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Professor Paul Grout has had a significant impact on national policy on the delivery of public services by the private sector in the last five years. His research undertaken at the University of Bristol on private provision by regulated utility companies and public private partnerships, using both economic theory and empirical studies, paved the way for his central involvement in, and directly informed, key regulatory decisions. These decisions impact materially on almost every individual and organisation in the UK. His research also directly led to his appointment in 2012 to the Board of Ofgem (the Gas and Electricity Markets Authority), the UK energy regulator.
Defra-funded research at the University of Bristol showed that the water bath stunning protocols commonly used in commercial processing plants resulted in paralysis rather than unconsciousness in chickens during slaughter. This finding led directly to the modification of stunning protocols in a European Union Regulation (1099/2009). Their practical application within slaughter plants has been promoted to the poultry industry in Europe and worldwide via Animal Welfare Officer (AWO) training courses that were developed in Bristol. This has ensured that since 1st January 2013 billions of birds in Europe are now adequately stunned, and therefore unconscious, before they are slaughtered.
Non-Destructive Testing (NDT) is essential for the safe and efficient operation of high-value engineering plant in many engineering sectors. Research into ultrasonic arrays at the University of Bristol has had a major impact on NDT. Exploitation of the techniques developed has directly led to combined sales of around [text removed for publication]. For major end-users of NDT such as Ontario Power Generation, BAE Systems and Rolls-Royce, the research is leading to reductions in inspection costs, [text removed for publication]. In addition, highly-skilled engineers have been trained through an Engineering Doctorate programme and are now leading the industrial development of new array inspections based on underlying research performed at Bristol.
An artificial cervical joint, designed by Mr Steven Gill, honorary Chair in the University of Bristol and consultant in Neurosurgery at Frenchay Hospital, is widely used for the treatment of degenerative cervical disc disease. Patients who have received the device have retained neck mobility and have experienced less neck pain and better neurological function than patients who have undergone conventional treatment involving fusion of the vertebrae. The device has also yielded substantial long-term savings as far fewer patients require secondary surgery. Gill's device was the first artificial cervical joint approved by the US Food and Drug Administration (FDA), in 2007. In early 2008, the global medical technology company Medtronic launched the device commercially in the US. The device is now used in 60 countries and has so far generated more than $137 million in sales.
Research at the University of Bristol (UoB) led to the Department of Health (DH) decision in 1997 that screening for prostate cancer would not be introduced in the UK until there was evidence that benefits outweighed harms. UoB-led and collaborative research subsequently provided evidence to support informed decision-making in the NHS. A formal review by the DH in 2010 endorsed the policy and confirmed that any change would be based on evidence from the team's randomised trials. This research has ensured UK men have avoided known harms of prostate cancer screening in the context of uncertain benefits, and saved the UK economy £ billions.
Research on clinically important red blood cell membrane proteins has helped avoid unnecessary treatment of Rhesus negative pregnant women and enabled the early diagnosis of a rare kidney disease. During the late 1990s, researchers at the University of Bristol, in collaboration with the Blood Service in Bristol, cloned, sequenced and characterised many red blood cell membrane proteins important for transfusion, including the Rhesus proteins and Band 3/AE1 (SLC4AE1 gene). The work on Rhesus proteins facilitated the use of less invasive genetic screening methods to ascertain whether treatment was required to avoid Haemolytic Disease of the Foetus or Newborn (HDFN). In the UK, 5,000 women have been screened since 2001. Within the first six months of implementation of a Danish national screening program in January 2010, 862 women avoided unnecessary treatment. Reducing unnecessary treatment of mothers has saved resources and avoided unnecessary exposure to human derived blood products. In addition, research that has identified specific SLC4AE1 gene mutations that cause the rare kidney disease called distal renal tubular acidosis has enabled the early diagnosis and treatment of the disease, resulting in improved outcomes for patients.
UK and international comparative research on socioeconomic inequality in early childhood, conducted by University of Bristol in conjunction with international colleagues, has profoundly influenced a variety of UK policy initiatives since 2010. Reliable evidence on the extent of learning deficits among recent cohorts of socio-economically disadvantaged children in early childhood has led to widespread acceptance in government that policy to promote equality of opportunity must begin in the preschool period. Analysis of the factors underpinning the disparities has led to and informed the development of official UK indicators to monitor progress in this area and specific policies to support parents, with outstanding potential to impact positively on the life chances of disadvantaged children. These include, for example, free childcare places for disadvantaged two-year-olds, an increased number of health visitors and the launch of telephone and online services for parents.
Researchers at the University of Bristol's Interface Analysis Centre played a key role in making it possible to extend the life of two nuclear power stations. Their insights into how the microstructure of reactor-core graphite degrades during service and how the material fractures enabled Magnox Ltd to construct a convincing safety case for Oldbury nuclear power station to operate for an extra four years and Wylfa power station to run for an additional four to six years. In terms of the value of the electricity generated, these extensions are worth some £5 billion. In addition, the longer lifespan of these low-carbon power sources means that less energy has to be generated from other, high-carbon sources, with the environmental benefit of an overall reduction in CO2 emissions.
Research carried out in the School of Mathematics at the University of Bristol between 1998 and 2005 has been instrumental in the development of structures that arrest or deflect the rapid flow of snow that characterises avalanches in mountainous regions of the world. The research has been embodied in a series of guidance documents for engineers on the design of such structures and many defence dams and barriers have been built across Europe since 2008. The guidance is now adopted as standard practice in many of the countries that experience avalanches. Investment in avalanche defence projects based on the design principles set out in the guidance runs into tens of millions of pounds. The Bristol research is also used internationally in the training of engineers who specialise in avalanche protection schemes. Given the scale of the threat to life and property from these potent natural hazards, the impact of the research is considerable in terms of the societal and economic benefits derived from the reduction of the risk posed by snow avalanches.
Hundreds of school students, their teachers, local heritage groups, audiences at live events and thousands of people engaging in online activities have benefited from a University of Bristol research project called Resurrecting the Past: Virtual Antiquities in the Nineteenth Century. The project uses the medium of a 3D online model of the Pompeian Court of the Crystal Palace to promote awareness of the Palace and provide access to knowledge about it. Just as significantly, the project has explored how history is interpreted and inspired innovative ways of teaching. The research has not only illuminated a particular place and period but also investigated the relationships between 19th-century physical and 21st-century virtual reconstruction. Perhaps most importantly, it has given young people a deeper, transferable understanding of the nature of history and historical `facts'.