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This case is primarily based on the economic benefit derived from commercialisation of intellectual property arising from our research programme in materials at the XMaS beamline at the European Synchrotron Radiation Facility at Grenoble. The company Huber Diffraktiontechnik GmbH and Co. KG have had direct commercial benefit from exploitation of instrumentation we have developed, in collaboration with Warwick University, to address the specific research challenges described below. A second, indirect, impact of XMaS is knowledge transfer through the career progression of trained specialists in positions at other large scale science facilities and in the private sector.
This case study describes impact from the Newcastle-led research project to construct the world's first dedicated single-crystal diffraction synchrotron beamline for chemistry and materials science at Daresbury Laboratory Synchrotron Radiation Source (SRS). The result was an innovative and productive facility that has served as the model for the development of other facilities internationally, especially at Diamond Light Source (UK) and the Advanced Light Source (USA). The original Newcastle University research has helped produce scientists now employed by industry and public service sectors around the world. Major new and beneficial drugs and catalysts have been developed with the aid of the synchrotron beamlines and work conducted at these facilities has been critically important for the advancement of the global chemical and pharmaceutical industries and US Government energy development programmes.
Keele University has made sustained and seminal contributions to the development and use of central facilities (Synchrotron radiation, Neutron scattering) which started over 30 years ago and are still in progress today. Past and present academics at all levels from Keele who began this work have gone on not only to carry out their own ground breaking research using these facilities but, in many cases, to have a major social, economic and industrial impact, through key roles in development, support and techniques and through the present, current and next generation of scientific, management and technical expertise at Central Facilities around the world. This includes numerous postgraduate students, Research Associates and academic staff. The contribution to Science and Technology has enabled significant breakthroughs in many aspects of science and medicine, accompanied by direct economic and social impact and a unique and ongoing contribution to the current generation of SR and neutron sources, their scientific staff and their users.
Durham Chemistry has a long history of research in cutting edge crystallographic methods and innovative instrument design which has led to the commercialisation of scientific apparatus and software with significant sales value. Durham-developed apparatus and crystallographic software are used globally by both industry and academia. Autochem2, for example, is sold exclusively to Agilent via the spin-out company OlexSys, and hundreds of researchers rely on Durham's contributions to the Topas software pacakge. Crystallographic research for pharmaceutical and other companies, research-based consultancy, commercial analytical services and provision of international PhD+ level training schools have led to further significant impact.
Research at the University of Cambridge, Department of Physics on sensitive techniques for measurements of magnetic and electrical properties of materials led to the selection of Dr Michael Sutherland as an expert witness in a series of major police investigations involving fraudulent bomb detecting equipment. Scientific evidence Dr Sutherland presented in court was key in securing guilty verdicts, leading to the breakup in 2013 of several international fraud rings with combined revenue in excess of £70 million. This criminal activity had caused significant damage to the reputation of the UK in Iraq and elsewhere.
Our research on the physiological effects of the electromagnetic fields generated in magnetic resonance imaging (MRI) has been used by: (i) the International Commission on Non-Ionizing Radiation Protection (ICNIRP) and the UK Health Protection Agency (HPA) in establishing advisory limits and action values in their published regulatory guidelines; (ii) the EU Commission as part of the evidential basis in their decision to derogate MRI from the scope of the Physical Agents Directive 2004/40/EC. These decisions have enabled the continued operation of MR scanners across Europe, safeguarding the access to MRI for 500 million people. The economic benefits arising from the manufacture of MRI equipment were also secured. Our work has thus resulted in impact on public policy, the economy and healthcare.
This case study describes the invention, development and subsequent commercial application of the floating low-energy ion gun (FLIG), a key enabling technology for high-resolution depth profiling, in particular of semiconductor devices. Following its invention at the University of Warwick, the FLIG was commercialised and now plays an important role in the semiconductor industry as a key analytical instrument. Intel and its competitors have used the FLIG in developing specific technologies, such as the PentiumTM, XeonfTM and CoreTM i7 processors. Its impact extends beyond the electronics industry to consumers worldwide since the FLIG has played a key role in the development of multicore processors for personal computers, intense low-energy lighting for automotive and civil engineering, mobile telecommunications technology, and many other areas of advanced electronic, and other material, technologies. This invention has also led directly to an ISO standard for depth resolution.
Our development and demonstration of the world's first ns-FFAG accelerator (EMMA) and our expertise in exploiting and extending the capabilities of GEANT4 simulations have enabled us, in a relatively short time, to demonstrate societally significant applications of advanced particle accelerator technology. This research, which has garnered significant commercial and media attention, has demonstrated the feasibility of compact, reliable and affordable proton machines for cancer therapy [C], radioisotope production [A,B] and muon [F] and neutron [E] production, thereby offering UK industry a technological lead in a potentially enormous international market. Additionally, our research in accelerator driven technologies had played a significant role in establishing the scientific and political case for the construction of the 1.5b€ European Spallation Source in Lund, Sweden, and is influencing developments at Fermilab in the US [E,F].
A software package called CPO has been developed that simulates the motion of charged particles in electromagnetic fields. More than 200 benchmark tests have established CPO as the gold standard in low-energy charged-particle optics. A spin-off company was formed to market CPO, [text removed for publication]
Heat capacity is the measurable physical quantity that specifies the amount of heat required to change the temperature of an object or body by a given amount and is an important quantity to establish in any application that requires knowledge of the thermal response of a material. It is quite usual in the development of new materials that the volume of material available in single crystalline form is limited, and the ability to measure small samples sensitively has particular importance for this reason. We claim a dominant influence on the design of an ultrasensitive heat capacity microcalorimeter that is now sold by the UK company Cryogenic Ltd as a heat capacity option for their cryogenic measurement systems. The microcalorimeter makes it possible to measure ultra-small samples, particularly magnetic samples that are invisible to other commercial probes. Research was carried out within Imperial's Physics Department in 2003-04 to develop the instrumentation; the design was published in 2005 after which it transferred to UK company Cryogenic Ltd. In the past three years the approximate total sales of the heat capacity option at Cryogenics amount to £500K, as a valuable component of a physical properties measurement system with a total sale value in the region of £2M [section 5, source E].