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African Wild Dogs (Lycaon pictus; referred to as `AWDs' hereafter for brevity) have been classed as endangered by the International Union for Conservation of Nature (IUCN) for 22 years. Large, well-managed captive breeding programmes provide a safety net to restore wild populations. However, the management of the AWD population has been difficult owing to an incomplete family record of captive AWDs, which risks introducing genetic disorders caused by inbreeding. A genetically informed management plan developed by University of Glasgow researchers has provided a genetic measure of diversity and establishes a genetically informed pedigree, which is used in the European Endangered Species Programme for African Wild Dogs. This has introduced a more informed means to manage the captive AWD population, to maintain the genetic diversity of the species across the European zoo network (roughly half the world's captive AWD population), with 53 zoos in 16 European countries (and Israel) currently participating.
Professor David Feldman's research has influenced thinking about antisemitism, racism and multiculturalism among a range of organisations and policy makers. Since becoming first director of the Pears Institute for the Study of Antisemitism in 2010, he has shaped its development by pursuing a distinctive course of public engagement, with partners such as the All Party Parliamentary Group Against Antisemitism, underpinned by the insights of his research over two decades. As a result, he and the Pears Institute are recognised as significant forces shaping public discourse and policy thinking on issues related to antisemitism.
The HiLo trial has changed management for patients with well-differentiated thyroid cancer. Patients undergoing radioiodine ablation therapy are now given a low dose of radioactive iodine, which has fewer side effects, compared to the previous (standard) high dose. Also, to prepare patients for ablation they now have recombinant human TSH (thyrotropin alfa), which is associated with a better quality of life before and during ablation. The combination of low dose radioiodine and thyrotropin alfa means that patients can be treated as outpatients rather than inpatients. This is a more convenient treatment package, reducing health service and societal costs.
Language impairment is common in children and, without effective early intervention, presents a risk for educational, social and emotional disturbance. The team used their considerable experience in child language research to produce a novel assessment of child language development — The Reynell Developmental Language Scales 3 (RDLS3) — the first test of child language development to be standardised in the U.K. to assess both understanding and production of language in young children. Use of the test has improved language assessment and diagnosis for children with language impairments and, as such, has enabled health and education professionals to target therapy and monitor the effectiveness of interventions to improve child language development. The test has been widely used in the U.K. and is now also being used widely internationally. Recent research by the team has informed a revised version of the test — The New Reynell Developmental Language Scales (NRDLS). Sales figures of the RDLS3 and the commissioning of the NRDLS are testament to its outstanding reputation and enduring legacy worldwide.
Researchers at the University of Leeds (UoL) have identified mutations in key genes which are major causes of deafness and blindness. Mutations in GJB2, identified in a Leeds/London collaboration, are the most common cause of human inherited deafness, affecting millions worldwide, and Leeds researchers have also highlighted 13 key genes involved in inherited blindness, accounting for an estimated 5% of around 2 million people throughout the world with inherited eye diseases. This work has led to the availability of vital genetic testing, enabling early diagnosis, better management and improving outcomes for patients, as well as better counselling and prenatal screening for families.
This case study focuses on the Israeli-Palestinian water conflict within the context of the Oslo peace process. It documents four areas of impact, the underpinning research and associated engagement and dissemination activity having: (1) [text removed for publication] (2) significantly enhanced public and policy understanding of, and debate on, the Israeli-Palestinian water conflict, within Israel, the Palestinian territories and internationally; (3) [text removed for publication] and (4) contributed to the emergence of influential critiques of international policy on water `cooperation'.
Havi Carel's work on the experience of illness has had wide-ranging and significant impact on health professionals, patients and their families, policy makers and health researchers throughout the world. Her influential book, Illness, sparked a public debate on the importance of the first-person experience of illness. Consequently, through presentations, media coverage, public debates, academic-practitioner networks, educational activities and public workshops, Carel's influence on many people's perceptions of illness has been profound.
Hughes' impact arises from his music for films without sound, which has rendered historically important silent films, and more recent silent film formats, accessible to contemporary audiences. Critics, programmers and broadcasters have all recognised this impact in their commissions and programming of Hughes' scores, and Hughes' work has also impacted upon the way in which museum curators display film and other archival materials. The films include commercial DVD releases of classic silent films by Sergei Eisenstein and Yasujiro Ozu, music for Joris Ivens' film Regen (1929), music for a new film by photographer Sophie Rickett, and music for a documentary image sequence of photographs from the Imperial War Museum archive.
New criteria for the diagnosis of diabetes in pregnancy have been developed by the International Association of Diabetes in Pregnancy Study Groups and adopted by the American Diabetes Association on the basis of the Hyperglycaemia and Pregnancy Outcomes (HAPO) study. These new criteria double the percentage of women diagnosed with diabetes in pregnancy from approximately 8.5% to 17%. Appropriate management improves outcomes for them and their new born children. The results, which proved valid for all ethnic groups and countries, have led to a worldwide re-appraisal of glycaemic risk in pregnancy and the introduction of new guidelines to manage this.
Chemtrix Ltd. was established in February 2006 as a 50-50 joint venture between the University of Hull and Lionix Ltd. In 2008 the company attracted investment from Limburg Ventures BV, Panthera, Technostartersfund, Microfix BV and Hugo Delissen (€2 million) that led to the creation of Chemtrix BV. In 2009 the Company launched Chemtrix USA and a second investment round followed with investors Particon BV. In 2012 ESK Ceramics GmbH & Co. KG, acquired a minority interest (30%) in Chemtrix BV based on a valuation of €5.3 million.
The three products developed and marketed by Chemtix, Labtrix®, KiloFlow® and Plantrix®, are differentiated from competitor products as they offer `scalable flow chemistry', such that optimised reaction conditions can be easily scaled from R&D to production. In addition to the employees and investors in Chemtrix the main non-academic beneficiaries of the research have been industrial customers such as Janssen Pharmaceutica NV, Edward Air Force Base, Iolitec GmbH and DSM.