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Novel bioluminescent bacterial biosensors developed at UWE, Bristol, and commercialised by Randox, have been used by a range of companies to demonstrate effectiveness of drugs and decontamination procedures. This has improved development processes at companies including Clavis Pharma, Purest Solutions and Dycem, leading to new manufacturing processes and quality control test methods. The biosensors are used in novel applications to give pharmacodynamic data on effectiveness of drugs and real time in-situ demonstration of effectiveness of decontamination processes. These biosensors, pioneered and developed by Vyv Salisbury's group, have been commercially adopted and used for evaluation by at least six collaborating companies.
Karl Gerth's work on the role of Chinese consumers in the global economy, and on ways in which Chinese consumerism may create more environmental and policy problems than it solves, has had a significant influence on business leaders seeking to position themselves in the Chinese market, as well as on public discourse around the `rise of China'. Gerth has extended the range and quality of the evidence on the interconnected and wide-ranging ramifications of the shift within China toward a market economy over the past thirty years, and has improved understanding of this phenomenon in ways which have enabled British business to compete more effectively in China.
Research in materials modelling by the Computational Science and Engineering Group (CSEG) is helping aerospace, defence and transport companies design advanced materials and new manufacturing processes. From lightweight components like aeroengine turbine blades to the control of magnetic fields to stabilise the next generation of International Space Station levitation experiments, CSEG is supporting innovations which have:
In the assessment period, CSEG collaborated closely with leading industries in steel-making (ArcelorMittal, Corus), primary aluminium (Dubal, Rusal, Norsk-Hydro, SAMI) and lightweight structural materials for transport and aerospace (European Space Agency, Rolls-Royce).
Alternatives to acute admission in mental health are crucial, not least because of the high cost of inpatient care. We have carried out a major research programme that includes the only randomised controlled evaluation of crisis resolution teams and the only major UK study of crisis houses, which are community-based, residential alternatives to hospital admission. This programme demonstrated the efficacy of community treatment and has significantly influenced decision making at a local and national policy level, including commissioning guidance and three sets of NICE guidelines. This has contributed to changes in the way acute services for severely mentally ill adults are configured in the NHS, and internationally.
Abdominal aortic aneurysm (AAA) is a major cause of death in older men, in the UK and elsewhere. A large UK trial led by the University of Cambridge evaluated the long-term benefits of ultrasound screening for AAA in men aged 65-74 years. This provided the basis for the introduction of a UK national AAA screening programme in men aged 65; this was announced in 2008, initiated in 2009, and achieved full coverage of England in 2013. Similar screening has started in Sweden, New Zealand and in parts of Italy, and is being actively discussed in Denmark, Norway and Finland.
The primary impact is AmbieSense Ltd., a start-up that has had up to 8 employees/consultants. The Company pioneered ambient, context-aware mobile applications and has been able to maintain its technological edge throughout. Secondary impact is through products developed and used by companies including Lonely Planet, Oslo Airport. AmbieSense Ltd. products and services have wide reach and social impact: Tourist trails; outdoor museums; educational historic trails. Customers include public sector: Aberdeen City Council. Benefits are a quality content experience delivered in a context-sensitive manner (social/economic). The significance is: information-rich touristic physical space; an enriching educational experience, connecting pupils with environments. Other technologies have also been built on the AmbieSense platform and patents have cited the underpinning work, demonstrating impact on professional services.
This case study demonstrates that the Transitional Justice Institute (TJI) peace process research has substantially impacted on key stakeholders in multiple conflicted and post-conflict states. Impacts include developing sustained relationships with public officials to inform policymaking, making recommendations for legal changes, capacity building with local non-governmental organisations (NGOs) on peace process issues and addressing conflict-related abuses, informing public debate, and raising awareness of international and comparative legal standards among local judiciaries subsequently applied in their work. Impacts have benefited a range of users and contributed to growing sensitivity to victims' needs in conflict resolution.
The decision about whether to fund new health care interventions is increasingly being informed by evidence of cost-effectiveness in terms of the cost per Quality Adjusted Life Years (QALY). The SF-6D health index is widely used internationally for calculating QALYs from patient reported health outcomes collected in clinical trials and other surveys. It contributes to health system efficiency from being used by health technology agencies around the world (including Australia, Canada, England, Scotland, Ireland and Norway) to calculate QALYs to facilitate decisions about the most efficient use of limited health care resources. The SF-6D is freely available to non-commercial bodies, including researchers and policy makers. Commercial benefits come from the licensing of the measure to pharmaceutical companies, health insurers and others to assess the cost-effectiveness of their products with 460 licenses being sold since 2008. A further 521 licenses are distributed on a non-commercial basis to academic researchers, public sector and charitable organisations.
Research led by Dr Holmes has identified a novel variant of methicillin-resistant Staphylococcus aureus (MRSA) in livestock. This represents a previously unidentified reservoir of infection which has had impact on the epidemiology of MRSA and its management. This research also impacts on antibiotic use in agriculture and its role in the emergence of antibiotic resistance. As a consequence of these research findings commercial tests and testing protocols have been developed to detect the new MRSA variant, which are now used widely in clinical settings throughout Europe. The discovery has also been used to inform policy decisions at a governmental level in the USA and Europe.
Agent-based computing is a new paradigm for building complex socio-technical systems composed of many interacting intelligent and autonomous components. New co-ordination and negotiation algorithms developed at the University of Southampton, have provided new methods for managing such interactions in a flexible manner. This study focuses on their applications in two new start-up companies (Aerogility and Aroxo) in the defence, aerospace and civil contingency sectors (e.g. BAE Systems, Ministry of Defence and Hampshire County Council) in helping the GB Sailing Team to success at the 2012 Olympics, and in monitoring the environment for effects of climate change.