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Changing global patterns of agricultural production, food availability and processing are having profound impacts on individual food consumption and population health. Thus accurate data on individual food consumption are fundamental for effective planning of agricultural investments and for the implementation of sound public health nutrition policy. Research undertaken at the University of Ulster has demonstrated that mis-reporting in dietary surveys is pervasive and consequently is obscuring diet-health associations. This research has prompted a major paradigm shift in the way public health policy makers interpret dietary intake data.
Over the past 15 years, research within the Nutrition and Metabolism in Health and Disease Theme has provided evidence to inform policy and practice in the nutritional care of older and nutritionally-vulnerable adults. This information has been referred to by other bodies when improving guidelines for nutritional management and care in residential or community settings. Theme members have identified key changes in nutritional status and dietary needs which occur with advancing age; these observations have contributed to the development of standards associated with nutritional, food and fluid provision for the care of vulnerable groups in hospitals and care homes in Scotland and beyond.
Imperial College research on the gut hormone, oxyntomodulin, showed it caused considerable weight loss in man. A powerful long acting analogue suitable for daily human administration (TKS1225) was developed. This was licensed by Imperial to a spinout, Thiakis Ltd, for successful human toxicity testing and then sold to Wyeth for $30 million initially and $120 million on meeting milestones. Wyeth Pharmaceuticals and the full legal agreement was subsequently acquired and developed by Pfizer in 2009.
Since 1993 researchers from the University of Leeds (UoL) have devised robust and standardised experimental methodologies to study human appetite and food consumption objectively. Companies in the food and pharmaceutical sectors have used these procedures to develop functional foods and anti-obesity drugs. The validated methodologies also allowed global clinical research organisation Covance to establish its Human Appetite Laboratory to provide product evaluation for US and EU pharmaceutical companies. Food regulators have also recommended the Leeds approach for producing evidence to support appetite control claims for functional foodstuffs.
Although an adequate micronutrient intake and status is necessary for health and deficiency disease prevention, an excess dietary intake may have deleterious effects on health. Our impact has been to inform, stimulate and move forward our understanding of micronutrient requirements across the human lifecycle. Our activities have led to the development of WHO, EU and national nutrient intake recommendations which have had a significant impact on public health policies and initiatives which address food security.
We provided specialist expertise to the WHO Guidance Expert Advisory Group for assessing the effects of potassium and sodium intakes on human health. As a result, WHO has developed its first dietary guideline on intakes of potassium (adults and children) and sodium (children) for cardiovascular health.
Our original research in micronutrients including iron, zinc and fluoride and our systematic review approach have generated the evidence required for deriving nutritional recommendations, exemplified by our contribution to European dietary reference values (DRVs). These are used by member states to produce national health policies, guidelines and nutrient intake recommendations.