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Pre-eclampsia is a major contributor to death and disability in pregnancy. Diagnosis, based on accurate blood pressure (BP)/proteinuria determination, is limited by measurement errors and being late features of the disease. In collaboration with industry, King's College London (KCL) researchers have developed an inexpensive, accurate, simple BP device suitable for rural clinics. This device allows intervention to reduce mortality/morbidity and is currently being rolled out in a Gates Foundation project in Africa and Asia. KCL researchers have also helped the company Alere Inc. with the development of a diagnostically accurate test of placental growth factor (PlGF) in women with suspected pre-eclampsia: Alere Triage®PlGF. This demonstrates high sensitivity, superior to current tests, and following commercialisation is being adopted internationally. Their work is additionally reflected in guidelines of international standards for BP device accuracy.
Although Adam Benjamin's research has greatly influenced contemporary dance in the UK and elsewhere through his development and advocacy of inclusive practice, this case study focuses on his impact on contemporary dance and disability culture in Ethiopia. By introducing integrated practice to Adugna Community Dance Company in Addis Ababa (in which able-bodied and disabled dancers perform together), and continuing to foster its development through his choreographic and mentoring work with its current Artistic Directors, he has helped to transform the lives of individual disabled performers as well as strongly contributing to the socially-driven nature, values and aesthetics of contemporary Ethiopian dance.
Research and knowledge dissemination led by Greenwich on biological pesticides has made a major contribution to the introduction of novel safe commercial pesticides based on insect viruses to help farmers overcome the problems of chemical resistance in major crop pests in Asia and Africa. Research at Greenwich identified effective virus strains, methods of production and formulation which were then developed and evaluated with in country research collaborators before being transferred to local SMEs to start up production in India, Thailand, Kenya and Tanzania. Greenwich advised governments on adopting suitable regulation to support the registration and sale of these novel pesticides.
Research at the Liverpool School of Tropical Medicine (LSTM) has developed a successful approach to the rapid scale-up of HIV Testing and Counselling (HTC) services in high prevalence countries, a vital component of the global HIV response. The model combines comprehensive quality assurance with operational research and has led to HTC expansion in mobile, home and facility-based settings. It has also allowed for responsiveness to local needs leading to post rape care services linked to HTC, services for the deaf and HTC for men who have sex with men (MSM) and other hidden populations in Africa. The global impact of this model is reflected in WHO policy, Ministry of Health HTC guidelines in numerous countries in Africa, the on-going work of an indigenous Kenyan NGO and expansion of HTC through community outreach in the UK.
Vincent Gauci and The Open University (OU) Ecosystems Research Group have demonstrated human influences over exchanges of carbon within vulnerable, temperate and tropical wetland ecosystems, which are the largest source of the powerful greenhouse gas methane to the atmosphere. The group's work showing that acid rain pollution suppresses methane emissions from wetlands has influenced policy in the UK, particularly peatland restoration, where the group has had direct interaction with users. The group's work on carbon balance resulting from deforestation, drainage and fires in the carbon-rich Bornean peat swamp has also informed IPCC methodologies for carbon balance calculations in its 2013 Wetlands Supplement.
Research led by Pardhan has enhanced the healthcare offered to diabetic patients of South Asian origin in the UK and overseas (Pakistan, East Africa). Prevalence of diabetes within this ethnic group is six times higher than in Caucasians. Our research into this group, which demonstrated an increased risk of sight-threatening eye disease and poor engagement with screening/treatment regimes, has impacted upon both patients and healthcare practitioners. Ophthalmologists, general practitioners and other clinicians have used our findings to target various physiological and cultural factors that influence diabetic control and eye health in the South Asian population.
Our research also provided the underpinning data that informed reports commissioned by the Royal National Institute of Blind People (RNIB). These reports demonstrate the increased prevalence of eye problems in patients of South Asian origin, and highlight the barriers that affect patients' access to primary and secondary eye-care across the UK. The reports evaluate the effectiveness of current management, and suggest strategies to improve the eye health of this group of patients.
These reports have led directly to the creation of dedicated community-based eye-care programmes. Funded by the Royal National Institute of Blind People (£400,000) and Innovation, Excellence and Strategic Development Fund (Department of Health), the programmes are designed to reduce diabetic-related complications through improved self care by patients in Bradford and Glasgow, regions that have significant Asian diabetic populations.
We conducted research on the impact of land-use change that has resulted in international action to improve forest management. Our research demonstrated that clearing forests to grow crops for biofuels leads to large carbon emissions. In light of these findings, the UK Government amended its biofuel policy to include mandatory sustainability criteria. Leeds researchers co-established with a number of businesses the charity United Bank of Carbon, resulting in the investment of £1.5 million and the protection of 200,000 hectares of forest. Our research underpinned a forest-based climate mitigation scheme resulting in the investment of an additional £440k in forest protection.
This case study details the impact of a pioneering theoretical approach to English language testing. Recognised as the most influential test validation theory in modern assessment, the socio-cognitive framework, conceived by Weir and O'Sullivan, and operationalized and developed further by O'Sullivan at the University of Roehampton, focuses on three key elements: the test taker (social), the test system (cognitive), and the scoring system (evaluative). This framework is applied to give a meaningful measure of a candidate's performance, appropriate to the underlying traits or abilities being assessed. This research has had a significant impact in two distinct phases: 1) through a series of commissioned projects since 2008, the research has had a significant impact on testing bodies, organisations and test takers internationally, and 2) it has underpinned the development of innovative new business products by a leading international educational and cultural organisation since 2012.
Urban greenspace cools cities and reduces rainfall runoff but these effects have been difficult to quantify. Ennos's research is the first to give realistic figures for the contribution of greenspace and assess its potential to climate-proof cities. Key research findings have furthered the concept of green infrastructure, influenced local and national planning policy [text removed for publication]. Novel mapping tools developed by Ennos have had international impact, including use in the city master plan for Addis Ababa, Ethiopia. Community forests have altered their planting practises as a result of Ennos's research findings.
Cognitive Stimulation Therapy (CST) is an evidence-based, brief, group therapy for people with mild to moderate dementia. It was developed and evaluated by UCL in collaboration with Bangor University. Our research showed significant benefits in cognition and quality of life plus cost-effectiveness. Cognitive Stimulation for people with mild/moderate dementia of all types is recommended by NICE and is now in widespread use across the UK and the rest of the world in a variety of settings including care homes, hospitals and the community. A recent audit by the Memory Services National Accreditation Programme reported that 66% of UK memory clinics surveyed were using CST.