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This University of Liverpool (UoL) research programme has provided the first international guidance on pregnancy dosage regimes for the drug misoprostol. Although commonly used, its use in pregnancy is off-label. This has led to a wide variety of different dosage regimens. Professors Weeks, Alfirevic and Neilson (all UoL) have been at the forefront of research into its correct use since 1998. In 2007 they initiated a WHO expert conference to conduct dosage reviews, thus establishing an international consensus. These regimens were adopted by the International Federation of Gynecology and Obstetrics (FIGO) in 2009, and updated in 2012. Examples of resulting guidelines with social marketing are provided.
Impact: Health and welfare; healthcare guidelines on elective induction of labour. The research showed that elective induction at time points from 37 weeks' gestation progressively reduces perinatal mortality. UK guidelines now recommend routine induction at 39 weeks in mothers >40 years of age.
Significance: Implementation of the guidelines for mothers >40 years of age is estimated to prevent the stillbirth of 17 babies per year in the UK.
Beneficiaries: Pregnant women, policy makers and healthcare providers.
Attribution: The work was led by Jane Norman with Sarah Stock at UoE, in collaboration with NHS Information Scotland.
Reach: UK, Europe, North America. Applies to all pregnant women, especially those over 40 years of age.
Two books and review/research articles in Italian have disseminated the findings from the underpinning research on creating false autobiographical memories and the dangers of inadequate interviewing techniques. This work has critically increased awareness in the Italian legal system amongst both barristers and judges, to the point of shaping the practice of interviewing witnesses in that country. It has also informed all verdicts on child sexual abuse by the Supreme Court of Cassation.
Research has linked employee wellbeing to employee motivation and engagement, which can in turn drive increases in productivity and improved levels of product/service delivery. This case study illustrates how academic research and enterprise-based activity, through a university spinout company, has helped to create a significant positive impact on promoting and improving employee wellbeing. This has been achieved across a variety of national and international organisations, including several high profile private and public organisations, involving over 50,000 employees across Europe. This has resulted in a number of positive outcomes such as national and international awards in the area of HR as well as increased employee engagement and reduced employee absenteeism.
Work by University of Stirling staff has contributed directly to improved wildlife resource management in the Central African region. Innovative research into the status and trends of key wildlife populations, ecological impacts, resource harvests and trade, drivers of resource use and assessing management success have contributed directly to new thinking on the issue, revisions of laws and policy and to success in attracting foreign aid for management issues. Stirling staff members now advise the Government of Gabon on resource management policies, National Park management and biodiversity issues.
Research on the environmental safety and toxicity of nanomaterials in fishes has had a global impact across both government and industry contributing to:
(i) Consensus building on biological effects allowing regulatory agencies/governments to make proper decisions on the hazard of nanomaterials to farmed fish and wildlife.
(ii) Critical evaluation of the internationally agreed process of toxicity testing to determine whether the current legislative test methods are fit for purpose and acceptable to the aquaculture industry.
(iii) Identification of national/international research priorities and policies via work with the OECD and the US Government.
(iv) Influencing government policy to support training and information for industry.
This case study illustrates the development of novel research materials designed to improve quality of life and performance in different populations. Impact has been achieved through the use of research findings in professional practice, formulation of health-related policies and in the development of new indicators of health and well-being. RCSEP research has been used by international and national health-service organisations (e.g., European League Against Rheumatism, Evidence NHS), industrial establishments (e.g., ArtEZ Conservatoire, Netherlands; Royal Ballet), national governing bodies (British Heart Foundation), and professional bodies (e.g., Dance UK, International Association of Dance Medicine & Science).
This case study focuses on the development and usage of self-help material designed to aid people in feeling and performing better. It has achieved impact through raising awareness via mass media and professional outlets. Research informed self-help materials are available for open access via media links, academic organisations, service organisations (NHS), commercial organisations (London Marathon), national governing bodies (Research Councils), and professional bodies (British Association of Sport and Exercise Sciences). An on-line project, run in conjunction with BBC Lab UK, developed and tested self-help interventions with 75,000 users each receiving personalised feedback from former Olympian Michael Johnson.
The thesis of this case study is that a demonstration project, encompassing an organisational change, utilising the principles that underpinned a Department of Health (1993) policy for maternity care, has been influential in corroborating and establishing a philosophy for maternity services in industrialised countries within the 21st century.
The project provided an evidence-based approach to standards and quality of midwifery care. It demonstrates outcomes influencing national and international guidelines and policies for maternity practice. As a result, current midwifery guidelines for the UK and other countries, such as Australia, New Zealand, The Netherlands, Sweden and Canada, include elements of continuity of care/r (including one-to-one care and case loading) informed choice for women and evidence-based practice.
Pioneering research at the University of Chichester lead by Professor Harris provided in 2006 first evidence on the effectiveness of beta-alanine supplementation in augmenting carnosine content in human skeletal muscle. Subsequent studies demonstrated the performance-enhancing effect of beta-alanine supplementation, particularly in high-intensity exercise. The research was exploited by a US company through a number of worldwide patents based on Harris' work achieving sales and license revenues of $4.8M in 2013 fiscal year alone. Beta-alanine supplementation has emerged as a legal means to enhance performance taken up at amateur and elite level sport worldwide; it is having global impact on the sports nutrition industry.