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Local authorities, the UK government and the European Commission have benefitted from the widespread application of new molecular methodologies, developed in 2005 and applied by the University of Reading's Vertebrate Pests Unit (VPU) to identify and quantify anticoagulant rodenticide resistance in rodent populations. Rodents are a major global pest that consumes our food, causes contamination with urine and faeces, damages structures through gnawing, transmits diseases, and impacts on species of conservation concern. Due to historical success and recent regulatory restrictions, anticoagulant rodenticides are the most common control method for these pests. However, physiological resistance to anticoagulants is now widespread and the VPU has been involved in mapping this resistance and identifying the genetic basis for the resistance. Their research has led to new methodologies to identify anticoagulant resistance that have been adopted by the global plant science industry and to new guidance in treating resistant populations that has been adopted by the European biocides industry.
Karl Gerth's work on the role of Chinese consumers in the global economy, and on ways in which Chinese consumerism may create more environmental and policy problems than it solves, has had a significant influence on business leaders seeking to position themselves in the Chinese market, as well as on public discourse around the `rise of China'. Gerth has extended the range and quality of the evidence on the interconnected and wide-ranging ramifications of the shift within China toward a market economy over the past thirty years, and has improved understanding of this phenomenon in ways which have enabled British business to compete more effectively in China.
Research in materials modelling by the Computational Science and Engineering Group (CSEG) is helping aerospace, defence and transport companies design advanced materials and new manufacturing processes. From lightweight components like aeroengine turbine blades to the control of magnetic fields to stabilise the next generation of International Space Station levitation experiments, CSEG is supporting innovations which have:
In the assessment period, CSEG collaborated closely with leading industries in steel-making (ArcelorMittal, Corus), primary aluminium (Dubal, Rusal, Norsk-Hydro, SAMI) and lightweight structural materials for transport and aerospace (European Space Agency, Rolls-Royce).
Ultra-precise Bragg grating writing-technology, invented in the Optoelectronics Research Centre (ORC), has led to impacts in the areas of security, safety, detection of bio-hazards and the underpinning laser technology currently being pursued for clean energy generation for future energy security. This case study highlights two aspects of the technology namely: planar-based for optical microchip sensors in areas such as portable detection of biohazards, which has resulted in the spin-out Stratophase, and fibre-based, inside the US National Ignition Facility (NIF), the world's largest laser system, based in California, built for fusion-energy research, which has ORC fabricated fibre Bragg gratings within its laser amplifier chains. These ultra-high precision laser-written engineered gratings have enabled important advances in biosecurity, management of environmental hazards and clean energy research.
High-profile cases of growth hormone misuse by leading international sports stars have made the development of an effective detection test a main priority of global anti-doping organisations. A research team headed by the University of Southampton developed a new test, adopted at the 2012 Olympic Games, which identified two drugs cheats at the London Paralympic Games just weeks after it was first introduced. The subsequent bans serve to act as a powerful deterrent to other athletes and help restore public confidence in fair competition. The World Anti-Doping Agency has announced its commitment to rolling out the test internationally.
Increased understanding of how a member state can influence the EU created two kinds of impacts: changing thinking, understanding and awareness (e.g. HM Treasury); and changing strategy and policy (e.g. EU Committee of Regions). Impacts were generated between 2008 and 2012 on the Polish Government, the Swedish International Development Agency, the US Depository Trust and Clearing Corporation, civil servants in Ukraine, Russia and the UK, the European think tank community, the Labour Party and the EU's Committee of the Regions. Impact was generated through consultancies to public bodies and by providing advice to governments, international organisations and the private sector.
This case study demonstrates how research into Object Orientated programming has resulted in a feature-rich e-commerce platform that has transformed the management and operations of a traditional sheet music company (Faber Music) and its expanding business partner network.
Impact includes:
Measurement of hormones is essential to the understanding and diagnosis of endocrine diseases. White and her research group have developed unique antibodies that are widely used in diagnostic assays for adrenocorticotrophic hormone (ACTH) and related peptides, including the first and only kit for measuring pro-opiomelanocortin (POMC), the precursor of ACTH. These assays are used worldwide for diagnosis, decisions on treatment, monitoring for recurrence of tumours and prognosis in a number of patient groups with life-threatening endocrine disorders. Global sales of the ACTH Elecsys tests by Roche exceeded 6 million kits since 2008. AstraZeneca has used the POMC and ACTH assays in its drug discovery programmes in the cardiovascular and metabolic diseases therapy area. The antibodies therefore have had health impact in relieving suffering and in improving patient care, as well as commercial impact in worldwide sales of assays and influencing drug development strategies.
The Arctic is undergoing faster rates of climate change than most other regions of the world, with major global consequences. Since the 1990s, Professor Callaghan and co-workers at Sheffield have been at the forefront of determining climate change impacts on Arctic ecosystems. This research has directly led to, and fed into, invited authorship and major co-ordination roles in the authoritative international synthesis reports on climate change impacts commissioned by the Arctic Council and the Intergovernmental Panel on Climate Change (IPCC). Through these reports our findings have been widely communicated to international policymakers, the media and society. Callaghan and colleagues have provided policy advice directly to ministers, ambassadors, climate negotiators, and other leaders through face-to-face meetings and presentations, and influenced policy debates at regional to international levels. They have actively engaged in knowledge- exchange activities with Arctic indigenous societies, which are improving those societies' strategies for adaptation to climate change. Through public lectures, the media and authorship of a commissioned textbook, the Sheffield research findings have increased public understanding and influenced the A-level Geography curriculum.
Protecting London from the threat of flooding is of prime importance to the nation. Work in the Unit on regional sea-level rise and on the effect of storm surges was used in the Environment Agency's Thames Estuary 2100 (TE2100) plan to assess potential change in risk. The Unit's work estimated a very unlikely maximum rise in sea level of 2.7m by 2100, considerably lower than the previous worst-case scenario of 4.2m. It confirmed that 90 centimetres was the figure that should be used for developing the plan. TE2100 concluded that a second Thames Barrier (estimated cost £10-20 billion at today's prices) would not be needed not by 2030, but may be needed by 2070. Our results have been used to define procedures for the monitoring of regional sea and Thames water levels over the next few decades, and to review decision-making procedures to ensure that the risk of flooding in London is kept within acceptable levels, while avoiding unnecessary costs