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Postoperative local recurrence affects 20-30% of patients with rectal cancer. Between 1993 and 2013, University of Leeds researchers identified the importance of pathology studies to show a disease-free margin around the excised tumour and how to predict this margin routinely and accurately using simple histopathology and preoperative MRI.
We also used photography in the pathological assessment of the quality of surgery and were instrumental in the adoption of modern techniques by professional organisations around the world.
Following adoption of our techniques in England and Scotland, local recurrence has halved with 10% better survival and cost savings of £60 million. Our methods have also become the gold standard in the treatment of rectal cancer patients around the world.
Researchers at Swansea University were the first in the world to apply Atomic Force Microscopy (AFM) to membrane separation in the field of process engineering. Membrane optimisation processes have emerged as one of the most significant recent developments in chemical engineering, with a range of applications in, for example, the food industry and medicine/therapeutics. Research undertaken by the University has led to significant commercial and health benefits, including
Research on participation in governance and related policy instruments, with a particular focus on interest organisations and groups, with strategic orientation of research publications towards impact, and evidence of use at the highest level in public policy reviews and public discourse/debate, as well as deliberations of advocacy groups.
Research at the University of Bath on highly structured materials for adsorbing and separating gases has created business and economic impact via:
[Comment: Although beyond the cut-off date for impact achievement, as at 31 October 2013 n-psl had been acquired by the FTSE 100 listed international engineering group, IMI plc.]
UCL's research has led to changes in patient care for men with prostate cancer, through the implementation of less invasive, image-directed treatment and diagnostic strategies, and clinical trials that use these techniques. The use of medical image registration software to deliver high- intensity ultrasound therapy in a targeted manner has been shown to change the treatment plan in half of the patients participating in a clinical study. New biopsy criteria are now used routinely to classify patient risk at University College Hospital, where, since 2009, clinicians have determined the treatment options for more than 741 prostate cancer patients. The scheme has been adopted, by 15 other hospitals in the UK and internationally, where it has become the recommended standard of care, and has been used to treat more than 1,200 patients.
Two Knowledge Transfer Partnership projects, carried out between 2006 and 2009, between an e-commerce marketplace provider (@UK plc) and the University of Reading, led to the development of two software tools that were launched in 2010. The tools, SpendInsight and GreenInsight, are the first of their kind to use artificial intelligence techniques to handle the extremely challenging data associated with purchasing in large organisations. Since their launch, these tools have been used by @UK plc to identify procurement savings and environmental costs of procurement activities for governments, multi-national corporations, academic institutions and healthcare providers. Over the last three years @UK plc has benefitted from the launch of these products as it has provided them with a competitive advantage over the market place, increased the quality and efficiency of their spend analyses and led to multi-million pound licensing agreements. An analysis of spending in some of the NHS Trust Foundations has led to changes in procurement behaviours that have resulted in hundreds of thousands of pounds saved to date — benefitting not only the NHS, but also taxpayers.
Research led by Professor Hilary Footitt at the University of Reading acted as a catalyst to stimulate interest in languages in conflict situations among language practitioners, the country's principal museum of war, the Ministry of Defence, the International Association of Conference Interpreters, and NGOs. The role of languages in war and conflict had received surprisingly little previous attention and this ground-breaking research gave confidence to the Imperial War Museum to exploit the languages dimension of its collections, contributed to the Ministry of Defence's internal discussions and to its first Joint Doctrine Note on linguistic support for operations, and supported the development of the professional interpreters' Code of Conduct for the employment of interpreters in war.
Winchester's History Department has an impact on all periods of local and regional history, principally that of Wessex, engaging with:
Through an extensive and innovative programme of participation and dissemination, the University of Reading's long-term research at the Iron Age and Roman site of Calleva Atrebatum in Silchester, Hampshire, continues to change public awareness of the subtle interactions between natives and Romans in Britain and the potential of contextual and environmental archaeology for understanding town life. External interest in the Silchester Town Life Project has been cultivated, sustained and expanded over 17 years and its reach is remarkable: in the REF period alone, it has stimulated over 30,000 visits to the annual six-week excavation at Calleva and more than 30,000 unique visitors to the project website in 2012-13 alone, as well as attracting regular and extensive media coverage and considerable charitable grants and donations. Through this combination of excellent research and accessibility, the project has made a sustained and far-reaching contribution to enhancing the public's understanding of Iron Age to Roman urban life in Britain at the same time as pioneering new approaches to inclusiveness and access in archaeology.
Bishop and Danicic contributed to the development of novel spend analysis software. Launched in 2011 as a commercial service by KTP industrial partners @UK PLC, SpendInsight has been used by over 380 organisations, including Basingstoke and North Hampshire NHS Foundation Trust, which, alone, cut procurement spend by £300,000 via savings identified using SpendInsight. An analysis produced by SpendInsight for the National Audit Office identified gross inefficiencies in NHS procurement, yielding potential annual overall savings of at least £500 million. The findings of this report were discussed in parliament and changes to NHS purchasing policy were recommended as a result.