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Research using novel techniques of genetic marker-aided selection enabled the development of new high yield, disease- and drought-resistant pearl millet hybrids, of which HHB67-Improved was released throughout India. HHB67-Improved is the first product of marker-assisted breeding to reach cereal producers in India and has spread rapidly since its release, preventing yield losses to downy mildew of up to 30% (valued at £7.8M) per year, and providing £2.6M additional annual grain yield. By 2011, it was grown on over 700,000 ha and currently three million people have improved food security as a direct result of this international development focused work.
Our research has led to increased crop yields and a reduction in the need for synthetic pesticides, through a new patented technology of treating seed with the natural plant signalling molecule, jasmonic acid. Lancaster's fundamental research in to the biology of plant-herbivore interactions showed for the first time that jasmonic acid (JA) seed treatment of a range of crops improved pest resistance for many weeks after germination, without the physiological costs of foliar JA application. We have patented this JA seed treatment technology (patents awarded in USA, Canada, Japan, Europe, Australia, New Zealand, and Mexico, applied for in three other major countries) and licensed it to BASF (previously Becker Underwood). JA seed treatments have been available to growers in the USA since 2010, and the technology is being rolled-out internationally for a range of major global crops.
Reliable seed performance is the cornerstone of crop establishment, an important trait that determines the cost and resource efficiency of crop production. In practice, seed performance varies, and this creates a substantial global problem for seed producers and farmers. From 1980 until the present time, Finch-Savage and Rowse have provided knowledge, patented techniques and genetic backgrounds from their research programmes to enhance the performance of seeds in crop production. Seed production businesses worldwide use and continue to adopt these techniques. These include both national (e.g. Elsoms Seeds, UK; Seed Enhancements, New Zealand) and global (e.g. Syngenta and Bayer) companies. Therefore, the work of Finch-Savage and Rowse has had, and continues to have, a direct impact on food security, sustainable crop production and the profitability of farming and seed production businesses.
Research and knowledge dissemination led by Greenwich on biological pesticides has made a major contribution to the introduction of novel safe commercial pesticides based on insect viruses to help farmers overcome the problems of chemical resistance in major crop pests in Asia and Africa. Research at Greenwich identified effective virus strains, methods of production and formulation which were then developed and evaluated with in country research collaborators before being transferred to local SMEs to start up production in India, Thailand, Kenya and Tanzania. Greenwich advised governments on adopting suitable regulation to support the registration and sale of these novel pesticides.
Strategies have been developed to combat two fungal diseases that can devastate production of palm oil, a world commodity supplying 40% of world vegetable oil and valued at $46 Bn (USD):
(i) A novel fungicide treatment was designed to eradicate from seeds Fusarium, a lethal fungal pathogen in Africa (responsible for yield losses of up to 54% prior to death of infected palms), and prevent inter-continental disease spread.
(ii) Improved disease resistance screening for Ganoderma, the second major pathogen, found in South East Asia and responsible for estimated losses of £2Bn per annum in Malaysia alone, continues to identify disease-resistant lines for cultivation. Through collaborative projects, these strategies have been adopted as industry standards in Ghana, Congo, Malaysia and Indonesia. These sustainable approaches to disease control provide increased turnover and sales, and enhance food security at both local and international levels.
Weak acids (e.g. sorbic acid) are used by food manufacturers to prevent fungal contamination of food and beverages. Professor Archer in the Molecular Microbiology group determined the fungal species that cause such contamination, and identified fungal genes and enzymes that confer resistance to sorbic acid during initial outgrowth of fungal spores. They characterised the biochemistry of the resistance mechanism, enabling design of improved mould inhibitors. These inhibitors, used at the correct time, have improved manufacturing processes to prevent mould contamination and product wastage. Knowledge of mould genetics has also been applied to other industries to improve food additive and biofuel manufacturing processes.
University of Nottingham (UoN) research into optimum plant populations and lodging in wheat has led to advances in agronomic practices for winter wheat in the UK, in particular changes in the way that seed rates are calculated (by number, rather than weight) to establish optimum plant populations. Most significantly, growers and agronomists now have an improved understanding of the crop characteristics that affect wheat lodging risk and have made changes to crop management to minimise the problem. This has led to reduced incidence of lodging in the UK, thereby protecting yield and quality of UK's most important arable crop.
Local authorities, the UK government and the European Commission have benefitted from the widespread application of new molecular methodologies, developed in 2005 and applied by the University of Reading's Vertebrate Pests Unit (VPU) to identify and quantify anticoagulant rodenticide resistance in rodent populations. Rodents are a major global pest that consumes our food, causes contamination with urine and faeces, damages structures through gnawing, transmits diseases, and impacts on species of conservation concern. Due to historical success and recent regulatory restrictions, anticoagulant rodenticides are the most common control method for these pests. However, physiological resistance to anticoagulants is now widespread and the VPU has been involved in mapping this resistance and identifying the genetic basis for the resistance. Their research has led to new methodologies to identify anticoagulant resistance that have been adopted by the global plant science industry and to new guidance in treating resistant populations that has been adopted by the European biocides industry.
Research over the last 20 years by Jane Nicklin (née Faull) and her research group has established expertise in fungi, which has led to impacts in three areas: impacts on the licensing of commercial products for the control of insect pests which affect food crops, which have led to a new product being licensed in the US to the benefit of vine growers; impacts on heritage conservation, where the work has benefitted English Heritage, the National Trust and many other conservation groups; and impacts on public awareness and media engagement with science, in particular through her work with Channel 4's How Clean is your House? in 2009.
Carotenoids (e.g. β-carotene, provitamin A) are antioxidants which are essential in the human diet and which reduce the onset of chronic diseases. Research in the unit on the carotenoid pathway has provided the tools and strategies to deliver foods with increased levels of nutritional carotenoids. This has led to the production of novel food supplements and to Golden Rice (GR), a humanitarian product aimed at alleviating Vitamin A deficiency in the developing world. Field and intervention trials have shown that GR is effective and its production feasible. The research has led to beneficial impacts on health and welfare, international development, commerce, public understanding and education.