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Knowledge of the three-dimensional structures of macromolecules is a prerequisite for understanding their function at the atomic level, an essential component of modern drug development. Most structures are determined by X-ray crystallography: the majority using molecular replacement (MR, which exploits known structures of related proteins), and about half of the remainder using single-wavelength anomalous diffraction (SAD). The Phaser crystallographic software, developed by Read and colleagues, implements powerful new likelihood-based methods for MR and SAD phasing and has made a large impact, accelerating over the period 2008-2013. At the pharma giant, AstraZeneca, Phaser is considered the "tool of choice" for solving structures by MR.
Nearly every large-vocabulary speech recognition system in current use employs outputs from fundamental research carried out in the University of Cambridge Department of Engineering (DoEng) on adaptation of Hidden Markov Models (HMMs). One example of the commercial application of these outputs is their use on the Microsoft Windows desktop for both the command and control functions and the dictation functions. Approximately one billion copies of Windows have been shipped since 2008. Other examples show the outputs used in the automatic transcription of a wide range of types of data. [text removed for publication]
Dr Finnin's research has raised and enriched the profile of Ukraine as a multi-ethnic and multi-confessional cultural space bound together by projects of inter- and intra-national solidarity. His scholarly work has inspired and informed a high-profile public engagement programme, which has centred on an annual film festival launched in 2008, an annual evening of literary readings begun in 2010, and two exhibitions in 2009 and 2010. In Ukraine these outputs have in turn garnered extensive media attention, contributing to the preservation of a beleaguered cultural tradition and to the reconciliation of national communities (Ukrainian, Russian, Crimean Tatar) all with traumatic pasts.
This case study presents a dynamic development framework route-map (the Precinct Planning Design Standard, PPDS) that enhances sustainability and the delivery of a development's goals, aims, and objectives for medium-large mixed-use precinct developments and tourist resorts in developing countries. The standard shortens pre-planning timescales, achieves greater certainty in actual performance delivery and reduces environmental impact for developers, developments, and their infrastructure.
Through Earthcheck Pty PPDS is now commercially available and has been used to benchmark and certify ecological performance improvements of 30 Asia Pacific projects (US$ 25 billion development value). These range from 8,000 person community projects to medium sized tourism resorts and island developments. Our research has challenged existing standards and consequently influenced practitioners to rethink and improve the efficacy of their development processes.
Meeting rapidly rising food demands at least cost to biodiversity is one of the greatest challenges facing humanity. Since 2005, research in the Department of Zoology has demonstrated that measures to reconcile biodiversity and agricultural production are sometimes best focused on spatial separation (land sparing) rather than integration (land sharing).This work has had a significant impact on policy debate, and has informed policy decisions relating to management of the agri-environment at both national and international levels. Policy statements on increasing food production at least cost to nature now make explicit the potential role that land sparing may have, and place greater emphasis on the need for clear scientific evidence of costs and benefits of different approaches.
Research into electrochemical biosensors conducted at the University of Cambridge between 1998 and 2002 led to the development of the WaveSense™ line of diabetes products by start-up, AgaMatrix. By 2012 AgaMatrix had sold 3M glucose meters & 3B biosensor test strips worldwide across 20,000+ retail locations including Boots UK, and since 2010 also globally in partnership with Sanofi. [text removed for publication] AgaMatrix UK continues to grow its business with compound annual growth rates for revenue in excess of 100%. Agamatrix UK now supplies over one million glucose test strips per month to the NHS. Agamatrix has developed >10 FDA-cleared products since 2008, including the first FDA approved smartphone linked diagnostic device.
Starting from a mechanism-based hypothesis, Alastair Compston and colleagues in Cambridge have led the academic development of Alemtuzumab as a highly effective therapy for relapsing-remitting multiple sclerosis through Phase 1, 2 and two Phase 3 trials (1991-2012). The impacts to date are demonstration of the importance of the therapeutic `window of opportunity' in treating multiple sclerosis; a product licence in the European Union (September 2013) for the commonest potentially disabling neurological disease of young adults; expansion of the work-force in industry to develop and market this initiative; and an estimated several-fold increase in revenue to the University of Cambridge (and other beneficiaries) from total royalties of £18.6M from 1997 to date.
Abdominal aortic aneurysm (AAA) is a major cause of death in older men, in the UK and elsewhere. A large UK trial led by the University of Cambridge evaluated the long-term benefits of ultrasound screening for AAA in men aged 65-74 years. This provided the basis for the introduction of a UK national AAA screening programme in men aged 65; this was announced in 2008, initiated in 2009, and achieved full coverage of England in 2013. Similar screening has started in Sweden, New Zealand and in parts of Italy, and is being actively discussed in Denmark, Norway and Finland.
As a result of his research and publications on American history, Professor David Reynolds was invited by the Controller of BBC Radio 4 to research, write and present a series of 90 programmes, each 15 minutes in length, on the history of America. These were broadcast in three segments over a total of eighteen weeks in 2008-9. The series had a dedicated website and it remains available as a set of BBC CDs.
The series won the Voice of the Listener & Viewer Award for Excellence in Broadcasting, 2008, for the Best New Programme or Programme Series. It also received a SONY Radio Academy Award Nomination, 2009, for the Speech Award, and it was short-listed for the Orwell Prize in 2010.
The impact of Reynolds' work was demonstrated by the BBC's decision to re-broadcast ten programmes about the American Civil War in April 2011 to coincide with the 150th anniversary of its outbreak in 1861. These were also re-issued separately as BBC CDs and as a boxed set of three.
As a result of her outstanding research in Roman history and archaeology, Beard was invited to work with a TV production company to develop two programmes for BBC2. The first was a one-off programme specifically linked to her book Pompeii (2008), the second a series (Meet the Romans, 2011) related to her research on Pompeii and to her research on Roman social history and inscriptions. Recognised as landmark broadcasts (Pompeii gained 3.4 million viewers, the largest audience for a factual BBC2 programme in 2010, and was shortlisted for a BAFTA), both have led to widespread public engagement and (with major overseas sales) to considerable economic and cultural benefit to the UK.