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As a result of research on moisture sensing, Professor Patricia Connolly developed and successfully clinically trialled a disposable, sterile, moisture sensor which enabled real-time measurement of the moisture level in a wound without disturbing the dressing. Ohmedics Ltd was spun out in 2009 to market the disposable sensor and associated hand-held meter. The system, known as WoundSense™, gained the CE mark in 2010. The device is available commercially and is in use in hospitals in Saudi Arabia and Qatar, is starting to penetrate international markets, and had first sales to the NHS in the UK in 2012. The system is being piloted for use with remote monitoring `telehealth' technology. The British military currently (July 2013) have the system in clinical trial for monitoring of complex trauma wounds. The creation of Ohmedics has given specialist employment to 6 people in the company and helps support another 4 skilled jobs at UK contract manufacturers.
Research by the University of Huddersfield has helped shape policy and practice in the field of surgical site infection (SSI) and wound management. It has contributed to best practice guidance and helped to raise practitioner, industry and public awareness of the importance of effective clinical interventions in infection prevention, tissue viability and wound care. These efforts, recognised by numerous awards, have been supported by significant industry engagement and the successful development and use of on-line tools to share best practice, promote evidence-based care and highlight the value of an inter-disciplinary approach to the problem of SSI.
Impact: altered business practice / new business venture created
Research into biophysical detection methods undertaken within PHYESTA has resulted in a Gothenburg-based multi-national, Mölnlycke Health Care, establishing a Scottish subsidiary (MHC Scotland) to exploit a commercial (exclusive license) partnership involving PHYESTA and Scottish Enterprise. This represents (i) creation of a new business sector for the company, and (ii) adoption of a new technology into its portfolio.
Significance: Mölnlycke Health Care has used its access to PHYESTA's IP portfolio, via license arrangements, as the primary vehicle for creating a new business venture enabling its entry into the diagnostics market for the first time.
Reach: Mölnlycke Health Care is a leading innovator in infection control in hospitals with employees in 30 countries worldwide. Its entry into the diagnostics market has implications for the entire company.
Beneficiaries: Impact in 2011-2013 pertains primarily to Mölnlycke Health Care and to the Scottish economy.
Attribution: This work was led by Professor Jason Crain, in collaboration with Professor Andrew Mount (Chemistry), Professor Peter Ghazal (Medicine), and Professor Anthony Walton (Engineering).
Research co-led by Prof Roz Anderson, in collaboration with a multi-disciplinary team, resulted in a new chromogenic substrate for the rapid detection and specific identification of the bacterial pathogen, Pseudomonas aeruginosa, a `super-bug' that threatens many thousands of hospital patients annually, leading to poor clinical outcome and increased risk of mortality.
bioMérieux adopted the technology for a new product, ChromID® P. aeruginosa, for commercial realisation as a clinical microbiology test; it was launched in the EU, USA and Australia, supporting the company's commercial position as leaders in this field. This test has enhanced the care of patients, through more rapid detection of P. aeruginosa and earlier informed clinical decision- making.
Research from the Department of Materials Science and Engineering led to healthcare impact through treatment of burns patients and those with chronic non-healing wounds using the culture and expansion of the patient's own skin cells. This impact was achieved by establishing a product, MySkin®, as the UK's first and only commercially available complete service for the culture and delivery of patient's skin cells. It is now used in 11 out of the UK's 12 major burns units for patients in danger of death from extensive burns. MySkin® benefits patients, clinicians and nurses and was Biomedical Product of the Year in 2008 (see Sky News video (2008) on www.Ilika.com).
Adults with epidermolysis bullosa have extensive chronic wounds that seriously compromise their quality of life. Research at King's College London (KCL) has led to the development and commercialization of an innovative range of dressing retention garments, Skinnies WEB™, which radically improve patient experience and significantly reduce costs. KCL work has also generated a range of novel methodologies for research including a validated n-of-1 design for proof of concept tests, a validated model for engaging users in the design and development of medical devices and the TELER clinical notemaking system for wound care, which has been adopted internationally. This work has generated new business opportunities (product lines and roll-outs) for four UK companies.
Bristol University's School of Veterinary Sciences, a global leader in feline medicine, was the first UK centre to develop and commercially offer polymerase chain reaction (PCR) and quantitative (q) PCR assays to detect a range of feline infectious and genetic diseases. Since 2008 there has been a dramatic increase in the number of qPCR tests performed, with over 35,000 tests carried out between 2008 and 2013. The results of genetic testing have informed breeding programmes and resulted in a reduced prevalence of genetic disorders such as polycystic kidney disease (PKD). The results of testing for infectious diseases have informed diagnosis and treatment modalities and, together with the genetic testing, have contributed to significant improvements in feline health and welfare. This work has also generated commercial income in excess of £1.7M, which has been used to further research into feline infectious and genetic diseases.
Impact on health and public policy: The World Health Organisation (WHO) now recommends that children under 6 years, who had hitherto been excluded from drug treatment, should be included in schistosome control programmes, following research by UoE that reversed previous assumptions about schistosomiasis infection rates in pre-school children (1-5 year olds) and demonstrated the safety and efficacy of Praziquantel (PZQ) treatment in this age group.
Beneficiaries: WHO policy change affects children under the age of 6 years in countries affected by schistosomiasis (up to 10 million children). 350,000 pre-school children in Zimbabwe have so far been treated with PZQ, with a further 1.2 million already identified by the Ministry of Health for inclusion in the next round of MDA to start in October 2013
Significance and Reach: 5-10 million pre-school children in Africa (WHO estimates) now merit treatment. Urogenital schistosomiasis affects more than 100 million people in Africa; in affected populations, children carry the heaviest burden of the disease. Following the recommendations from the WHO on preschool children, 4 countries (Niger, Malawi, Uganda and Zimbabwe) have so far included pre-school children in their schistosome control policies with Zimbabwe currently implementing this.
Attribution: Dr Francisca Mutapi led the research at UoE establishing the evidence base for the safety and efficacy of PZQ. The study was collaborative with UoE leading the research and conducting the laboratory studies, while collaborators at the University of Zimbabwe and National Institutes of Health Research in Zimbabwe organised the fieldwork.
The work of Cardiff University's Wound Healing Research Unit revealed a need for, and led the development of, a disease-specific Health-related Quality of Life (QoL) instrument; the Cardiff Wound Impact Schedule (CWIS). CWIS is able to quantify in a psychometrically sound manner the impact of chronic non-healing wounds upon a patient's QoL. The tool, a first of its type, is accurate and sensitive to changes in the healing status of chronic wounds, particularly those of the lower limb. CWIS has been adopted internationally advantaging QoL assessments in both commercial and practice settings to yield economic and practice impacts as well as direct patient benefits.