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Novel vapour sorption experimental methods for the characterisation of complex particulate materials have been developed in the Department of Chemical Engineering. This research and expertise resulted in the creation of Surface Measurement Systems Limited (SMS), whose Dynamic Vapour Sorption (DVS) and Inverse Gas Chromatography (IGC) instruments are now found in >500 laboratories around the world. They are recognised standard research and development tools in the global pharmaceutical industry (DIN 66138). SMS has contributed >270 man-years of employment and generated £27M of turnover, whilst SMS instruments have generated over £300M of economic value, over the REF period.
New low thermal conductivity (low K) barrier coatings, developed at Cranfield, reduce specific fuel consumption by over 1%. Commercial variants are now implemented on the Trent 1000, used to power the Airbus 380, and the Trent XWB, the new engine to power the Boeing Dreamliner aircraft.
Our thermal barrier coating (TBC) systems have improved thermal efficiency in gas turbines. Low-K TBCs will save 14MtCO2e over the 20 year life of the engine. Adjustment for the effect of emissions at high altitude increases the calculated benefit to 26.6MtCO2e. In fuel costs, this saves operators £1.8 billion over the REF14 period considered and £3.4 billion over the engine lifetime.
Graham Buckton's work at the UCL School of Pharmacy has involved the development of new techniques, which are now industry standards, for assessing the amorphous content of materials in inhalation products. This work has had a significant influence on both manufacturing quality control and regulatory requirement, including informing FDA policy, to the effect that this type of assessment is now a requirement for licensing of powder inhalation medicines in the US and Europe. Benefits to drug companies include cost savings and more reliable production. Furthermore, the associated School of Pharmacy spin-out company, Pharmaterials, offers these assessments as a core part of its commercial activity, with a large client base of industrial partners who require such assessments for their inhalation and other products. The overall result of this work has been changes and improvements in the design, control and manufacture of inhalation products.
The cost of goods is an especially important issue in developing commercially available agrochemicals, which must be manufactured on a large scale. Richard Compton's research at the University of Oxford has led to a step change in the understanding of heterogeneous reaction mechanisms for liquid — organic solid or liquid — inorganic solid processes involved in large-scale manufacturing processes. Compton's work has had particular impact on optimising the processes used by Syngenta AG in its manufacturing of agrochemicals. Since 2008 the insights gained on inorganic-base dissolution have been of great benefit to Syngenta in its development of scalable robust manufacturing processes, particularly in relation to production of its fungicide Amistar and insecticide Actara, which are two of the world's largest selling products of this type. In 2012 Syngenta achieved total sales of over $ 14 billion, $ 4.8 billion of this from fungicide and insecticide revenues.
Basic research combining scanning probe microscopy with thermal, spectroscopic and chemical analysis has enabled the development of powerful, entirely new forms of analytical microscopy. Commercialisation of instruments for micro-thermal analysis began by TA Instruments, in 1998, based on four patents, followed by a Lancaster start-up company Anasys Ltd. These instruments have since been extensively used in multidisciplinary applications by scientific industry and government laboratories. Anasys has sold over 100 units of these nanoscale thermal analysis instruments (total turnover £3M) and many leading polymer industries, research institutes and academic programs worldwide are now users of this technology.
Durham Chemistry has a long history of research in cutting edge crystallographic methods and innovative instrument design which has led to the commercialisation of scientific apparatus and software with significant sales value. Durham-developed apparatus and crystallographic software are used globally by both industry and academia. Autochem2, for example, is sold exclusively to Agilent via the spin-out company OlexSys, and hundreds of researchers rely on Durham's contributions to the Topas software pacakge. Crystallographic research for pharmaceutical and other companies, research-based consultancy, commercial analytical services and provision of international PhD+ level training schools have led to further significant impact.
The technology in this impact study is based on organofunctionalised silica materials that can address market needs for high purity in compounds that underpin many areas of the pharma, electronic and medical sectors as well as the recovery of limited resources such as precious metals that are used in diverse industries. Since the launch of the product portfolio in 2006, the materials have become embedded in purification or recovery steps in commercial production processes of leading mining (South Africa), pharmaceutical (UK) and petrochemical (Germany) companies and make a significant impact on the business of these companies as well as limiting waste of limited resources.
Research at Kingston University into the use of flame spray pyrolysis (FSP) to manufacture metal oxide nanoparticles has resulted in the creation of an industrial FSP nanoparticle production line. This achieves production rates an order of magnitude higher than was previously achievable, while allowing particle size to be controlled at the same scale as existing small FSP processes.
TECNAN, a Spanish SME, established in 2007, that manufactures and sells nanomaterials on the international market, has used this production line to produce a range of nanoparticles for commercial customers, for use in a wide range of applications. As well as allowing a broad product range to be offered, the production line also achieves a cost reduction of over 30% compared to previous manufacturing methods.
The unique application of combinatorial chemistry in materials science at Southampton has directly underpinned the success of University spin-out, Ilika Technologies. Since 2008, the breadth of applications of the research has allowed Ilika:
Between 2008 and 2012, Ilika enjoyed considerable growth, doubling employment to 35 staff, increasing turnover by approximately 25% annually, and floating on the AIM with a market capitalisation of £18.7 million.
Since the mid-1990s, the Materials and Structures Research Group has been conducting research into materials-joining processes, including metal-ceramic joining for high-temperature applications. The group's research on metal-ceramic interfacial relationships and metal-ceramic joining subsequently assisted Cambridge-based C4 Carbides to optimise metal-to-diamond brazing and develop cutting tools with improved quality and longer lifetimes. Since 2010 the company has also [text removed for publication]
This continuing collaboration has helped C4 Carbides secure a TSB smart award and begin its strategic shift from niche SME to mainstream supplier.