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Radiation sources and amplifiers, in the spectral region from microwave to terahertz, are extensively used in UK industry and public sectors such as security, defence, health and the environment. Companies, including e2v Technologies plc. (e2v) and TMD Technologies Ltd. (TMD), have developed and sold new radiation products based on post-1996 research undertaken at the University of Strathclyde. Their devices accessed new frequency ranges with considerable increases in power and bandwidth. The designs were transferred to industry, where devices have been constructed, jobs created, policy changed and considerable investments made. These sources have had extensive beneficial impact through applications in defence, surveillance, materials processing, health sciences and environmental monitoring.
The development by Cambridge University staff of compact semiconductor sources and detectors of Terahertz radiation has opened up this part of the electromagnetic spectrum to commercial use for the first time, enabling many applications. In medicine these applications include the analysis of drugs and the detection and imaging of cancer; in security applications the detection and imaging of explosives; and in the semiconductor industry the detection and imaging of buried defects in semiconductor wafers. High power Terahertz lasers are used in gas sensors, for imaging and as local oscillators. This technology has been exploited by a spin-off company TeraView which has 25 employees, has raised £16M in funding, £3.5M since 2008, and has sold 70 imaging systems, half since 2008 at an average cost of $300K each.
Dr Dickinson (Bioengineering) collaborated with Professor Habib (Surgery) to develop novel methods for removing or starving tumours. Resection (removing part of an organ) is theoretically an ideal method for treating liver cancer as the liver can regenerate, but it causes extensive blood loss. The Bioengineering team developed a bipolar electrode system that employs RF current to coagulate a track in the liver; the track can then be cut without bleeding. Prototypes were successfully tested in pre-clinical and clinical trials. 20,000 single-use devices (value: US$40M) have been sold under licence by AngioDynamics, with an estimated saving of >800 lives. Complications, intensive care, blood transfusions, and hospital stay have also been dramatically reduced. Dickinson developed further bipolar devices for maintaining the patency of ducts during pancreatic and biliary cancers, for ablating liver tumours and for blocking tumour blood supply. Sold by Imperial spin-out Emcision, these are also in current clinical use.
Practical Waveform Engineering, developed at Cardiff, is having a major impact on how modern- day microwave power amplifiers are designed, delivering real competitive advantages for global communications companies such as Nokia-Siemens-Networks and M/A-COM.
Economic impact is through reduced time-to-market and lower design costs, leading to high- performance power amplifier products. Examples include $40M revenue and employment of additional staff for M/A-Com, and the successful spin-off company Mesuro Ltd., generating revenue in excess of £2.5M.
Impact on practice is through successful demonstration of new device technologies and amplifier architectures, the introduction of PWE-based CAD models, and most significantly, the introduction of the "Cardiff Model" into mainstream simulation tools.
Environmental Impact is by improving the efficiency of power amplifiers and significantly reducing the carbon contribution of mobile communications systems, translating into savings of approximately £2.5M/year and a 17 kiloton reduction in CO2 emission for a typical EU network.
Our research on semiconductor materials and devices has led to the establishment by e2v Technologies of a combined manufacturing, research and development facility within the School of Physics and Astronomy. We have adapted and transferred device simulation software to e2v, and have provided epitaxially-grown semiconductors and access to fabrication facilities which have been used in their manufacturing processes. Devices fabricated within the facility, which was opened in 2011, have generated sales of £7M for e2v. This initiative has also led to shifts in the investment priorities of e2v, and mitigated risks to the company arising from import restrictions associated with the US International Traffic in Arms Regulations (ITAR).
Metamaterials deliver electromagnetic properties not available in natural materials. Transformation optics replaces the ray picture of Snell's law with the field lines of Maxwell's equations and is an exact description of classical optics. These powerful concepts, originally developed by Prof John Pendry, have engendered massive interest in the electromagnetic community encompassing radio frequency (RF) through to optical applications. His advice is sought by numerous companies and these concepts are now filtering through into products. In the last 5 years there has been great involvement of industry and particularly of the defence establishment in the USA who run several multi mullion dollar programs on metamaterials based at DARPA, WPAFB and Sandia. A company, KYMETA, was formed in 2012 to market this technology with $12M of investment funding, and is developing a laptop-sized antenna that gives instant Internet hotspot access anywhere in the world, with an ultimate application allowing cheap and fast Internet connections for the everyday consumer. In the UK, BAE Systems is using metamaterials for several applications including compact, directional antennas.
Research on high-voltage power devices by the University of Cambridge Department of Engineering (DoEng) was commercialised by its spin-off company, Cambridge Semiconductor Limited (CamSemi), which, in the REF period, has:
CamSemi chips are more efficient than traditional linear power supplies. The CamSemi chips that were produced before the end of the REF period are estimated to save of the order of 100GWh of electricity and 50,000 tonnes of CO2 emissions per year in total.
Novel biological scaffolds that regenerate with the patient's own cells have been researched, and patented and since 2008 developed, taken through successful clinical trials and commercialised. Economic impact within the REF period has been delivered through the University of Leeds spinout company Tissue Regenix plc, which has received £32M private investment, employs 35 people and is AIM listed, with a capital value of £70M. Health impact has been delivered through licensing and development by NHS Blood & Transplant Tissue Services. The biological scaffolds have demonstrated five years' successful clinical use in heart valve replacement and three years' clinical use as a commercial vascular patch.
Research at the University of Leeds, in partnership with the US company Agilent Technologies, has directly resulted in the development of high performance vector network analyzer instrumentation used by electronics, aerospace and defence companies globally to measure the high frequency properties of electronic devices and materials. University of Leeds research also directly resulted in the development of two further Agilent Technologies products — a high frequency dielectric probe kit and a capacitance scanning probe microscope. Agilent Technologies confirms that the collective sales of these products are in the region of tens of millions of dollars annually since 2008.
The impact of this research has been of commercial benefit for TgK Scientific Ltd, a Wiltshire- based SME, who have successfully commercialised a FT-IR Stopped-Flow instrument. This has achieved market share as a result of incorporating an innovative cuvette designed and fabricated by the University of Birmingham's School of Biosciences. The company has sold nine of these instruments since they were first marketed in 2008, generating ~£200,000 in sales. This has made a substantial contribution to the company's total sales, most obviously in 2012 where sales of four instruments accounted for around 10% of their ~£800,000 turnover. The instrument allows the study of fast biological reactions by rapid scanning Fourier Transform Infrared Spectroscopy. The Birmingham contribution is a cuvette of a unique design that enables biological materials to be mixed and observed after 2-3 ms, allowing enzyme-catalysed reactions which have non- chromophoric substrates to be studied in physiological conditions. TgK have combined the cuvette with their stopped-flow drive system and a spectrometer produced by Bruker to make a complete apparatus; it is believed that this gives the instrument a unique functionality valued by a significant niche market.