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Knowledge of the three-dimensional structures of macromolecules is a prerequisite for understanding their function at the atomic level, an essential component of modern drug development. Most structures are determined by X-ray crystallography: the majority using molecular replacement (MR, which exploits known structures of related proteins), and about half of the remainder using single-wavelength anomalous diffraction (SAD). The Phaser crystallographic software, developed by Read and colleagues, implements powerful new likelihood-based methods for MR and SAD phasing and has made a large impact, accelerating over the period 2008-2013. At the pharma giant, AstraZeneca, Phaser is considered the "tool of choice" for solving structures by MR.
Two books and review/research articles in Italian have disseminated the findings from the underpinning research on creating false autobiographical memories and the dangers of inadequate interviewing techniques. This work has critically increased awareness in the Italian legal system amongst both barristers and judges, to the point of shaping the practice of interviewing witnesses in that country. It has also informed all verdicts on child sexual abuse by the Supreme Court of Cassation.
Professor Hani Hagras' research into type-2 Fuzzy Logic Controllers (FLCs) underpins novel control systems which avoid the drawbacks and shortcomings of the type-1 FLCs used in numerous real world applications. Type-2 FLCs, developed at Essex, enable challenging applications to be realised and managed with better accuracy and robustness. Such applications include:
Research to quantify the ecological structure and spatial dynamics of terrestrial habitats in Northern Ireland (NI), and to assess the effects of recent land use change, has enabled the Northern Ireland Environment Agency (NIEA) to develop and implement a science-based strategy for landscape-scale biodiversity management and conservation. It has directly facilitated the integration of NIEA and the Department of Agriculture for NI (DARD) biodiversity management strategies and their monitoring of the implementation of European Community biodiversity legislation (and cross-compliance).
The science information-base and time-series change models developed from the research have allowed NIEA to lead inter-governmental department discussion on biodiversity and land use issues. It has also guided the development of an NI habitat biodiversity management strategy. Specifically, the statistically structured field and analytical methods developed by the research for assessing terrestrial habitats at the regional landscape-scale have been adopted by NIEA as key to reporting on the biodiversity outcomes of implementing the European Community conservation Habitats Directive.
The research has provided a common ecological framework within which NIEA, DARD (including Forest Service) and non-government organisations (Ulster Wildlife Trust and Northern Ireland Environment Link) have been able to discuss and agree on biodiversity and agri-environment management practices in designated statutory conservation sites and the farmed countryside. It has also been key in guiding a NI assessment of the socio-economic value of habitats (ecosystem services).
This case study focuses on the development and usage of self-help material designed to aid people in feeling and performing better. It has achieved impact through raising awareness via mass media and professional outlets. Research informed self-help materials are available for open access via media links, academic organisations, service organisations (NHS), commercial organisations (London Marathon), national governing bodies (Research Councils), and professional bodies (British Association of Sport and Exercise Sciences). An on-line project, run in conjunction with BBC Lab UK, developed and tested self-help interventions with 75,000 users each receiving personalised feedback from former Olympian Michael Johnson.
Research on the environmental safety and toxicity of nanomaterials in fishes has had a global impact across both government and industry contributing to:
(i) Consensus building on biological effects allowing regulatory agencies/governments to make proper decisions on the hazard of nanomaterials to farmed fish and wildlife.
(ii) Critical evaluation of the internationally agreed process of toxicity testing to determine whether the current legislative test methods are fit for purpose and acceptable to the aquaculture industry.
(iii) Identification of national/international research priorities and policies via work with the OECD and the US Government.
(iv) Influencing government policy to support training and information for industry.
The Fault Dynamics Research Group (FDRG) have designed and executed analogue experiments to replicate the 3D/4D geometry of oil and gas exploration targets. The main beneficiaries are the international petroleum industry. The research is "pivotal to British Petroleum's subsurface developments" (R. Humphries BP 2012) in determining the number of multi-million pound wells required to access reserves. FDRG models "changed the way seismic data (was) interpreted" (Chief Scientist, Geoscience Australia 2012) in particular in the NW Australian frontier with "BP Exploration (Alpha)....work program(s) of $600 million" (Chief Scientist, Geoscience Australia 2012).
This case study concerns the impact of Plymouth University research relating to farmed fish diets, which led to changes to EU legislation with respect to two types of ingredients: animal proteins and probiotics. The impact of the reintroduction of certain animal proteins in farmed fish feeds (previously banned to protect human health) and to the authorization of a probiotic as a feed additive, involved industry investment in research, have reduced the environmental impact of farmed fishing, improved competitiveness, enhanced yield and quality and improved fish health and survival.
Work by University of Stirling staff has contributed directly to improved wildlife resource management in the Central African region. Innovative research into the status and trends of key wildlife populations, ecological impacts, resource harvests and trade, drivers of resource use and assessing management success have contributed directly to new thinking on the issue, revisions of laws and policy and to success in attracting foreign aid for management issues. Stirling staff members now advise the Government of Gabon on resource management policies, National Park management and biodiversity issues.
Research and knowledge exchange led by Prof. Jefferies in sustainable urban drainage systems (SUDS) has driven the design and integration of SUDS into urban environments, into urban planning and everyday practice in the UK, Europe and worldwide. This research has contributed to the development of policies and established guidelines that have informed the set-up of operational and monitoring systems and the reduction of a training manual which is impacting widely on the sector (downloaded >40.000 times). Evidence gathered through this research has supported drainage policy nationally and now underpins important parts of urban infrastructure, improving environments and their resilience to flooding.