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Research at Manchester has led to the development of a new class of high performance magnesium alloys based on the addition of rare-earth alloying elements. The new alloys combine low density and the highest strength of any magnesium alloy. Used to substitute for aluminium in aerospace and automotive they produce weight savings of 35% improving performance and reducing fuel consumption. Commercialisation of these alloys by Magnesium Elektron (ME), the international leader in magnesium alloy development, contributes over $20m per annum to company revenue. This includes development of the first commercial product available for bioresorbable magnesium implants, SynermagTM, launched in 2012.
The development of the chemistry of Selectfluor® (F-TEDA-BF4) has resulted in this Manchester-discovered reagent becoming the world's most widely used commercial electrophilic fluorinating agent to introduce fluorine into a range of pharmaceuticals and agrochemicals. Annual worldwide production is ca. 25 tonnes and sales estimated to be US$7.5m. Selectfluor is used in the synthesis of fluticasone, a fluorinated corticosteroid which is the active ingredient in GSK's Advair ($3.6bn sales in 2010) used in the treatment of asthma and chronic obstructive pulmonary disease symptoms; top 25 selling drugs Flixonase, Flixotide, Flonase, Flovent HFA and Advair Diskus which had total sales of over $17bn between 2009-2012.
The field of conceptual chemical process design as practiced industrially has been influenced significantly by the outputs from the Centre for Process Integration (CPI) at Manchester. Process Integration Ltd (PIL) was spun-out from Manchester and currently employs over 50 staff globally, who have conducted projects that have resulted in annual cost savings of hundreds of millions of US dollars. The application of CPI technology has led to significant reductions in both energy costs and emissions of greenhouse gases. Since 2008 ca. US$350m of savings have been realized through the exploitation of CPI technology with US$1.4m generated from software sales.
For decades Jodrell Bank has been a world-leader in both radio astronomy research and public engagement with science. The Lovell Telescope in particular, whilst still remaining one of the world's foremost active research instruments, has become an icon for UK science and engineering. In this case study we show how Jodrell Bank research has had a significant impact on society, culture and creativity, including economic impacts of tourism, educational impacts from engagement with schools, and cultural and creative impacts in television, music and the arts. Our approach to delivering this impact is varied and wide-ranging but a key vehicle is the Jodrell Bank Discovery Centre. The Centre has a significant impact on the regional economy and has attracted 496,000 visitors (including 43,000 school pupils) to engage with our research over the REF period Jan 2008-Jul 2013.
WHO estimates that 600 million school-age children need deworming treatment and preventive intervention.
The University of Manchester (UoM) Immunology Group delivered an educational programme on the immune response and biology of parasitic worm infections in areas where worm infections are most prevalent, including Uganda and Pakistan, and with UK immigrant communities.
International benefits include health worker and educator training, which is critical for improving the understanding of worm infection and distribution of health education messages to endemic communities. Nationwide engagement activities provided immigrant communities and school pupils with improved awareness of global health issues and a greater understanding of immunology, and have inspired some participants to pursue careers in science.
The lasting impact of Professor Prag's work on facial reconstruction is that it has become a vital tool for archaeologists, helping them to understand the past better. Facial reconstruction now plays a major role in many museum exhibitions around the world and the techniques developed in Manchester have increased public interest in past civilizations. An important aspect in the reconstruction process is the ability to work across disciplines to produce a complete picture. Manchester has pioneered this method of collaborative working with some ground-breaking results. The facial recognition methods established by Professor Prag continue to impact on archaeological and museum practices around the world to bring history truly to life.
Functions of matrices underpin many of the fundamental algorithms used in the finance, engineering and pharmaceutical industries. Our research has provided the state of the art algorithms for computing the most common matrix functions. The algorithms have been implemented commercially in MATLAB (with almost 2 million users) and the Numerical Algorithms Group (NAG) Ltd Library; as well as in open source packages such as R and Eigen. Software companies have enjoyed direct impact through improved products and increased revenues, whilst the greater indirect impact is for the users of the software, leading to acceleration in the pace of science and engineering worldwide.
Research at the University of Manchester (UoM) has changed the landscape of medical care and research in fungal infections internationally. The impacts include: the world's first commercialised molecular diagnostic products for aspergillosis and Pneumocystis pneumonia (£10m investment); pivotal contributions to the preclinical development (£35m investment), clinical developments and registrations of 3 new antifungals with combined market share of ~$2 billion; one (voriconazole, 2012 sales >$750m worldwide) now first line therapy for invasive aspergillosis with improved survival of 15-20%; and internationally validated methods to detect azole resistance in Aspergillus (an emerging problem partly related to environmental spraying of azole fungicides for crop protection).
Research on ester liquids (ELs) has proved they can be used in high-voltage (HV) transformers, bringing economic and safety advantages to the power industry and environmental benefits to society. Impact includes revisions to National Grid's oil policy recommending ester-filled HV transformers for use in London and the design and operation of the first 132kV "green" transformer (valued between £1m and £2m). The research has led directly to the creation of two international standards for professionals in global power utilities specifying the use of ELs in transformers. These developments have contributed directly to Manchester SME M&I Materials increasing sales from £15m (2008) to £29m (2012).
This University of Manchester research underpins UK industry's global position in millimetre- wave imaging and ultra-high-precision sensing. These are key technologies in a range of industrial, medical and consumer electronics applications. The devices and methods developed by the research team are now used by a range of companies leading to economic impacts for the UK in strong export markets. In this case study we provide examples of impacts that support commercial sales in excess of £300m by UK SME and FTSE-listed companies in three sectors: automotive radar (e2v), terahertz imaging (TeraView), and linear encoders (Renishaw PLC).