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The impact of educational research from the Rothschild Centre for Clinical Simulation and Education Research (RCSER) at Imperial College London has progressed from the development and validation of simulators and skill assessment, through to shaping guidelines for training curricula and continued professional development in the NHS and beyond. This body of multidisciplinary research brings together Imperial's contributions in simulation science, skills assessment, performance-shaping factors, educational theory and surgical practice to contribute to national and international healthcare education and policy. The work impacts upon clinical practice at regional, national and international levels, with far-reaching implications for the quality and safety of patient care.
UCL's research has led to changes in patient care for men with prostate cancer, through the implementation of less invasive, image-directed treatment and diagnostic strategies, and clinical trials that use these techniques. The use of medical image registration software to deliver high- intensity ultrasound therapy in a targeted manner has been shown to change the treatment plan in half of the patients participating in a clinical study. New biopsy criteria are now used routinely to classify patient risk at University College Hospital, where, since 2009, clinicians have determined the treatment options for more than 741 prostate cancer patients. The scheme has been adopted, by 15 other hospitals in the UK and internationally, where it has become the recommended standard of care, and has been used to treat more than 1,200 patients.
Effective industrial design and simulation require efficient and versatile computing systems. As a result of research performed by our team experienced in High Performance Computing (HPC), novel software structures and aligned hardware architectures have led to significant benefits to the energy supply industry and to microprocessor manufacturers.
As a result of our research with supercomputing, simulation times for electric field patterns in power components have reduced more than 30-fold, with accurate complex 3-D outputs for an increased range of configurations, thereby enabling our partner company to achieve results not possible with commercial software and to reduce product development costs by $0.5M - $5M p.a.
Our research has been incorporated by Intel into their numerical libraries and now made available to the general public supported by their latest processor architectures. Intel now has a 82% share of processors, according to the November 2013 Top500 list.
RTT (Real Time Tomography) scanning systems for airport baggage are becoming increasingly important due to growing air traffic and greater security concerns. Prior to our research, Rapiscan, a leading producer of baggage scanners, had been unable to make full use of the hardware in their latest generation of scanner prototypes. Our novel theory and image reconstruction algorithms are now a core part of a commercially successful 3D scanner that is significantly faster and more accurate than previous generations. The two models, RTT80 and large RTT110, have been approved by regulatory authorities and have already been field trialled at Manchester Airport and deployed at Seattle airport, with further US$20m orders placed.
The research and impact described herein was flagged in the citation for the UoM's 2013 Queen's Anniversary Prize for Higher and Further Education for its work in imaging techniques to support advanced materials and manufacturing.
Research on medical imaging, undertaken by Kranioti at the University of Edinburgh since 2010, has led to cultural, commercial and practice-based impacts.
i) Collaboration with National Museums Scotland (NMS) on the successful Fascinating Mummies exhibition (2012) involved the construction of an in-depth virtual view of a specific popular exhibit — the Rhind Mummy excavated in 1857 (5.3). The initial exhibition attracted 61k visitors, and provided enhanced public understanding of these important artefacts and material about the virtual view continues to be available online.
ii) Collaboration with the Holoxica company to combine computerised tomography (CT) scanning technology with photonics technology in order to produce an innovative digital hologram product based on the Rhind Mummy's skull giving a true 3D view of the object. This has subsequently been displayed at the Holography Museum at MIT, Cambridge, MA.
Radiologists and police in Scotland have separately sought Kranioti's expertise to improve their understanding of the values of medical imaging technology in cognate fields of forensic anthropology.
The Dermatology Life Quality Index (DLQI) questionnaire is a clinical and research tool, which has fundamentally shifted dermatology from being doctor-centred to patient-centred. Previously, no standard method to quantify the impact of skin disease on patients existed. The DLQI was created by interviewing people with skin disease and made clinically useful through development and validation of score bands. NICE/SIGN require UK dermatologists to use the DLQI when assessing severe psoriasis and hand eczema. DLQI is used in national psoriasis guidelines in 14 countries, is available in 91 language translations, has been used in 678 clinical research studies and generated £881,236 in royalties to Cardiff University.
Research carried out at the University of Southampton has led to the development of a new tool for detecting and managing malnutrition. The Malnutrition Universal Screening Tool (MUST) has been rolled out to more than 80% of hospitals and care homes in England and 98% in Scotland, is part of national health policy in Finland and the Netherlands, and has attracted interest internationally. The National Institute for Health and Clinical Excellence bases its current quality standard for nutritional support in adults on the MUST framework; only two NICE guidelines have saved the NHS more money. MUST has become an integral part of the UK's health policy framework, embedded in routine clinical care and supported by bodies responsible for clinical and care excellence. It is central to learning programmes on managing malnutrition.
Research in machine virtualisation conducted in the Cambridge Computer Laboratory from 1999 onwards provides the basis for much of the present day Cloud.
Xen is a virtual machine monitor that supports execution of multiple guest operating systems consuming little overhead and providing resource isolation. This was prototyped in the Laboratory and led to XenSource, a spin-out company, which was founded in 2005. XenSource was acquired in 2007 by Citrix Systems for US$500M, and products that were launched from December 2007 onwards have had a profound impact throughout the period. Xen is now used on millions of machines around the world, providing deployment flexibility and savings on power. It forms the basis of Citrix XenServer and Amazon's Elastic Cloud 2.
Non-technical aspects of clinicians' performance, including cognitive errors and lack of teamwork, are a common cause of adverse events for patients. A series of studies at the University of Aberdeen identified the non-technical skills of operating theatre staff, and developed behavioural rating systems for their evaluation. The resulting skills frameworks for anaesthetists (ANTS), surgeons (NOTSS) and scrub practitioners (SPLINTS) have been adopted and implemented by these professional groups, across the UK and elsewhere in the world.
The resulting impact has been on healthcare professional standards, guidelines and training. Practitioners have used these research findings and tools in the conduct of their work.