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Development of the human cell GADD45a assay enabled accurate identification of carcinogens in vitro, with a low rate of misleading positives. Through the spin-out company Gentronix, this research is reducing costs to industry and decreasing the use of animals in research. Industrial collaboration has enabled commercial adoption of the technology in many sectors. With a 10-fold increase in orders in 2012 versus 2008, Gentronix is a profitable business employing 17 people and with an annual turnover of £1.88m. During 2008-12, Gentronix released a series of new products, established testing services, and signed a product license agreement with GlaxoSmithKline. More than 100 companies worldwide are using Gentronix kits, including pharmaceutical, agricultural and health and beauty companies, along with manufacturers of food flavourings and household goods. The Gentronix assay is currently being reviewed by the European Centre for the Validation of Alternative Methods.
Research at Lancaster led to a novel approach to detect the source of cases of campylobacteriosis (a bacterial foodborne disease). The application of this method to data from New Zealand pin- pointed that New-Zealand's high rate of cases was linked to the eating of contaminated poultry. These results were a key part of the evidence used by New Zealand's Food Safety Authority to introduce a new code of practice for the poultry industry. The impact of this code of practice has been a halving of the number of reported cases of campylobacteriosis in New Zealand (from around 16,000 cases in 2006 to less than 7,000 in 2008). With notification rates estimated as 1 in 10, this corresponds to around 90,000 fewer actual cases per year. The saving for the New Zealand economy during the REF census period has been independently estimated as between £100M and £150M.
Our research on Active Shape Models (ASMs) and Active Appearance Models (AAMs) opened up a radically new approach to automated image interpretation, with applications in industrial inspection, medical image analysis, and face tracking/recognition. We identify:
Augmented reality (AR) and physiological computing (PC) represent computing paradigms for wearable technology. Both forms may be combined to deliver Adaptive AR (A2R) where changes in psychophysiology are used to adapt digital artifacts in real-time. A number of art exhibits were created that represented A2R and were presented to the public as part of the Turning FACT Inside Out show in Liverpool. The impact of this research is evidenced by: (a) engaging the public with emerging technology, (b) influencing the strategy of an arts organisation, and (c) informing the practice of artists.
Over a decade's research by Introna and Hayes has investigated the biases inherent in automated systems. As part of this research they showed that the design and use of plagiarism detection systems (PDS), used by Higher Education Institutions (HEIs) worldwide, may be unfair due to their embedded values and assumptions. A series of reports, workshops and supporting resources, using these insights, have transformed writing support and teaching practices at no less than 32 HEIs nationally and internationally, affecting lecturers, support staff and student union representatives. As a result, at least 10 HEIs have developed less punitive policy frameworks and taken a more developmental approach, leading to a much fairer treatment of plagiarism cases.
Research conducted by the University of Liverpool (UoL) has convincingly shown that there are strong links between the exposure of children to food advertising, brand recognition and being overweight or obese. This work consistently informs the policies of regulators and health agencies, nationally and internationally. In this specific example, work by Halford and Boyland to characterize the effects of food advertising on children's diet, food preferences, intake and body weight has had a direct effect on UK and overseas policy development. Notably this includes informing WHO guidelines to national governments on introducing effective regulatory frameworks and for monitoring their effectiveness.
This case is based on economic impact. It shows how research by Professor Michael Wooldridge at the University of Liverpool on the Gaia Methodology for agent-oriented software engineering improved the performance of the Swiss company Whitestein Technologies AG and of international users of its key product. Specifically, the research enabled Whitestein to develop its business process management system (BPM) Living Systems Process Suite which delivers several million pounds per year of revenues, corresponding to 50% of their total business revenues. Users of Whitestein's Living Systems Process Suite since 2008 include Daimler AG, Transcor Astra Group, Vienna Insurance Group, and the US Department of Veterans Affairs. In 2010 Gartner, the world's leading IT advisory company, recognized the impact and innovation of the Living Systems Process Suite by naming Whitestein a Cool Vendor in BPM.
Research on the historian Herodotus, the history of the Achaemenid Persian empire, and the complex relationship between Greek and Persian worlds in the Classical period has had an impact in two main ways:
A research partnership between Edge Hill University and Sefton Metropolitan Borough Council developed innovative methods of identifying gaps in knowledge and understanding about sedimentary coastal dynamics and investigating practitioner needs. The partnership enabled the dissemination of scientific information to audiences across the wider community. The partnership provided a framework which enabled and enhanced integrated coastal zone management (ICZM). Within this framework coastal zone managers were supported in the development of adaptation and mitigation strategies, taking account of both long and short term environmental change. Policy and management decisions are now based upon sound scientific evidence wherever possible, ascertained by research where time allows, with significant scientific, social and policy benefits. Practice elsewhere on the UK's Irish sea coast, and elsewhere in the EU, has been influenced.
Measurement of hormones is essential to the understanding and diagnosis of endocrine diseases. White and her research group have developed unique antibodies that are widely used in diagnostic assays for adrenocorticotrophic hormone (ACTH) and related peptides, including the first and only kit for measuring pro-opiomelanocortin (POMC), the precursor of ACTH. These assays are used worldwide for diagnosis, decisions on treatment, monitoring for recurrence of tumours and prognosis in a number of patient groups with life-threatening endocrine disorders. Global sales of the ACTH Elecsys tests by Roche exceeded 6 million kits since 2008. AstraZeneca has used the POMC and ACTH assays in its drug discovery programmes in the cardiovascular and metabolic diseases therapy area. The antibodies therefore have had health impact in relieving suffering and in improving patient care, as well as commercial impact in worldwide sales of assays and influencing drug development strategies.