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Depression is a major public health problem producing substantial decrements in health and well-being, with 15% lifetime prevalence, affecting 350 million people worldwide. The Mood Disorders Centre (MDC) has improved treatment for depression by (i) understanding psychological mechanisms underpinning depression; (ii) translating this into innovative treatments and prevention interventions, evaluated in clinical trials; (iii) improving dissemination, delivery, and access to treatments. This research has improved patient care and quality of life, influenced national policy (NICE Depression Guidelines), informed national service and training provision (Improving Access to Psychological Therapies IAPT programme, with 680,000 people completing treatment 2008-2011) and achieved international impact on clinical practice.
An estimated one in four people in the UK will experience depression or anxiety at some point in their lives. Cognitive behavioural therapy (CBT) is the most widely recommended non-medication- based treatment for common mental health problems, although access to this treatment is limited because of low numbers of expert practitioners. Self-help CBT resources developed by researchers at the University of Glasgow have been integrated into routine clinical practice delivered by health services and the voluntary sector in the UK, Ireland and Canada. Since 2008, these practical user-friendly resources have provided support to over 200,000 users online and an estimated 250,000 people on a one-to-one basis or within a class.
Depression is a major public health problem, producing substantial deterioration in health and well- being and costing the UK £billions annually. A programme of research at Exeter, led by Professor Richards, (trials and Phase IV implementation studies) has changed national policy on the treatment of depression (NICE guidelines). It has also underpinned the UK's Improving Access to Psychological Therapies (IAPT) programme which has been widely implemented, leading to new treatment for over 1 million people, with a recovery rate in excess of 45%, and over 45,000 people coming off sick pay and benefits. The research has also achieved International impact.
Research at Edinburgh Napier University regarding psychosocial interventions for trauma has pioneered management of mental health problems. We have developed and tested a number of individual, group and self-help interventions aimed at promoting recovery following psychological childhood and adulthood trauma. We have trained a large number of healthcare professionals on our interventions in the voluntary and statutory sectors. Our research has also informed policy regarding the management of psychological trauma. Self-help materials developed through our research are currently being used by health and social care workers in Scotland and abroad, making an impact on the wellbeing of survivors of trauma.
Dr Lina Gega's research has been instrumental to the development and take-up of computerised Cognitive Behavioural Therapy (cCBT) and other technology-mediated interventions for common mental health problems in the UK and internationally. Gega's adjunct on-line methods form a key foundation for the training of professionals to support cCBT, and the National Institute for Health and Care Excellence (NICE) guidelines now include cCBT for first line intervention for common mental health problems. These developments have resulted in a greater patient reach for cCBT internationally, with resultant decreases in waiting time for patients (with associated economic benefit) and improved outcomes.
Lancaster research has changed the understanding and treatment of bipolar disorder (BD) from biological models and pharmacological treatments to integrated psychosocial interventions complementary to routine medication and matched to user needs. We have developed novel psychological interventions (individual, family and group approaches), and reliable and valid ways to assess valued outcomes and underlying mechanisms of change. This research has delivered 3 major impacts. It has: fundamentally changed understanding of the condition in professional and lay audiences; changed treatment in terms of policy and practice, including NICE clinical guidelines; changed professional training delivered both nationally and internationally.
York research showing that a) screening for depression in primary care is ineffective and b) collaborative and stepped care improves outcomes for depression in primary care, has changed national and international policy. The National Institute for Health and Care Excellence (NICE) revised its guidelines, the National Screening Committee altered its recommendations, and money has been saved by no longer paying GPs to screen for depression under the Quality and Outcomes Framework. US advisory bodies have also shifted away from recommending routine screening for depression. Treatment guidelines/programmes in the USA, Europe and Australia now recommend collaborative care for the management of depression. Our research has also resulted in an expansion of the NHS Improving Access to Psychological Therapies programme, with many patients benefitting from improved care. The computer support system (PC-MIS©) we developed to record treatments and to track patient progress over time is the most widely used in the NHS. The clinical performance benchmarks we derived from this form the basis of metrics used for NHS-wide performance management of depression services.
There are very few evidence-based psychological interventions for people with Alzheimer's disease and other dementias. Of these, cognitive stimulation has the strongest evidence-base. Developed by Bob Woods (Bangor University) and Martin Orrell (UCL) in the late 1990s, the approach has proven effective in maintaining both cognitive function and quality of life. Recommended in guidelines around the world for use with people with mild to moderate dementia as the major evidence-based non-pharmacological intervention, it has assisted literally thousands of people with dementia and their carers globally to have a better quality of life both before and since 2008.
A research programme of multi-centre clinical trials led by Professor Suzanne Hagen has established Pelvic Floor Muscle Training (PFMT) as an effective treatment for women with prolapse. Hagen's team has also successfully developed a Prolapse Symptom Scale and further tested a Prolapse Staging System to improve outcome measurement for women's health physiotherapists in the UK (20% and 15% clinical uptake respectively). The research has informed local, national and international guidelines and changed practice in 48% of UK physiotherapists. The research has also raised awareness of PFMT treatment for prolapse, with 70% of UK physiotherapists reporting an increase in prolapse referrals.
Jacqueline Barnes' evaluations of government initiatives promoting parenting and child development for vulnerable families have directly affected major policy decisions since 2008. Her study of the Home-Start programme demonstrated limited benefits of unstructured volunteer support, and informed recent NICE guidance on early intervention. Her subsequent evaluation of the Family Nurse Partnership (FNP) programme for vulnerable mothers changed government policy. The success of FNP, as demonstrated during the initial evaluation phase, led to ministerial decisions to more than double the provisions of this programme in 2010 and 2013. FNP has now been rolled out widely in England, Scotland and Northern Ireland.