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Rosengarten's work during the past fourteen years has provided the HIV field with new ways of rethinking otherwise seemingly intractable problems of more effective prevention. Despite over 30 years of biomedical and social research, and policy and programme implementation, the HIV epidemic continues to grow. The efficacies of repurposing potentially toxic and partially effective antiretroviral drugs for prevention in those perceived at risk of infection has thus come under scrutiny. It is in this context that Rosengarten's work has intervened and introduced an alternative approach to prevention that directly scrutinises the social contexts in which people live and work with HIV. Through this approach and her active engagement with clinicians, policy makers, scientists and advocacy groups she has contributed critical insights that have been incorporated into approaches to HIV prevention in practice.
HIV-infected infants are at high risk of disease progression and death. Until 2008 guidelines recommended waiting until the infant displayed symptoms, or had a weakened immune system before starting treatment. The CHER trial found that starting infected infants on antiretroviral therapy as early as possible substantially reduced mortality compared with waiting until they developed symptoms or their immune system weakened. These results led quickly to changes in guidelines for treating HIV-infected infants issued by the US, World Health Organisation (WHO), Paediatric European Network for Treatment of AIDS (PENTA) and South Africa. These revised guidelines, if fully implemented along with early infant diagnosis, would reduce the number of infant deaths because of HIV by 76%, saving the lives of approximately 46,800 infants globally each year.
Complementary strands of research, including the 'Trickle Out Africa' (TOA) Economic and Social Research Council project based in Queen's University Management School, has significantly increased awareness and understanding of social and environmental (SE) enterprises in Sub-Saharan Africa, which is critical to achieving sustainable development and poverty alleviation. The research, by Principal Investigator Dr Diane Holt, has:
This case study is based on a project which guides policy makers and non-governmental organisations (NGOs) in international development policy. `From the Local to the Global' is a project between university academics in the UK and Ireland, academics in the Global South and NGOs. The initiative included the publication of an edited collection of articles on international development in 2009; the establishment of the Policy and Practice journal; the creation of a network of organisations; the integration of the project into a European Union Lifelong Learning project coordinated by the Polska Akcja Humanitarna (PAH) in Warsaw; a book adapted and translated into Slovakian, Polish and Greek; and a lecture tour to 14 universities across Eastern Europe.
The Natural Resources Institute (NRI) of the University of Greenwich has, since the early 1990s, played a lead role in researching, developing and piloting a sustainable and transferable warehouse receipt system (WRS) that is accessible to smallholder farmers in Africa. This institutional innovation helps to overcome post-liberalisation challenges in agriculture by easing access to finance, improving crop marketing and increasing incomes for smallholder farmers. The outcome of the pilots is also influencing strategic choices by governments in developing institutions, regulations and policies which foster efficient and remunerative output markets in Africa.
Malaria kills around 650,000 children a year but can be prevented by killing the mosquito vectors. As mosquitoes become resistant to insecticides the prevention measures can become ineffective. Research at the Liverpool School of Tropical Medicine (LSTM) led by Professor Hemingway FRS has been instrumental in the development of current World Health Organisation (WHO) guidelines to manage resistance, and has led to improved resistance diagnostics and novel monitoring software to integrate entomological and human health outcomes. LSTM's research led to the creation of the Innovative Vector Control Consortium (IVCC) which was established as an independent Product Development Partnership (PDP) in 2008. New, longer lasting formulations of insecticides developed by IVCC are now in operational use, and several novel public health insecticides are under development.
This case study describes a series of research projects undertaken by Professor Hulya Dagdeviren from 2004 to 2012 on issues related to the commercialisation and privatisation of water and sanitation services, which involved changes in the control and management of former public utilities. In particular, it focuses on the findings and impacts of the studies in relation to the access and affordability of these services for poor households in the developing countries. The results of these studies influenced the policy directions of international institutions, especially the UN agencies, which play an important role in funding projects and policy advocacy that ultimately shape the national policies of the developing countries.
LSHTM research has resulted in isoniazid preventive therapy (IPT) becoming one of the key interventions recommended by WHO to reduce the impact of tuberculosis (TB) among HIV-positive people. As a direct result of the research findings, WHO recommendations now promote wider use of IPT. In addition, barriers to implementation have been overcome, leading to increasing worldwide use of IPT for TB prevention among people with HIV. A companion case study addresses impact on screening for TB amongst such people.
Essex research on developing quantitative indicators for assessing countries' performance on human rights and democracy has informed the work of a number of international organisations. Professor Todd Landman's research has been used by the UN Office of the High Commissioner for Human Rights in its provision of assessment frameworks and by the UN Development Programme in its work on democratic governance and sustainable development. Landman's research on democracy underpins the main resources employed by the inter-governmental organisation, International Institute for Democracy and Electoral Assistance (IDEA), based in Sweden. These resources have been translated into four languages and are used to assess the quality of democracy throughout the world. He also provides training for International IDEA's 150 members of staff on the measurement and assessment of democratic performance.
Communicable diseases are a major health burden in the developing world. Early detection and accurate identification of infectious agents is key to their management. However, the complex procedures and logistics of current diagnostic tests often make them unsuitable for use in developing countries. Two technology platforms have been developed that have led to a new generation of simple and inexpensive rapid tests that can be applied in resource-limited settings. A spinout company was set up to allow translation of these platforms into new products. Three tests (Chlamydia, Hepatitis B and HIV) were launched since 2008, with test kits marketed, allowing patients to receive treatment for infections which would have previously gone unnoticed and untreated. The spinout company has raised >$30 million, of which >$20million is since 2008.