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Professor Gilbert's research identified retinopathy of prematurity (ROP) to be a major cause of blindness in children in middle-income countries and cities in Asia, and delineated those infants most at risk. Since Gilbert joined LSHTM in 2002, her research and advocacy have led to ROP being prioritised for control by the Pan American Health Organization, with regional guidelines developed for Latin America, and national guidelines in many middle-income counties. Programmes for control are expanding and improving. Six Latin American countries have made eye examination mandatory. Although difficult to quantify, these initiatives are preserving the sight of many thousands of infants.
The University of Southampton's lifecourse cohort studies have led to a paradigm shift in the medical approach to obesity and non-communicable diseases. Research linking maternal pre-conception and early years nutrition with health outcomes for later life has directly influenced public healthcare policy at international (United Nations), national (Scientific Advisory Committee on Nutrition) and local (Southampton City) levels. Dissemination through medical practice and Southampton-designed public education programmes such as LifeLab means this research has already led to health benefits for tens of thousands of people, providing them with the information and tools to help prevent themselves and their children from succumbing to a non-communicable disease.
Research at the Transport Safety Research Centre (TSRC) at Loughborough University has led to the development of a new road safety data and knowledge base called the European Road Safety Observatory (ERSO). The European Commission has confirmed in a reference that it has become a standard tool for EU and national level safety policy development and has been praised by the European Parliament. Since being established in 2006 it has been emulated at national level by many EU Member States including the UK, Spain, Czech Republic, Netherlands and France. The ERSO website now receives over 5000 hits each month from road safety policy-makers across the EU. The research, which was led by TSRC researchers, was conducted between 2004 and 2012 and in 2013 was awarded the HRH Prince Michael International Road Safety Award for its impact on road safety.
This case study is based on a series of major studies by academic staff at City University London relating to quality, safety, choice and organisation of birth in different settings. Their research has been widely cited and debated by policy, professional and user groups, nationally and internationally. The key impact has been on national and international guidelines for commissioning and on reconfiguration of services to include Midwife Units, to tackle the rising rates of intervention in childbirth and to underpin informed choice for patients. The research is being used by policy-makers, commissioners and managers to plan future services and by midwives to support informed choice discussions.
The Cambridge-led Emerging Risk Factors Collaboration (ERFC) is a global consortium involving individual-participant data on 2.5 million participants from 130 cohort studies. The ERFC has helped optimise approaches to cardiovascular disease (CVD) risk assessment by: 1) quantifying the incremental predictive value provided by assessment of risk factors 2) evaluating the independence of associations between risk factors and CVD and 3) addressing uncertainties related to the implementation of screening. ERFC publications on lipids, lipoproteins, and inflammation biomarkers have been cited by 9 guidelines published since 2010, including those of the European Society of Cardiology and the American Heart Association.
New criteria for the diagnosis of diabetes in pregnancy have been developed by the International Association of Diabetes in Pregnancy Study Groups and adopted by the American Diabetes Association on the basis of the Hyperglycaemia and Pregnancy Outcomes (HAPO) study. These new criteria double the percentage of women diagnosed with diabetes in pregnancy from approximately 8.5% to 17%. Appropriate management improves outcomes for them and their new born children. The results, which proved valid for all ethnic groups and countries, have led to a worldwide re-appraisal of glycaemic risk in pregnancy and the introduction of new guidelines to manage this.
The World Health Organisation's (WHO) Surgical Safety Checklist is the culmination of over 5 years of concerted research effort to better understand, model and intervene in human factors that affect clinical performance and patient safety in operating theatres and surgical care. Imperial researchers were instrumental in the set up and implementation of the WHO `Safe Surgery Saves Lives' working group, launched in 2006, from which the Checklist was a primary outcome. Subsequently, we were co-investigators, and UK-lead, in a global study the implementation of the Checklist in 8 pilot hospitals across 7 continents. The Checklist was demonstrated to significantly improve patient outcomes and was modified and mandated for use in all NHS surgical procedures in England by the National Patient Safety Agency. We have since lead a national study that evaluated the implementation of the Checklist within the NHS and successfully delivered a team training programme aimed at optimising use of the Checklist in our hospitals.
The ultimate goal of in-vitro fertilisation (IVF) therapy is the live birth of a single, healthy child. However, issues of treatment failure, complications and multiple births (twins or triplets) continue to persist and have a major impact on patient quality of life. Pioneering research at the University of Glasgow has driven the concept of personalised IVF therapy and outcome prediction, reforming clinical guidelines and defining criteria for access to funded IVF therapy. This research has stimulated revision of UK regulatory policy on the number of embryos transferred during IVF. These strategies underpin the recommended practice for the 48,000 women undergoing IVF in the UK each year. In addition, the Glasgow team's online, personalised `IVFpredict' calculator, which women can use to predict their success of a live birth, has been completed by more than 5 million users worldwide.
Research on the theoretical and experimental assessment of the stability of damaged ships in the Department of Naval Architecture and Marine Engineering from the mid-1990s to the present day has been pivotal in the development, adoption and implementation of the latest amendment of the International Convention on Safety of Life At Sea (SOLAS 2009) by the International Maritime Organization (IMO), the UN body regulating maritime safety. The impact of these regulations has been a significant reduction in the risk to human life at sea by enabling ship design and operation with higher standards of damage stability. SOLAS 2009 represents a step change from deterministic to probabilistic rules and from rule compliance to goal-based standards; it has improved design and operation of all commercial ships built worldwide from 2009, and has thus resulted in far-reaching and long-lasting impact on maritime safety.
Research at the University of Nottingham (UoN) has had influence on development of health policy in the UK and internationally. It is recognised that the risk of diseases related to obesity and insulin resistance, is partly determined by the nutritional environment experienced during early life. Against a background of scepticism researchers at the UoN have generated data that has been critical in demonstrating the biological plausibility of such associations. This has influenced expert panels and non-governmental organisations in framing their current recommendations for nutrition in pregnancy and infancy, which benefit women and children worldwide.