other Chemical Sciences

C3 - Plaxica: Transformational Biopolymer Technology

Summary of the impact

Plaxica is a spin-out from, and based, at Imperial College London with economic, societal and environmental impacts. Launched in 2008, Plaxica is a process technology licensing business which is tackling the barriers that currently prevent a wider acceptance of bioplastics; specifically improving properties, decreasing cost and using non-food feedstocks to manufacture the biopolymer poly(lactic acid), PLA. Plaxica's technology uses sustainable feedstocks to produce PLA using more energy-efficient processes, to produce a strong, high-quality polymer, the result of which is a low-cost, environmentally-friendly biopolymer for use in applications including textiles, packaging, and automobile parts. In the REF period Plaxica has raised £10m from investors such as Imperial Innovations, Invesco Perpetual and NESTA Investments. The market pull for biorenewable materials from consumers is strong and the EU predicts that PLA will substitute >10% of the existing market for petrochemical polymers and forecasts a market >$15b [A].

Submitting Institution

Imperial College London

Unit of Assessment

Chemistry

Summary Impact Type

Technological

Research Subject Area(s)

Chemical Sciences: Inorganic Chemistry, Macromolecular and Materials Chemistry, Other Chemical Sciences

Catalytic Converter Research Leads to Major New Product for Motor Vehicles

Summary of the impact

Globally there are estimated to be 60 million cars produced each year. These all require catalysts that need testing to meet stringent emissions legislation. Catagen Ltd, a spin-out from Queen's University has developed a product for testing motor vehicle catalysts that is 85% cheaper to operate than traditional methods and represents a 98% reduction in CO2 emission from testing and an 80% reduction in energy input.

Major global customers including GM motors and Fiat have adopted this revolutionary patent protected technology and international sales growth has been recognised, winning an all- Ireland business award for BEST High Growth Company 2012

Submitting Institution

Queen's University Belfast

Unit of Assessment

Aeronautical, Mechanical, Chemical and Manufacturing Engineering

Summary Impact Type

Technological

Research Subject Area(s)

Chemical Sciences: Inorganic Chemistry, Macromolecular and Materials Chemistry, Physical Chemistry (incl. Structural)

1. Enabling the cost-effective and environmentally friendly production of Perspex

Summary of the impact

Cardiff University, through developing and patenting a commercially viable synthetic route to a catalyst, has enabled the application of a new process, the Alpha Process, for the production of methyl methacrylate (MMA), a key commodity precursor to Perspex. The Alpha Process has had economic and environmental impacts.

Lucite International, the world's leading MMA producer, has invested in major Alpha Process production facilities in Singapore and Saudi Arabia, benefitting from a production route which is more efficient, more reliable and cheaper than conventional routes.

The Alpha Process also brings environmental benefits, as it does not rely on the use of corrosive and toxic feedstocks, such as hydrogen cyanide, which are associated with conventional MMA processes.

Submitting Institution

Cardiff University

Unit of Assessment

Chemistry

Summary Impact Type

Technological

Research Subject Area(s)

Chemical Sciences: Inorganic Chemistry, Organic Chemistry, Other Chemical Sciences

C1 - The Founding of Argenta Discovery and Pulmagen Therapeutics

Summary of the impact

The growth and performance of Biofocus Galapagos Argenta (BGA) and Pulmagen Therapeutics (PT) are underpinned by research from the Imperial-based TeknoMed project that started in 1997. BGA was formed in 2010 through the acquisition of Argenta Discovery (AD) by Biofocus Galapagos for €16.5 million and is one of the world's largest drug discovery service organisations with 390 plus employees and turnover of €135 million [section 5, A]. PT was formed as a separate company to own the complete AD drug pipeline. It develops new medicines to treat asthma, cystic fibrosis and allergic diseases. In 2011 BGA signed agreements with PT for an initial £6million fee and with Genentech for £21.5million.

Submitting Institution

Imperial College London

Unit of Assessment

Chemistry

Summary Impact Type

Technological

Research Subject Area(s)

Chemical Sciences: Inorganic Chemistry, Organic Chemistry, Other Chemical Sciences

Biocatalysis integrated with chemistry and engineering to speed development of green pharmaceutical processes (BiCE programme)

Summary of the impact

UCL research has been instrumental in creating critically needed new biocatalysts and bioprocess technologies for industrial biocatalytic process development. These have impact across the UK chemical and pharmaceutical sectors. BiCE enzyme technologies have been exploited through the formation of a spin-out company, Synthace, generating investment of £1.8m and creation of 7 new jobs. Commercial utilisation of BiCE enzymes by company partners has led to environmental benefits through sustainable syntheses and reduced waste generation. BiCE high-throughput bioprocess technologies have also been adopted to speed biocatalytic process development. UCL established a parallel miniature stirred bioreactor system as a new product line for HEL Ltd. [text removed for publication]. Related knowledge transfer activities have also benefited some 157 industrial employees from over 50 companies since 2008.

Submitting Institution

University College London

Unit of Assessment

Aeronautical, Mechanical, Chemical and Manufacturing Engineering

Summary Impact Type

Technological

Research Subject Area(s)

Chemical Sciences: Inorganic Chemistry, Organic Chemistry, Physical Chemistry (incl. Structural)

Ingenza Ltd; Technologies for new catalysts and products across the industrial biotechnology spectrum

Summary of the impact

Impact: Economic. Ingenza is a profitable SME based in Roslin, Scotland, with 34 (12 PhD-level) staff, and a turnover of £2.7M in 2012-13.

Significance: Ingenza Ltd is an established industrial biotechnology (IB) and synthetic biology (SB) company which incorporated in September 2002. Its combination of synthetic organic chemistry with efficient methods of genetic screening, fermentation and engineered microbial strains is used to develop competitive and scalable industrial bioprocesses for pharma, chemicals, energy, natural product and other industry sectors.

Beneficiaries are Ingenza's customers (commercial and the public) and its employees.

Research; date; attribution: In 2002 the Turner group (University of Edinburgh, UoE) published in Angew. Chem. a new strategy of integrated chemo- and enzymatic catalysed routes to high-value chiral compounds that offered dramatic improvements over existing technologies (high yield and enantiomeric excesses often > 99.9%).

Reach: Ingenza now has moved from a focus on fine chemicals to establish long term technology development and licensing agreements with global leading end-users in the chemicals, polymers, biofuels, food and biologics sectors, for example in the sustainable manufacture of poly-methylmethacrylate with Lucite International.

Submitting Institutions

University of St Andrews,University of Edinburgh

Unit of Assessment

Chemistry

Summary Impact Type

Technological

Research Subject Area(s)

Chemical Sciences: Organic Chemistry, Other Chemical Sciences
Biological Sciences: Biochemistry and Cell Biology

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