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Pre-eclampsia is a major contributor to death and disability in pregnancy. Diagnosis, based on accurate blood pressure (BP)/proteinuria determination, is limited by measurement errors and being late features of the disease. In collaboration with industry, King's College London (KCL) researchers have developed an inexpensive, accurate, simple BP device suitable for rural clinics. This device allows intervention to reduce mortality/morbidity and is currently being rolled out in a Gates Foundation project in Africa and Asia. KCL researchers have also helped the company Alere Inc. with the development of a diagnostically accurate test of placental growth factor (PlGF) in women with suspected pre-eclampsia: Alere Triage®PlGF. This demonstrates high sensitivity, superior to current tests, and following commercialisation is being adopted internationally. Their work is additionally reflected in guidelines of international standards for BP device accuracy.
Karl Gerth's work on the role of Chinese consumers in the global economy, and on ways in which Chinese consumerism may create more environmental and policy problems than it solves, has had a significant influence on business leaders seeking to position themselves in the Chinese market, as well as on public discourse around the `rise of China'. Gerth has extended the range and quality of the evidence on the interconnected and wide-ranging ramifications of the shift within China toward a market economy over the past thirty years, and has improved understanding of this phenomenon in ways which have enabled British business to compete more effectively in China.
Exeter Drama's research in Applied Theatre has had impact in the improvement of community understandings of mental health, providing professional development for medics and teachers, and providing and informing training in applied and community theatre. This case study outlines the impact of last twenty years of research and performance practice in applied theatre, developed by Honorary Research Fellow (2005-) and former senior lecturer (1990-2005) John Somers, and continued in the work of Fiona MacBeth, Kerrie Schaefer, Sarah Goldingay, Anna Harpin, and Jane Milling. Somers developed new approaches to community theatre and has given presentations on this work internationally. Impact has also been achieved through Somers' founding of the applied theatre company Exstream (Exeter, 2001) and under his direction Exstream achieved a reputation for excellence through the development of interactive theatre, raising awareness of issues related to wellbeing, mental health, and creativity within the community.
The project led to improved public access to partner collections via a major website, informed the design of the £10m HLF-funded Birmingham History Galleries of Birmingham Museum and Art Gallery (including innovative multi-touch software), and firmly embedded a culture of cross-sector collaboration with impact in Birmingham, the Midlands, and beyond.
Research on high-voltage power devices by the University of Cambridge Department of Engineering (DoEng) was commercialised by its spin-off company, Cambridge Semiconductor Limited (CamSemi), which, in the REF period, has:
CamSemi chips are more efficient than traditional linear power supplies. The CamSemi chips that were produced before the end of the REF period are estimated to save of the order of 100GWh of electricity and 50,000 tonnes of CO2 emissions per year in total.
Spatial models developed from research in the School of Geography about population movements in cities are informing commercial planning and public policy analysis. The conduit for this impact is GMAP Ltd., a spin-out company established by the University of Leeds, which has used the models as the basis for its MicroVision and RetailVision software. Companies including Ford, Exxon, HBoS and Asda-Walmart have used this software for a range of purposes including maximizing individual stores' profitability and reconfiguring entire networks to fit changing market conditions. Government agencies have also used the software to optimize resource allocation in policing, education and healthcare.
This case study details the impact of a pioneering theoretical approach to English language testing. Recognised as the most influential test validation theory in modern assessment, the socio-cognitive framework, conceived by Weir and O'Sullivan, and operationalized and developed further by O'Sullivan at the University of Roehampton, focuses on three key elements: the test taker (social), the test system (cognitive), and the scoring system (evaluative). This framework is applied to give a meaningful measure of a candidate's performance, appropriate to the underlying traits or abilities being assessed. This research has had a significant impact in two distinct phases: 1) through a series of commissioned projects since 2008, the research has had a significant impact on testing bodies, organisations and test takers internationally, and 2) it has underpinned the development of innovative new business products by a leading international educational and cultural organisation since 2012.
Chemtrix Ltd. was established in February 2006 as a 50-50 joint venture between the University of Hull and Lionix Ltd. In 2008 the company attracted investment from Limburg Ventures BV, Panthera, Technostartersfund, Microfix BV and Hugo Delissen (€2 million) that led to the creation of Chemtrix BV. In 2009 the Company launched Chemtrix USA and a second investment round followed with investors Particon BV. In 2012 ESK Ceramics GmbH & Co. KG, acquired a minority interest (30%) in Chemtrix BV based on a valuation of €5.3 million.
The three products developed and marketed by Chemtix, Labtrix®, KiloFlow® and Plantrix®, are differentiated from competitor products as they offer `scalable flow chemistry', such that optimised reaction conditions can be easily scaled from R&D to production. In addition to the employees and investors in Chemtrix the main non-academic beneficiaries of the research have been industrial customers such as Janssen Pharmaceutica NV, Edward Air Force Base, Iolitec GmbH and DSM.
The psycholinguistic framework for research and practice developed by Stackhouse and Wells is now a key component of the majority of UK speech and language therapy courses at undergraduate and postgraduate levels. In addition to influencing the design and delivery of course curricula in the UK, Europe, Australia, South Africa and USA, the framework is used in continuing professional development for speech and language therapists (SLTs), special needs teachers, and with parents. The resultant impact on clinical and educational practice, the assessment of children and the planning of therapy interventions can be seen across the spectrum of persisting speech difficulties, including those related to dyspraxia, dysarthria, dyslexia, cleft palate, Down Syndrome, stammering, specific speech and language impairments.
Pioneering research at Essex developed an innovative mathematical method for determining the chlorophyll fluorescence parameter Fo', as well as novel LED lighting technology and a multi-plant imaging system. This instrument is marketed by Technologica. Originally an Essex spinout, the company has sold 42 units across Europe, Asia and South America since 2006, recording its highest ever profits over the past three years (totalling ~£115k). Essex's mathematical method for determining Fo' is also used by other manufacturers, who have since developed their own imaging systems. This research has helped to establish chlorophyll fluorescence imaging as a mainstream screening tool, now used globally to inform a range of crop production and handling strategies.