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Research in Leeds led by Professor Paul Emery pioneered early diagnosis and treatment for patients with rheumatoid arthritis (RA), with the aim of disease remission rather than reduction of symptoms. This approach has transformed management of RA and is now standard practice for patients worldwide. It has led to greatly improved disease control, increased quality of life and reduced disability as well as direct productivity gains of an estimated £4 million per year to the UK economy.
Postoperative local recurrence affects 20-30% of patients with rectal cancer. Between 1993 and 2013, University of Leeds researchers identified the importance of pathology studies to show a disease-free margin around the excised tumour and how to predict this margin routinely and accurately using simple histopathology and preoperative MRI.
We also used photography in the pathological assessment of the quality of surgery and were instrumental in the adoption of modern techniques by professional organisations around the world.
Following adoption of our techniques in England and Scotland, local recurrence has halved with 10% better survival and cost savings of £60 million. Our methods have also become the gold standard in the treatment of rectal cancer patients around the world.
Sussex research has led to changes in how children are taught reading comprehension across the UK and increasingly in South America. The 2013 Primary National Curriculum for English emphasises the acquisition of skills for reading comprehension. The Independent Review of the Teaching of Early Reading, which cites many of Oakhill's research papers, fed directly into the revised National Curriculum, English. The increasing emphasis on skills for reading comprehension led Whatmuff to develop `inference training', a published training programme inspired by Oakhill's studies now used across the UK. Independently, a group of Educational Psychologists in Argentina developed a programme for primary age children, comprising a theoretical manual and work book that draws directly from Oakhill's research findings and is being implemented across South America.
Wells' research on corporate liability led to direct changes to UK law in the Bribery Act 2010 and has begun to have significant impact internationally. UK law now complies with the 1997 OECD Anti-Bribery Convention. Significant changes were made after Parliamentary scrutiny of the draft Bill, as a result of Wells' intervention, which have a major effect on all corporations, including multinationals, demonstrating the international reach and significance of this law. Her work has had further international reach and significance on the development of the OECD's Anti-Corruption Initiative and on the International Bar Association's Task Force (IBAHRI) on Tax Havens, Poverty and Human Rights.
Kim's research has had significant impact on global discourse on theology of mission across the world's churches mainly through the World Council of Churches (WCC) and the Edinburgh 2010 project. In particular her research helped to establish the pneumatological framework for mission theology evident in the Common Call of Edinburgh 2010 (6 June 2010) and the new World Council of Churches' statement on mission and evangelism, Together Towards Life (5 September 2012), which may be summarised as `finding out where the Holy Spirit is at work and joining in'.
Impact: Economics. The first cloned mammal to be created from an adult somatic cell and subsequent production of thousands of cloned animals and their progeny.
Significance: The first evidence that adult specialized cells are still capable of driving the development of a complete and fertile animal which has been translated to preserve genetic characteristics of exceptional value (e.g. competitiveness in horses)
Beneficiaries: Agriculture, livestock and equine industry, commerce.
Attribution: Essential improvements to the Somatic Cell Nuclear Transfer (SCNT) technique by Prof. Wilmut (Roslin Institute, now part of UoE) were used to clone Dolly the sheep.
Reach: Worldwide: SCNT technology has been adopted around the world, being used to clone multiple animal species.
The impact of research in computer-assisted language learning (CALL) at Ulster is evidenced by the changes it has driven regarding the delivery of language teaching using ICT and multimedia language learning tools in a variety of environments. The production of internationally-recognised research to demonstrate effective motors for change led to the establishment of a key infrastructure, the Centre for Excellence in Multimedia Language Learning (CEMLL), funded by a CETL (Centre for Excellence in Teaching and Learning) grant of £825,000 from Department of Education and Learning (DEL). This has informed developments in language teaching in higher and secondary education and has provided language learning opportunities beyond traditional educational sectors into industrial and community settings.
LSHTM researchers have developed four computer models to help decision-makers make evidence-based choices about new vaccines and vaccine schedules. These models analyse the public health impact and cost-effectiveness of different options under different assumptions and scenarios on a country-by-country basis. They are used by national immunisation managers and key decision-makers, international committees and partner organisations (e.g. the Global Alliance for Vaccines and Immunisation and the Bill & Melinda Gates Foundation). LSHTM's researchers have built on this research for WHO, informing global recommendations on vaccine timing and schedules.
Reducing the humanitarian suffering associated with conflict is a vital but demanding task, not least because continuing developments in science and technology enable ever more destructive capabilities. Brian Rappert's research has benefited international efforts to limit the consequences of the use of force. It has done this by challenging conventional wisdom, identifying poorly recognized issues; evaluating emerging policy initiatives by governments, international agencies, science academies and non-government agencies; establishing new practitioner networks; facilitating international debate; shaping international diplomatic agendas; influencing professional standards and training through the development of resources; and successfully advocating a strategy for negotiating a major disarmament treaty.
Despite the great public appetite for knowledge about life in Tudor England, until Steve Gunn undertook a huge study of coroners' records, we knew very little about how people lived — and died. Some of his findings shine new light on famous figures, such as the family of William Shakespeare. Others show how ordinary people lived — at work, at home, travelling or relaxing. They reveal the similarities and contrasts between dangers faced by our ancestors and those in modern life. The research has inspired enormous public interest, and it has also provided a historical perspective for organisations concerned with the implementation of health and safety policy.