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Research by Dr Andrew Martin at the UCL Research Department of Structural & Molecular Biology has led to a series of antibody-related tools being made available for free use over the Web. One of these, Abysis, has been visited over 360,000 times by over 8,000 users. Abysis has also been released under a commercial license and has been purchased by companies ranging from small biotechs to large pharma for use in their antibody therapeutic development pipelines, allowing them to identify unusual features of their sequences and to improve strategies for humanisation. Martin has also acted as an expert witness for drug companies in patent disputes.
Research led by the School of Geography at the University of Leeds has enabled, for the first time, the use of on-the-ground observations to evaluate directly the role of tropical forests in the global carbon cycle and to assess their sensitivity to change. Findings from the research have had a significant impact on international debates on the future trajectory of climate change and appropriate policy responses, and are influencing national-scale efforts across the tropics to manage forests in the face of climate change and to reduce carbon emissions resulting from deforestation [D, E, G, H, J]. The success of this Leeds-led initiative has been achieved through the extensive network of scientists involved in this global forest observatory: more than 250 scientists from over 50 institutions across more than 30 countries are now involved.
Through active engagement in policy processes, systems research at Lincoln produced a sustained change in governmental and third sector approaches to citizenship education and hence citizen participation. Translating and refining the initial concepts, a network of Third Sector organisations and universities (including the researchers) ran successful pilot projects to benefit more than 1,300 people. This led to the inclusion of the `Take Part' concept in three government White Papers. Pathways to impact were two national learning frameworks, an £8.7 million programme (2009-2011), and a £0.77m capacity building cluster (2008-2013). The programme reached over 18,000 people nationally, who became more effectively involved in local democracy.
Wells' research on corporate liability led to direct changes to UK law in the Bribery Act 2010 and has begun to have significant impact internationally. UK law now complies with the 1997 OECD Anti-Bribery Convention. Significant changes were made after Parliamentary scrutiny of the draft Bill, as a result of Wells' intervention, which have a major effect on all corporations, including multinationals, demonstrating the international reach and significance of this law. Her work has had further international reach and significance on the development of the OECD's Anti-Corruption Initiative and on the International Bar Association's Task Force (IBAHRI) on Tax Havens, Poverty and Human Rights.
Essex research on understanding the vulnerability of displaced persons has changed the practice of organisations that work with asylum seekers and refugees. Professor Renos Papadopoulos' research has focused on the resilience and strengths of the individual, rather than seeing him/her as a passive `victim'. This approach has informed two instruments that are used to assess vulnerability: the Trauma Grid and ASPIS. These instruments have been adopted by a number of organisations throughout the world and Papadopoulos has produced a training manual and provided training programmes for frontline and management staff. The examples provided here document his work with organisations based in the UK, Greece, Colombia and Sudan.
Preziosi and his research group have taken a leading role in conducting biodiversity research in the Ecuadorian Amazon, working in collaboration with national and local governments and indigenous communities. It is critical to monitor and conserve biodiversity in the Ecuadorian Amazon and preserve this unique habitat for local, national and international benefit. Preziosi's research group have demonstrated that indigenous people can be trained to monitor biodiversity accurately. The impact of introducing these new skills to local people in the Payamino community is that they have been empowered to locally monitor and adaptively manage their own resources. By educating local people about the importance of biodiversity, Preziosi's research group have changed the behaviours and attitudes of the community, leading to reduced participation in environmentally harmful practices.
Newcastle University research has made significant contributions to international best practice guidelines used to restore coral reefs. Coral reefs are the most biologically diverse eco-systems on earth, directly and indirectly providing an estimated $375 billion per year in ecosystem services. Despite their importance, very little work had been undertaken to assess the strategies used to rehabilitate damaged reefs prior to the Newcastle research. Research findings have subsequently been incorporated into international best practice guidelines which are used by a diverse group of users including reef managers who use them to plan more ecologically robust reefs and maritime insurers who use them to assess insurance claims related to reef damage by grounded ships.
Research on mediation practice and conflict regulation contributed to the development of resources to enhance professional training standards and democratic participation in conflict-ridden societies. The researchers' work has focused on: a) post-genocide diaspora groups emphasizing the transformative effects of new social networking facilities; b) professional standards in conflict resolution practice; and c) power-sharing arrangements addressing gaps in minority-group representation. Scholarly work on conflict resolution capacity has had an impact on intergovernmental bodies, the media and transnational communities and has demonstrably produced innovative training methods for NGOs and conflict practitioners as well as resources to safeguard inclusivity in divided societies.
The National Institute for health Care Excellence (NICE) in England and Wales makes timely and equitable decisions regarding the use of health technologies (medical devices and pharmaceuticals) within the NHS in order to improve patient care. Such decisions are reliant on Health Technology Assessment (HTA) — the processes of evidence generation and synthesis, and the methods that underpin these. Methods pioneered and developed at Leicester over the last 15 years are now used routinely in HTA both by NICE and the pharmaceutical industry and healthcare consultancy companies who make submissions to NICE. Internationally, these methods are also now being adopted in the US by Agency for Healthcare Research and Quality (AHRQ), as well as in rapidly developing countries such as Brazil and Colombia.
The impact case study relates to two documentaries, ABC Colombia (2007) and Home Sweet Home (2012). Enrica Colusso's practice-as-research exposes, challenges and critiques social structures and institutions, relations of power, oppression and resistance affecting marginalised communities. Her work prioritises the experience of ordinary people living in difficult times. Through the process of filming, screening and broadcasting of her documentaries, this work has had a direct impact upon the communities she films, on the organizations that support them, and on the audiences that view them. This work has an international reach, and significant impact in the following areas: