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From 2008-2010, Peter Murray-Rust developed a Chemistry Add-in for Microsoft Office Word, which enables users to insert and modify searchable, semantically rich chemical information within a Microsoft word document and for the data to be stored and manipulated in a semantically rich manner. The Add-in has been downloaded over 400,000 times. It was one of the first projects from Microsoft Research for which a public release under an open source license was obtained. This project demonstrated to a wide audience new semantic approaches to computing in chemistry. Chem4Word has impacted on education, publishing and science in industry and academia.
The spectroscopic observation in the interstellar medium (ISM) of an increasing number of molecules has demonstrated the presence of a rich chemistry, especially in the low temperature (ca. 10 K) environment of dense interstellar clouds. Understanding this chemistry requires the combined efforts of modellers and laboratory scientists. In the 1990's, research at the University of Birmingham pioneered a series of unique measurements in which rate coefficients for reactions were measured at temperatures down to as low as 13 K. These results have made a significant impact on the world leading space agencies (NASA and ESA), who have benefited from this research through gaining a better understanding of interstellar chemistry. Mission priorities and instrument design have been influenced by this improved understanding with three (out of a total of 21) instruments carried by NASA's Rosetta comet-rendezvous mission designed to carry out activities that draw significantly on the Birmingham findings. This demonstrates the impact on the allocation of budgets by these agencies and their scientific aims. The detection of molecules and the study of their formation are now viewed as top priorities, which ultimately impacts on the search for bio-signatures and life elsewhere in the Solar System.
The cost of goods is an especially important issue in developing commercially available agrochemicals, which must be manufactured on a large scale. Richard Compton's research at the University of Oxford has led to a step change in the understanding of heterogeneous reaction mechanisms for liquid — organic solid or liquid — inorganic solid processes involved in large-scale manufacturing processes. Compton's work has had particular impact on optimising the processes used by Syngenta AG in its manufacturing of agrochemicals. Since 2008 the insights gained on inorganic-base dissolution have been of great benefit to Syngenta in its development of scalable robust manufacturing processes, particularly in relation to production of its fungicide Amistar and insecticide Actara, which are two of the world's largest selling products of this type. In 2012 Syngenta achieved total sales of over $ 14 billion, $ 4.8 billion of this from fungicide and insecticide revenues.
University of Nottingham researchers have been at the forefront in promoting and establishing Green Chemistry in developing nations. Working with and influencing colleagues and policymakers in both the UK and Africa, they have increased awareness of the importance of introducing sustainable technologies that meet local communities' needs. As a result, they have invigorated the chemistry teaching curriculum in Ethiopia, placing Green Chemistry at its core, and helped shape the approaches of professional bodies, including the Royal Society of Chemistry, for the benefit of the developing world. This has led to what the British Council has described as "a sense of empowerment and confidence" among Ethiopian chemists.
Super-repellent surfaces created by plasmachemical techniques invented at Durham University have been exploited by P2i as the Ion-mask™ and Adiron™ brands and used to protect the surfaces of millions of products worldwide including: 3 million pairs of footwear (Timberland, Hi- Tec); 8 million mobile phones (Nokia, Motorola, Alcatel); 60% of the world's hearing aids (HLT, GN Resound); 55,000 feet of filter media (Porvair); and 100 million pipette tips (Eppendorf). This has earned P2i industry awards including the 2011 and 2012 International Business Award for "Most Innovative Company in Europe" and the "Global Business Excellence Award" 2012. The combined turnover of P2i since 2008 was ca. £20M, it received external investment of £31.75M and has created 115 new jobs. A DU IP-holding spin-out company, Surface Innovations, was purchased by P2i in 2010, and further applications of DU plasmachemical functionalization were commercialized by Dow Corning Plasma Solutions Ltd and exploited in-period.
Our high profile astronomy research discoveries in areas of public interest have allowed us to substantially increase the engagement of the public with science. Media appearances have led to a philanthropic donation of £200k to promote our science, the most successful public event series ever in Northern Ireland (engaging around 2000 people), a strategic partnership with Ireland's award winning science education centre W5 (reaching 26,000 people), and a 49% increase in applications to physics based degrees from NI students to UK HEIs. In 2008 we set three simple targets to substantially increase the public awareness of science and physics. The first was to increase our presence in the mass media (print, radio, TV, internet) to promote scientific research, and we have regularly reached audiences in excess of 295,000. The second was to increase the numbers of people attending science talks and events. The third was to substantially increase the application rate of school students to study physics and mathematics degrees. Through our outreach and engagement programme we have met, and surpassed, all of these targets. The impact of our research and our public outreach programme is a quantifiable societal change. Substantially more NI school students are now studying physics at third level UK HEIs.
Novel vapour sorption experimental methods for the characterisation of complex particulate materials have been developed in the Department of Chemical Engineering. This research and expertise resulted in the creation of Surface Measurement Systems Limited (SMS), whose Dynamic Vapour Sorption (DVS) and Inverse Gas Chromatography (IGC) instruments are now found in >500 laboratories around the world. They are recognised standard research and development tools in the global pharmaceutical industry (DIN 66138). SMS has contributed >270 man-years of employment and generated £27M of turnover, whilst SMS instruments have generated over £300M of economic value, over the REF period.
The growth and performance of Biofocus Galapagos Argenta (BGA) and Pulmagen Therapeutics (PT) are underpinned by research from the Imperial-based TeknoMed project that started in 1997. BGA was formed in 2010 through the acquisition of Argenta Discovery (AD) by Biofocus Galapagos for €16.5 million and is one of the world's largest drug discovery service organisations with 390 plus employees and turnover of €135 million [section 5, A]. PT was formed as a separate company to own the complete AD drug pipeline. It develops new medicines to treat asthma, cystic fibrosis and allergic diseases. In 2011 BGA signed agreements with PT for an initial £6million fee and with Genentech for £21.5million.
University of Huddersfield research in physical organic chemistry has delivered economic, industrial and societal benefits. It has led to process improvements in chemical manufacturing, most notably in the optimisation of the synthesis of antisense oligonucleotides and in the use of liquid ammonia as a solvent. It has also led to the development of new inhibitors of bacterial β-lactamases for use as antibacterials. The research team's expertise has been reflected in the success of IPOS (Innovative Physical Organic Solutions), a unit established in 2006 to carry out research in process and other areas of chemistry for the chemical industry. IPOS expanded significantly from 2009 to 2013 and has now collaborated with more than 150 companies, many of them based in Yorkshire/Humberside where regeneration is critically dependent on the success of new, non-traditional, high-technology firms and industries. Through these collaborative projects, IPOS has contributed to the growth and prosperity of both regional and national industry.
The School of Chemistry has a long track record of pioneering and innovative outreach activities aimed at stimulating public interest and understanding in chemistry research and its societal impact. During the period 2008-2013 it successfully communicated to a wide-ranging audience the significance of a series of "firsts" in the areas of nanoscience and materials for energy applications. Using YouTube, Royal Society Summer Science Exhibitions, roadshows and science festivals, this award-winning approach has engaged hundreds of thousands through digital media and thousands more face-to-face, raising public awareness, inspiring interest in science and delivering educational benefits for students and teachers alike.