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Durham has a long-standing record of research into improving the resistance of crop plants towards pests, which includes pioneering work on genetic engineering of plants for insect resistance. The CpTI gene developed in Durham for enhancing insect resistance in transgenic crops has had a major impact on Chinese agriculture, due to the widespread deployment of GM cotton containing genes encoding Bacillus thuringiensis (Bt) toxin and CpTI. The SGK 321 transgenic cotton line was approved for commercial growing in China in 1999, and by the current REF period Bt/CpTI cotton was grown on approximately 0.5 million hectares of land, representing approximately 15% of the total transgenic cotton grown (which in turn represented 67% of total cotton production). The economic value of Bt/CpTI cotton is estimated as approx. £600 million per year.
Genetically engineered plants are increasingly used to over-express foreign genes, including those for pharmaceutically valuable polypeptides. However, expression of transgenes is repressed via RNAi, a system that probably evolved to combat viral pathogens. In response, viruses themselves encode a "silencing suppressor protein" that counteracts this defence response. This was discovered by David Baulcombe and colleagues at the Sainsbury Laboratory at UEA, who exploited this phenomenon by introducing the suppressor gene into plants and improving them as hosts for transgene expression. RNAi Suppression Technology was patented worldwide and licensed for fees >£500k to several companies, including Medicago, that use it to generate plants that effectively produce pharmaceuticals.
Cranfield's work on ethylene supplemented storage is now exploited in the supply chains to major supermarkets in the UK, including Waitrose and Tesco, reducing waste and avoiding volatility in supply for fresh food products such as onions and potatoes. By prolonging storage life by up to six weeks it is also having a positive impact on the UK's self-sufficiency in these products, displacing imports from overseas.
Complementary work has also led to commercial ethylene scrubbing technologies for packaging, which typically save around 50% of in-store waste and add two days to the product life for a range of fruit and vegetables. Such packing is now in use in most mainstream UK supermarkets, and in the USA where it has created a new export market for the manufacturer.
Carotenoids (e.g. β-carotene, provitamin A) are antioxidants which are essential in the human diet and which reduce the onset of chronic diseases. Research in the unit on the carotenoid pathway has provided the tools and strategies to deliver foods with increased levels of nutritional carotenoids. This has led to the production of novel food supplements and to Golden Rice (GR), a humanitarian product aimed at alleviating Vitamin A deficiency in the developing world. Field and intervention trials have shown that GR is effective and its production feasible. The research has led to beneficial impacts on health and welfare, international development, commerce, public understanding and education.
Research over the last 20 years by Jane Nicklin (née Faull) and her research group has established expertise in fungi, which has led to impacts in three areas: impacts on the licensing of commercial products for the control of insect pests which affect food crops, which have led to a new product being licensed in the US to the benefit of vine growers; impacts on heritage conservation, where the work has benefitted English Heritage, the National Trust and many other conservation groups; and impacts on public awareness and media engagement with science, in particular through her work with Channel 4's How Clean is your House? in 2009.
Research and knowledge dissemination led by Greenwich on biological pesticides has made a major contribution to the introduction of novel safe commercial pesticides based on insect viruses to help farmers overcome the problems of chemical resistance in major crop pests in Asia and Africa. Research at Greenwich identified effective virus strains, methods of production and formulation which were then developed and evaluated with in country research collaborators before being transferred to local SMEs to start up production in India, Thailand, Kenya and Tanzania. Greenwich advised governments on adopting suitable regulation to support the registration and sale of these novel pesticides.
Impact: EaStCHEM spin out Albachem (1994), subsequently incorporated into the Almac group, enabling the latter company to become a world leader in the provision of chemically synthesised proteins.
Significance: Chemical synthesis is competitive with recombinant methods for commercial production of the therapeutic polypeptides that represent ~50% of drugs in big pharma pipelines and have a market value in 2008 of over $13B. The value attributable to Ramage's methods for polypeptide syntheses over the REF period is estimated at approximately £6M.
Beneficiaries: Drug manufacturers, contract research organisations, patients, clinicians.
Research: Studies (1993-6) led by Ramage (at the University of Edinburgh) on new methods for high-yield total syntheses and purification of long polypeptides.
Reach: Almac's protein-manufacturing team remains in the UK with 24 staff members. The Almac Group, headquartered in N. Ireland, has 3300 employees globally (1300 outside UK) and sells to 600 companies worldwide.
Based on innovative technology invented and developed through research at the University of Southampton, sustainable pest control products by spinout company Exosect are being employed around the world to preserve the global food supply. Since 2008 its bio-control products have been newly adopted in diverse situations: by Sainsbury's in response to consumer pressure to reduce chemicals in food; by Bayer CropScience, who bought rights, in a multimillion pound deal, to a product for the protection of bee populations; by English Heritage to preserve the UK's cultural heritage. The technology has inspired a US$1m Gates Foundation grant for poverty reduction efforts in sub-Saharan Africa and raised awareness among conventional pesticide manufacturers of the environmental and economic benefits of bio-control solutions.
Reliable seed performance is the cornerstone of crop establishment, an important trait that determines the cost and resource efficiency of crop production. In practice, seed performance varies, and this creates a substantial global problem for seed producers and farmers. From 1980 until the present time, Finch-Savage and Rowse have provided knowledge, patented techniques and genetic backgrounds from their research programmes to enhance the performance of seeds in crop production. Seed production businesses worldwide use and continue to adopt these techniques. These include both national (e.g. Elsoms Seeds, UK; Seed Enhancements, New Zealand) and global (e.g. Syngenta and Bayer) companies. Therefore, the work of Finch-Savage and Rowse has had, and continues to have, a direct impact on food security, sustainable crop production and the profitability of farming and seed production businesses.
Bio Nano Consulting (http://www.bio-nano-consulting.com) was established as an operating business in 2007 through a joint venture between Imperial College London and UCL, whose formation was underpinned by research produced by Professor Tony Cass's group at Imperial. The company is the first consultancy in Europe to focus on the increasingly important intersection between bio- and nanotechnology, and it facilitates the development and commercialisation of new biomedical and nanotechnology-based techniques. Since its start-up, the company has attracted numerous clients across the aerospace and diagnostics sectors, including Lockheed-Martin and [text removed for publication]. The company's activities have generated £6M worth of revenue and it has a growing portfolio. The company, which is based in London, currently has 8 full time employees.