Language impairment is common in children and, without effective early
intervention, presents a risk for educational, social and emotional
disturbance. The team used their considerable experience in child language
research to produce a novel assessment of child language development — The
Reynell Developmental Language Scales 3 (RDLS3) — the first test of child
language development to be standardised in the U.K. to assess both
understanding and production of language in young children. Use of the
test has improved language assessment and diagnosis for children with
language impairments and, as such, has enabled health and education
professionals to target therapy and monitor the effectiveness of
interventions to improve child language development. The test has been
widely used in the U.K. and is now also being used widely internationally.
Recent research by the team has informed a revised version of the test —
The New Reynell Developmental Language Scales (NRDLS). Sales figures of
the RDLS3 and the commissioning of the NRDLS are testament to its
outstanding reputation and enduring legacy worldwide.
Trachoma, caused by ocular infection with Chlamydia trachomatis,
is the leading infectious cause of blindness. Research by Professors David
Mabey and Robin Bailey, LSHTM, has shown that a single oral dose of
azithromycin is an effective, feasible mass treatment and could eliminate
trachoma from affected communities. As a result, the manufacturer Pfizer
agreed to donate azithromycin to trachoma control programmes for as long
as necessary and WHO established an Alliance for the Global Elimination of
Blinding Trachoma by 2020. Since 2008, 205m azithromycin doses have been
donated, and WHO elimination targets have been achieved in nine countries.
Despite the great public appetite for knowledge about life in Tudor England, until Steve Gunn
undertook a huge study of coroners' records, we knew very little about how people lived — and died.
Some of his findings shine new light on famous figures, such as the family of William Shakespeare.
Others show how ordinary people lived — at work, at home, travelling or relaxing. They reveal the
similarities and contrasts between dangers faced by our ancestors and those in modern life. The
research has inspired enormous public interest, and it has also provided a historical perspective for
organisations concerned with the implementation of health and safety policy.
Genetic skeletal diseases (GSDs) are an extremely diverse and complex
group of genetic diseases that affect the development of the skeleton.
Although individually rare, as a group of related genetic diseases they
have an overall prevalence of at least 1 per 4,000 children, which
extrapolates to a minimum of 225,000 people in the European Union. This
burden in pain and disability leads to poor quality of life and high
healthcare costs. GSDs are difficult diseases to diagnose and there are
currently no treatments, therefore, arriving at a confirmed diagnosis is
vital for clinical management, psycho-social support and genetic
Research conducted at the University of Manchester (UoM) has had a major
influence on establishing the correct diagnosis of specific GSDs by the
discovery of causative genes and mutations and the subsequent development
of accurate and reliable DNA testing protocols. This has significantly
improved both accuracy of, and access to, genetic testing in the UK,
Europe and worldwide.
The range, quantity and quality of Hispanic theatre production, film
exhibition and cultural understanding in the UK has been significantly
enhanced by the research on Spanish-language stage and screen cultures by
Professor Maria Delgado (at QMUL since 1997). The body of knowledge she
has generated has led to significant impact in three key areas: i) opening
up public discourse on Hispanic cultures; ii) improving the programming
and circulation of Spanish-language theatre and film; and iii)
contributing to creative and economic prosperity through consultancy and
advocacy in the creative industries in the UK and Spain.
The discovery of an early Acute Traumatic Coagulopathy (ATC, a syndrome
of abnormal clotting after trauma) by Professor Brohi's team in 2000, and
subsequent work building on that pivotal discovery, has led to [A] a new
understanding of why patients bleed to death after severe injury and
resulted in [B] a fundamental change in resuscitation strategy for acute
bleeding patients (`Damage Control Resuscitation') that has led to [C] a
250-300 per cent improved survival in massively bleeding trauma patients.
Discovering the character and mechanism of ATC has led to [D] new research
in diagnostics and therapeutic opportunities to further improve outcomes.
These rapid changes have led to [E] new forums for professional education
and [F] improved public understanding of science and medicine.
Music at City University London has long demonstrated a commitment to
ethnomusicological outreach. This is particularly manifested in the
extensive research of Dr Laudan Nooshin which has facilitated access to
and understanding of Iranian music and culture in Britain and
internationally. The primary channels through which impact has arisen from
this research comprise: educational work with schools; a wide range of
print and broadcast media; consultancy work for a range of organisations
and festivals; and performance work in a variety of different contexts.
Overall, the impact of Nooshin's research has enhanced knowledge of a
rich, historically-rooted culture and acted as a counterbalance to the
often negative representation of Iranian culture in the British and
international media. In particular it has influenced attitudes and
perceptions of musicians, scholars, readers and listeners; enriched the
cultural lives and aesthetic experiences of children and adults in a range
of performance and multimedia contexts; enhanced knowledge and
understanding in different educational environments; and contributed
significantly to the preservation, renewal and interpretation of Iranian
Research at the Centre for Cutaneous Research at Queen Mary has led to
gene discovery and
molecular diagnosis for a number of single gene skin disorders and
including hearing loss, inflammatory bowel disease, cardiomyopathy and
oesophageal cancer. It
has identified GJB2 mutations (encoding Cx26) as major cause of
genetic hearing loss (20-50% of
all cases) and ABCA12 mutations with the (often fatal) recessive
skin condition Harlequin
Ichthyosis. Impacts include: 1) increased medical and scientific
awareness/knowledge of the
inherited basis of these conditions, 2) changes in clinical practice and
molecular diagnosis, 3)
improved information for patients, parents and the public.
Research in dyslexia carried out within the Unit has had impacts on
practitioners and services in education, health and welfare. Pioneering
research by Dr Bahman Baluch and Dr Maryam Danaye-Tousi (University of
Guilan, Iran) on Farsi, and the relationship between orthography and the
process of learning to read, has made a significant contribution to the
ways in which reading is taught in Iran throughout the curriculum.
Research on a common underlying deficit in dyslexia by Dr Nicola
Brunswick, which lead to her appointment as Trustee of the British
Dyslexia Association (BDA), has helped improve services for people with
dyslexia in the UK.
Research on the Shahnama and the Cambridge `Shahnama Project'
have stood at the head of a
wider effort to promote a better understanding of Persian culture in
Britain and the West, especially
in view of the current negative image of Iran and its clerical regime. The
impact has been (1) to
enhance heritage activity in Iranian diaspora communities in the UK and
elsewhere; (2) create a
focus and catalyst for raising awareness amongst the wider British public
of Persian culture and
history, and of past relations between Britain and Iran; and (3) inspire
and support new forms of