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This case study focuses on the development and usage of self-help material designed to aid people in feeling and performing better. It has achieved impact through raising awareness via mass media and professional outlets. Research informed self-help materials are available for open access via media links, academic organisations, service organisations (NHS), commercial organisations (London Marathon), national governing bodies (Research Councils), and professional bodies (British Association of Sport and Exercise Sciences). An on-line project, run in conjunction with BBC Lab UK, developed and tested self-help interventions with 75,000 users each receiving personalised feedback from former Olympian Michael Johnson.
Research on the environmental safety and toxicity of nanomaterials in fishes has had a global impact across both government and industry contributing to:
(i) Consensus building on biological effects allowing regulatory agencies/governments to make proper decisions on the hazard of nanomaterials to farmed fish and wildlife.
(ii) Critical evaluation of the internationally agreed process of toxicity testing to determine whether the current legislative test methods are fit for purpose and acceptable to the aquaculture industry.
(iii) Identification of national/international research priorities and policies via work with the OECD and the US Government.
(iv) Influencing government policy to support training and information for industry.
Working with TMO Renewables Ltd, work in Dr Leak's laboratory at Imperial College demonstrated that thermophilic bacteria of the genus Geobacillus could use a novel (i.e. non-textbook) route to produce ethanol. TMO used this information to develop strains that produced ethanol in commercially useful quantities from lignocellulose breakdown products. This allowed them to: (i) compete for and win a major contract ($500M over 20 years) with Fiberight in the USA in 2010, to turn fermentable components of municipal solid waste into biofuel, (ii) enter into partnership agreements with the China National Offshore Oil Corporation and the China National Cereals, Oils and Foodstuffs Corporation in 2011, and (iii) enter into agreements in 2012 and 2013 with Usina Santa Maria Cerquilho to build a bioethanol production facility in Brazil. The most recent agreement with Brazil will create more than 150 new jobs in the UK. At the end of 2011, TMO Renewables reported a net worth of almost £11million.
Two books and review/research articles in Italian have disseminated the findings from the underpinning research on creating false autobiographical memories and the dangers of inadequate interviewing techniques. This work has critically increased awareness in the Italian legal system amongst both barristers and judges, to the point of shaping the practice of interviewing witnesses in that country. It has also informed all verdicts on child sexual abuse by the Supreme Court of Cassation.
Mathematically-based image processing techniques developed at the University of Cambridge have helped bring about a revolution in the ability to extract quantitative measurements from laboratory experiments in fluids. Techniques and software tools developed from this research and incorporated into commercial software are now used in engineering, physics and mathematics research laboratories around the world on projects ranging from fundamental research to ones with strong industrial connections.
This case study concerns the impact of Plymouth University research relating to farmed fish diets, which led to changes to EU legislation with respect to two types of ingredients: animal proteins and probiotics. The impact of the reintroduction of certain animal proteins in farmed fish feeds (previously banned to protect human health) and to the authorization of a probiotic as a feed additive, involved industry investment in research, have reduced the environmental impact of farmed fishing, improved competitiveness, enhanced yield and quality and improved fish health and survival.
Knowledge of the three-dimensional structures of macromolecules is a prerequisite for understanding their function at the atomic level, an essential component of modern drug development. Most structures are determined by X-ray crystallography: the majority using molecular replacement (MR, which exploits known structures of related proteins), and about half of the remainder using single-wavelength anomalous diffraction (SAD). The Phaser crystallographic software, developed by Read and colleagues, implements powerful new likelihood-based methods for MR and SAD phasing and has made a large impact, accelerating over the period 2008-2013. At the pharma giant, AstraZeneca, Phaser is considered the "tool of choice" for solving structures by MR.
Essex research identified a novel bioprocessing matrix which has since been developed into commercial products and recently launched into external markets by Porvair Filtration Group Ltd. The discovery involved the chemical modification of sintered thermoplastic materials in order to attach biological molecules, so conferring highly specific functionalised properties to an otherwise inert base material. This enabled a new approach for protein immobilisation, having technical and practical advantages over existing processes. As a direct result, Porvair has adopted a new technology and invested £900k in R&D over eight years. Essex research has supported a change in business strategy, enabling entry into new markets, which has in turn both safeguarded and created jobs at Porvair.
Over 25 years, research by Hendry and Stevenson has explored the specific challenges faced by Make-to-Order (MTO) manufacturing companies and developed a novel Workload Control (WLC) approach, which has been most notably implemented in PDS Engineering. This led to significant increases in successful bids and reductions in lead times for PDS, with a knock on effect through their supply chain that includes large aerospace companies like Rolls-Royce. Publication of this stream of research led to international collaborations including in the Netherlands and Belgium, where an EU project involving 10 firms and further consultancy work has also led to reductions in lead times, typically of over 50%. The WLC approach is now ready for commercialisation in the UK.
Research led by Dr Brian Singer on techniques for analysing artists' materials has helped museum and gallery conservators develop treatments through a sound knowledge of the materials present. Publications by conservators (2008-11) reference the research and, in relation to high-profile works by Munch, cite changes in practice that have enhanced the continuing availability of this artist's oeuvre. The same research has supported the estate of Francis Bacon, assisting its authentication committee to define authenticity and date of unattributed works for inclusion in Bacon's catalogue raisonné. Singer's research and methods have ultimately benefited the wider public, ensuring engagement with 20th Century art in the long term.