Research in Leeds led by Professor Paul Emery pioneered early
diagnosis and treatment for patients with rheumatoid arthritis (RA), with
the aim of disease remission rather than reduction of symptoms. This
approach has transformed management of RA and is now standard practice for
patients worldwide. It has led to greatly improved disease control,
increased quality of life and reduced disability as well as direct
productivity gains of an estimated £4 million per year to the UK economy.
Postoperative local recurrence affects 20-30% of patients with rectal
cancer. Between 1993 and 2013, University of Leeds researchers identified
the importance of pathology studies to show a disease-free margin around
the excised tumour and how to predict this margin routinely and accurately
using simple histopathology and preoperative MRI.
We also used photography in the pathological assessment of the quality of
surgery and were instrumental in the adoption of modern techniques by
professional organisations around the world.
Following adoption of our techniques in England and Scotland, local
recurrence has halved with 10% better survival and cost savings of £60
million. Our methods have also become the gold standard in the treatment
of rectal cancer patients around the world.
Sussex research has led to changes in how children are taught reading
comprehension across the UK and increasingly in South America. The 2013
Primary National Curriculum for English emphasises the acquisition of
skills for reading comprehension. The Independent Review of the
Teaching of Early Reading, which cites many of Oakhill's research
papers, fed directly into the revised National Curriculum, English. The
increasing emphasis on skills for reading comprehension led Whatmuff to
develop `inference training', a published training programme inspired by
Oakhill's studies now used across the UK. Independently, a group of
Educational Psychologists in Argentina developed a programme for primary
age children, comprising a theoretical manual and work book that draws
directly from Oakhill's research findings and is being implemented across
Wells' research on corporate liability led to direct changes to UK law in
the Bribery Act 2010 and
has begun to have significant impact internationally. UK law now complies
with the 1997 OECD
Anti-Bribery Convention. Significant changes were made after Parliamentary
scrutiny of the draft
Bill, as a result of Wells' intervention, which have a major effect on all
multinationals, demonstrating the international reach and significance of
this law. Her work has had
further international reach and significance on the development of the
Initiative and on the International Bar Association's Task Force (IBAHRI)
on Tax Havens, Poverty
and Human Rights.
Kim's research has had significant impact on global discourse on theology
of mission across the
world's churches mainly through the World Council of Churches (WCC) and
the Edinburgh 2010
project. In particular her research helped to establish the
pneumatological framework for mission
theology evident in the Common Call of Edinburgh 2010 (6 June
2010) and the new World Council
of Churches' statement on mission and evangelism, Together Towards
Life (5 September 2012),
which may be summarised as `finding out where the Holy Spirit is at work
and joining in'.
Impact: Economics. The first cloned mammal to be created from an
adult somatic cell and subsequent production of thousands of cloned
animals and their progeny.
Significance: The first evidence that adult specialized cells are
still capable of driving the development of a complete and fertile animal
which has been translated to preserve genetic characteristics of
exceptional value (e.g. competitiveness in horses)
Beneficiaries: Agriculture, livestock and equine industry,
Attribution: Essential improvements to the Somatic Cell Nuclear
Transfer (SCNT) technique by Prof. Wilmut (Roslin Institute, now part of
UoE) were used to clone Dolly the sheep.
Reach: Worldwide: SCNT technology has been adopted around the
world, being used to clone multiple animal species.
The impact of research in computer-assisted language learning (CALL) at
Ulster is evidenced by the changes it has driven regarding the delivery of
language teaching using ICT and multimedia language learning tools in a
variety of environments. The production of internationally-recognised
research to demonstrate effective motors for change led to the
establishment of a key infrastructure, the Centre for Excellence in
Multimedia Language Learning (CEMLL), funded by a CETL (Centre for
Excellence in Teaching and Learning) grant of £825,000 from Department of
Education and Learning (DEL). This has informed developments in language
teaching in higher and secondary education and has provided language
learning opportunities beyond traditional educational sectors into
industrial and community settings.
LSHTM researchers have developed four computer models to help
decision-makers make evidence-based choices about new vaccines and vaccine
schedules. These models analyse the public health impact and
cost-effectiveness of different options under different assumptions and
scenarios on a country-by-country basis. They are used by national
immunisation managers and key decision-makers, international committees
and partner organisations (e.g. the Global Alliance for Vaccines and
Immunisation and the Bill & Melinda Gates Foundation). LSHTM's
researchers have built on this research for WHO, informing global
recommendations on vaccine timing and schedules.
Reducing the humanitarian suffering associated with conflict is a vital
but demanding task, not least because continuing developments in science
and technology enable ever more destructive capabilities. Brian Rappert's
research has benefited international efforts to limit the consequences of
the use of force. It has done this by challenging conventional wisdom,
identifying poorly recognized issues; evaluating emerging
policy initiatives by governments, international agencies, science
academies and non-government agencies; establishing new practitioner
networks; facilitating international debate; shaping
international diplomatic agendas; influencing professional
standards and training through the development of resources; and successfully
advocating a strategy for negotiating a major disarmament treaty.
Despite the great public appetite for knowledge about life in Tudor England, until Steve Gunn
undertook a huge study of coroners' records, we knew very little about how people lived — and died.
Some of his findings shine new light on famous figures, such as the family of William Shakespeare.
Others show how ordinary people lived — at work, at home, travelling or relaxing. They reveal the
similarities and contrasts between dangers faced by our ancestors and those in modern life. The
research has inspired enormous public interest, and it has also provided a historical perspective for
organisations concerned with the implementation of health and safety policy.