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The `rodent attentional set-shifting task' provides a novel method for assessing cognitive impairments in rodents that are directly equivalent to those seen in several psychiatric and neurological disorders. The research has had significant and broad impact on commerce, as evidenced by: i) commercial adoption of a new process across the pharmaceutical industry through use of the task in pre-clinical testing of putative therapeutic compounds and inclusion of the task in NIMH-sponsored guidelines for schizophrenia clinical trials; and ii) demonstrable collaborations with industry, including a Royal Society Industry fellowship, CASE studentships and academic research contracts.
Impact:
The underpinning research was exploited to design an exceptionally efficient Real-Time Operating System (RTOS), used in automotive Electronic Control Units (ECUs), and its associated schedulability analysis tools. Since 2008, the RTOS has been deployed in 50 to 55 million new ECUs each year. The RTOS has been standardised upon (used by default in all ECUs) by [text removed for publication]. ([text removed for publication] in terms of world-wide automotive powertrain systems suppliers. [text removed for publication] all rank in the top [text removed for publication] world-wide for chassis electronics). The RTOS is used in cars produced by [text removed for publication] as well as many others. Revenues from the RTOS exceed [text removed for publication] per year.
CANTAB-Paired Associates Learning (PAL) was developed to detect early memory problems in Alzheimer's disease; and was recently (in 2012) launched by Cambridge Cognition (floated on the London Stock Exchange in April 2013) as a mobile (iPad) application (CANTABmobile™) suitable for use in GP clinics. This and other cognitive tests from the CANTAB battery have also been employed in 77 clinical trials since 2008, involving hundreds of sites world-wide, by most of the major pharmaceutical companies and by biotech, device and nutraceutical companies. CANTABmobile™ currently has 166 licensed user-practitioners including six clinical commissioning groups implementing the national initiative for early diagnosis.
The volume and diversity of data that companies need to handle are increasing exponentially. In order to compete effectively and ensure companies' commercial sustainability, it is becoming crucial to achieve robust traceability in both their data and the evolving designs of their systems. The CRISTAL software addresses this. It was originally developed at CERN, with substantial contributions from UWE Bristol, for one of the Large Hadron Collider (LHC) experiments, and has been transferred into the commercial world. Companies have been able to demonstrate increased agility, generate additional revenue, and improve the efficiency and cost-effectiveness with which they develop and implement systems in various areas, including business process management (BPM), healthcare and accounting applications. CRISTAL's ability to manage data and their provenance at the terabyte scale, with full traceability over extended timescales, based on its description-driven approach, has provided the adaptability required to future proof dynamically evolving software for these businesses.
This case study embodies a non-linear relationship between underpinning research, software development and deployment. It involves computer science research at UWE in conjunction with its applied development for the world's largest particle physics laboratory and onward deployment commercially into private sector industry.
We have established a primate research centre (The Macaque Study Centre) in a zoo environment (Marwell Zoo) for research into primate social cognition. Visitors can watch the science taking place, which 1) significantly increases their perception of the zoo as a place of learning, 2) increases their knowledge about the specific research being conducted, and 3) improves children's attitudes to science as an exciting subject. Marwell Zoo integrate the research into their educational workshops, and similar facilities are now being established in other zoos in light of the demonstrable scientific, public engagement/involvement and animal welfare benefits.
The mouse is the most important laboratory animal used worldwide in biomedical research and for regulatory testing of products. Research at the University of Liverpool by Prof Hurst has led to a change in the methods universally recommended for routine handling of mice to minimize a well- recognized problem that handling can create high anxiety, stress and a risk of animals biting the handler. This has impacts for animal welfare, for practitioners, and for reliability in a broad range of research and testing using mice (e.g. in the pharmaceuticals industry) where responses can be confounded by uncontrolled anxiety responses. Mouse handling guidelines have been changed and are being implemented in animal research facilities.
The GRANIT system is a non-destructive technique for assessing the condition of rock bolts and ground anchors used to support structures such as tunnels. It applies a small impulse to the bolt and interprets the resulting vibration response to provide estimates of load and unbonded length. Initial development of the system was based on the findings of EPSRC projects in tunnels undertaken by the Universities of Aberdeen and Bradford from 1989-1997, resulting in an empirically based method. However, research undertaken at the University of Aberdeen since 1998 has provided the understanding of the process and developed the fundamental engineering science needed to underpin the development of a full commercial system. The GRANIT system is patented, and has been subject to worldwide licence to Halcrow who have undertaken testing and provided a method of ensuring the safety of mines, tunnels and similar structures. Halcrow received the NCE award for Technical Innovation Award for GRANIT in December 2010. The impact of the research has been in part economic, but largely on practitioners and professional services.
Using powertrain system models arising from QUB research Wrightbus Ltd developed an advanced eco-friendly hybrid diesel-electric bus which won the New Bus for London contract worth £230M supplying 600 buses to Transport for London (commencing August 2012).
Demonstrating highly significant economic and environmental impacts the bus has twice the fuel economy of a standard diesel and emits less than half the CO2 and NOx. The full fleet reduces annual CO2 emissions in London by 230,000 tonnes, improving air quality and reducing greenhouse gases.
The company continues to develop the technology in new hybrid vehicles reaching worldwide, including USA, Hong Kong, Singapore and China.
Collaboration between the University of Southampton and scientists at GlaxoSmithKline (GSK) has resulted in the adoption of new statistical design of experiments and modelling methods for the confirmation of a robust operating region for the industrial production of new drugs. These methods have enabled larger numbers of factors to be investigated simultaneously than previously possible, improving scientific understanding of the chemical processes and producing savings of time, money and effort. Southampton's new methods were used in a key process required for the registration of a new skin cancer drug with the US Food and Drug Administration, where the research enabled the verification of a robust operating region to be completed in a third of the previous time.
Research into variable mechanical energy absorption, using Finite Element (FE) modelling and analysis, funded by Cellbond Ltd., led to a design specification for an Offset Deformable Barrier (ODB). Such barriers are used within the motor manufacturing industry to test vehicular safety. Based on the findings of our research, the barrier used in car crash tests has been redesigned. The design specification for the barrier has been adopted by the European New Car Assessment Programme (EuroNCAP). All newly designed cars are tested with this type of barrier before they enter production. The use of FE modelling and virtual crash testing allows barriers to be designed with particular properties and for the crash testing cycle to be shortened.