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Fluorescence lifetime research since 1993 in Strathclyde's Photophysics Group led by Prof. David Birch contributed to the success of the University spin-out company IBH (Imhof, Birch, Hallam), and its successful merger with the £1Bn multinational company Horiba. The Strathclyde research has helped Horiba to be, since 2008, the market-leading supplier of fluorescence spectrometers, which comprise steady-state, lifetime and hybrid instruments. The commercial success of the company has led to economic benefits and employment. Through production of an improved spectrometry product range, the Strathclyde research has also facilitated multidisciplinary molecular and materials research globally, across Industry, Government and University sectors, bringing benefits to diverse disciplines such as life sciences, healthcare, chemistry, and nanotechnology.
Imperial researchers in Prof Paul French's photonics group demonstrated one of the first practical FLIM instruments in 1997 using a prototype gated optical intensifier (GOI) developed by Kentech Instruments Ltd and a home-built solid-state ultrafast laser. They subsequently pioneered the use of ultrafast supercontinuum sources (USS) for FLIM. Today wide-field time-gated FLIM is a commercial success and is being widely applied for biomedicine, including for imaging of diseased tissue [e.g. 5] and for FRET (Fluorescence resonance energy transfer) microscopy to assay protein interactions [e.g. 3, 4]. This research thus helped translate FLIM to a wider community, highlighting the potential for tissue imaging, cell biology and drug discovery. It stimulated about £5M of GOI sales for Kentech [section 5, source A], with whom they developed time-gated FLIM technology and applications, and millions of pounds worth of sales of supercontinuum sources for Fianium Ltd [B].
Impact: Commerce and professional services; the development of Optical Projection Tomography (OPT) — a technique for three-dimensional (3D) optical microscopy.
Significance: A step-change in scientific imaging; novel equipment and training services for imaging laboratories, offering a new standard in 3D microscopy. Over £2M in sales for the MRC.
Beneficiaries: Scientific institutions and imaging facilities, commerce.
Attribution: OPT was developed, by Sharpe, Baldock and Davidson, and commercialised at the MRC Human Genetics Unit, UoE.
Reach: World-wide: OPT instruments are used in Europe, America, Asia and Australia; chapters on OPT can be found in major microscopy textbooks.
The sale of Genapta Ltd. to a North American Instrument manufacturer was successfully completed in December 2008, with the release of the holdback payments and associated validation of its technology, as well as the transfer of know-how to the purchaser. The funds from the sale also benefitted the shareholders, including Cambridge Enterprise Ltd which was able to reinvest funds in new University spin-outs. Genapta was co-founded by David Richards, with product development between 2001 and 2008 of a fluorescence assay system for biochemical screening informed by his expertise in fluorescence detection, resulting from his research during this period.
Imaging speed is of critical importance in most Magnetic Resonance (MR) imaging applications. King's College London (KCL) researchers have developed spatiotemporal undersamplings, or "k-t" methods, for three-dimensional (3D) imaging and corresponding image reconstruction methods that have increased the speed of imaging significantly, so that particular scans are now 5-7 fold faster. This has directly impacted the experience of the patient whose overall examination time has been reduced from more than 1 hour to less than 30 minutes depending on the application. The technology has been patented and has been implemented by Philips Healthcare, one of the three major manufacturers of MR equipment. A clinical solution platform for 3D MR cardiac perfusion and quantitative flow imaging, based on the technology developed at KCL, has also been launched by the Swiss company, GyroTools LLC.
Diabetic retinopathy is a leading cause of blindness in people of working age. Screening programmes for its early detection are therefore crucial. Following the introduction of screening programmes for diabetic eye disease, research carried out at the University of Aberdeen enabled the resulting images to be analysed by computer rather than manually, a technique that has now been adopted by Scotland's national screening programme. This has achieved a significant impact on patient health, as well as economic impacts for the taxpayer, through cost savings, and for the company that developed the screening software commercially.
Therefore this research has had impact in health and welfare by influencing decisions and care practices by a health service.
danceroom Spectroscopy (dS) is a cutting-edge, interactive public engagement project that allows people to literally step into an interactive molecular dynamics simulation. It has its origins in fundamental research carried out to understand ultrafast chemical dynamics in liquids. On a large scale, dS impact has arisen from its deployment in premier cultural settings in the UK and internationally, eg the London 2012 Olympics, London's Barbican Arts Centre, Ars Electronica (Austria), ZKM (Germany), and the World Science Festival (New York City). Statistics indicate well over 60,000 people have so far experienced dS, with audiences spanning ages from 3 to 73, and attracting those with a variety of interests including science, technology, art and education. Within the cultural and media sectors, dS has received several awards and substantial press attention, all of which has proven beneficial to several non-academic collaborators and partner institutions. The substantial momentum and opportunities available from dS are also being commercially exploited through a spin-out company called Interactive Scientific Ltd.
Since the 1990s, the threat from malevolent release of airborne pathogens has grown in military and civilian contexts. However, solid-state UV lasers, central to the preferred fluorescence detection technologies, were prohibitively expensive for use in `low-cost' detectors. In 2001, Hertfordshire researchers proposed an alternative based on inexpensive xenon flashlamp sources, commonly used in disposable cameras. Between 2001 and 2006, they developed and optimised this approach, with the resulting `WIBS' technology now a core part of the UK military's bioaerosol defence programme and patented worldwide. The technology's affordability also has led to its growing international use in areas such as atmospheric science, climate research, and occupational health. In 2012, a commercial licence was purchased by a leading US instrumentation company to exploit in the field of atmospheric and climate science; discussions with further licensees to exploit in other fields are continuing.
Positron emission tomography (PET) and magnetic resonance imaging (MRI) are two of the most powerful clinical imaging tools. They provide complementary information that is used in the diagnosis of many diseases and in assessing the effect of current and new therapies. Researchers at King's College London, in an international collaboration, demonstrated for the first time the simultaneous acquisition of PET and MR data and the application of the technique in preclinical models. Simultaneous PET-MR systems significantly improve the quality of patient care by allowing both PET and MR examinations to be performed in a single scanning session and by reducing radiation exposure by a factor of two. This pioneering work has led to clinical whole body simultaneous PET-MR systems recently becoming commercially available and there are currently around 40 PET-MR scanners installed in clinical/research institutions worldwide.
The Sensing & Imaging Group at Manchester Metropolitan has developed novel, effective non-imaging radar methods for the stand-off screening of people for concealed threat items. Some of this technology is at a high Technology Readiness Level (TRL) and has undergone rigorous independent trials. The results of these trials and of other published work by the group has informed UK Government strategy in effective methods of people screening at standoff distances, created a product which is entering production, and data which are used in the design of effective simulants for testing threat scenarios. This will save lives, deter and stop gun crime and prevent damage to key infrastructure when deployed in sensitive areas likely to be targeted by terrorist action.