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This longstanding research and development programme on teaching and learning conceptual scientific content has resulted in beneficial impacts on the day-to-day teaching practices of secondary school science teachers within and beyond the UK. The programme has resulted in three broad areas of impact:
Bio Nano Consulting (http://www.bio-nano-consulting.com) was established as an operating business in 2007 through a joint venture between Imperial College London and UCL, whose formation was underpinned by research produced by Professor Tony Cass's group at Imperial. The company is the first consultancy in Europe to focus on the increasingly important intersection between bio- and nanotechnology, and it facilitates the development and commercialisation of new biomedical and nanotechnology-based techniques. Since its start-up, the company has attracted numerous clients across the aerospace and diagnostics sectors, including Lockheed-Martin and [text removed for publication]. The company's activities have generated £6M worth of revenue and it has a growing portfolio. The company, which is based in London, currently has 8 full time employees.
The psycholinguistic framework for research and practice developed by Stackhouse and Wells is now a key component of the majority of UK speech and language therapy courses at undergraduate and postgraduate levels. In addition to influencing the design and delivery of course curricula in the UK, Europe, Australia, South Africa and USA, the framework is used in continuing professional development for speech and language therapists (SLTs), special needs teachers, and with parents. The resultant impact on clinical and educational practice, the assessment of children and the planning of therapy interventions can be seen across the spectrum of persisting speech difficulties, including those related to dyspraxia, dysarthria, dyslexia, cleft palate, Down Syndrome, stammering, specific speech and language impairments.
Research into the biocompatibility of glass-ionomer bone cements conducted at the School of Clinical Dentistry led directly to the start-up of a UK company to manufacture a new medical device, creating jobs in the supply chain and wealth creation via international sales. The new bone cement is safe and clinically effective, and has maintained or restored hearing to improve the quality of life of over 10,000 patients worldwide since 1st January 2008. In the course of supporting this commercial partner, Sheffield's staff also contributed to other non-academic tasks.
Wilkinson has developed, evaluated and applied techniques, standards and datasets for facial depiction and identification of the dead. The impacts include:
Dr Dickinson (Bioengineering) collaborated with Professor Habib (Surgery) to develop novel methods for removing or starving tumours. Resection (removing part of an organ) is theoretically an ideal method for treating liver cancer as the liver can regenerate, but it causes extensive blood loss. The Bioengineering team developed a bipolar electrode system that employs RF current to coagulate a track in the liver; the track can then be cut without bleeding. Prototypes were successfully tested in pre-clinical and clinical trials. 20,000 single-use devices (value: US$40M) have been sold under licence by AngioDynamics, with an estimated saving of >800 lives. Complications, intensive care, blood transfusions, and hospital stay have also been dramatically reduced. Dickinson developed further bipolar devices for maintaining the patency of ducts during pancreatic and biliary cancers, for ablating liver tumours and for blocking tumour blood supply. Sold by Imperial spin-out Emcision, these are also in current clinical use.
Research in the area of mobile digital storytelling conducted at Swansea University has shown that hundreds of millions of people are disempowered by lack of appropriate digital devices, services and infrastructure. In a programme of research starting with real users in communities in rural India, Southern Africa and rural UK, we designed, developed and tested new systems, leading to the integration and delivery of new techniques and platforms by major service providers, including IBM. Open source software developed to simplify media creation and sharing is being used by communities around the world, and has been downloaded more than 14,000 times. The research has increased awareness of "digital divide" issues and has changed attitudes in technology companies and public audiences.
Research at the University of Leeds led to the development of UltraCane — an ultrasonic cane for people who are visually-impaired that gives tactile feedback to the user's hand with progressive non-contact warning of obstacles (ground-to-head) up to 4 m. [text removed for publication]. Testimonials from users describe its transformative nature on their quality of life, giving `a true feeling of independence', whilst healthcare professionals commend `the simplicity of operation and ease of use'. Furthermore, with a technology mimicking bat echolocation, the UltraCane has informed and engaged the wider public in science and engineering through, for example, the BBC `Miracles of Nature' series. The technology has also been developed to allow people who are visually-impaired to cycle independently and safely around a cycle track — the `UltraBike'.
Genetic skeletal diseases (GSDs) are an extremely diverse and complex group of genetic diseases that affect the development of the skeleton. Although individually rare, as a group of related genetic diseases they have an overall prevalence of at least 1 per 4,000 children, which extrapolates to a minimum of 225,000 people in the European Union. This burden in pain and disability leads to poor quality of life and high healthcare costs. GSDs are difficult diseases to diagnose and there are currently no treatments, therefore, arriving at a confirmed diagnosis is vital for clinical management, psycho-social support and genetic counselling.
Research conducted at the University of Manchester (UoM) has had a major influence on establishing the correct diagnosis of specific GSDs by the discovery of causative genes and mutations and the subsequent development of accurate and reliable DNA testing protocols. This has significantly improved both accuracy of, and access to, genetic testing in the UK, Europe and worldwide.
BU economic modelling research has driven increased profits for leading international consultants Maxwell Stamp PLC, to the tune of £12 million to date. Simultaneously, the research has benefited the company's clients, including several governments. For example, the research was used to provide advice critical in helping Namibia safeguard revenues of US$700 million annually from the Southern African Customs Union (SACU).
Independent of Maxwell Stamp, the same techniques have been used to strengthen the research capabilities of the Institute for Scientific Research on Economic Reforms, Azerbaijan. This has been integral in the successful development of new, internationally competitive industries and the World Bank naming Azerbaijan one of the top 10 economic reformers.