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Edinburgh Designs Ltd., (EDL) was spun-out to exploit ERPE research from the original Wave Power Group. With six staff and an annual turnover approaching £2M EDL has supplied the equipment and control systems for wave tanks in 19 countries including the world's largest computer-controlled wave test facility, the US Navy Manoeuvring and Station Keeping Tank. They are currently completing the world's first circular tank, combining waves with currents in any relative direction, which is operated by the 6 person company, "FloWave" EDL, still run by the founding staff, it is the world-leading supplier of wave-making technology for scientific and recreational facilities.
The Africa in Motion Film Festival (AiM), based in Glasgow and Edinburgh, directly emerged from research led by David Murphy and a community of postgraduate students at the University of Stirling. The festival has attracted new audiences for African cinema (over 20,000 spectators since 2006) and contributed to wider debates about it amongst the general public, NGOs, as well as cinephiles in Scotland and more widely. In particular, two projects on the `lost classics' of African cinema allowed neglected films to be discovered both by a general audience and influential film critics/journalists.
African Wild Dogs (Lycaon pictus; referred to as `AWDs' hereafter for brevity) have been classed as endangered by the International Union for Conservation of Nature (IUCN) for 22 years. Large, well-managed captive breeding programmes provide a safety net to restore wild populations. However, the management of the AWD population has been difficult owing to an incomplete family record of captive AWDs, which risks introducing genetic disorders caused by inbreeding. A genetically informed management plan developed by University of Glasgow researchers has provided a genetic measure of diversity and establishes a genetically informed pedigree, which is used in the European Endangered Species Programme for African Wild Dogs. This has introduced a more informed means to manage the captive AWD population, to maintain the genetic diversity of the species across the European zoo network (roughly half the world's captive AWD population), with 53 zoos in 16 European countries (and Israel) currently participating.
Impact: EaStCHEM spin out Albachem (1994), subsequently incorporated into the Almac group, enabling the latter company to become a world leader in the provision of chemically synthesised proteins.
Significance: Chemical synthesis is competitive with recombinant methods for commercial production of the therapeutic polypeptides that represent ~50% of drugs in big pharma pipelines and have a market value in 2008 of over $13B. The value attributable to Ramage's methods for polypeptide syntheses over the REF period is estimated at approximately £6M.
Beneficiaries: Drug manufacturers, contract research organisations, patients, clinicians.
Research: Studies (1993-6) led by Ramage (at the University of Edinburgh) on new methods for high-yield total syntheses and purification of long polypeptides.
Reach: Almac's protein-manufacturing team remains in the UK with 24 staff members. The Almac Group, headquartered in N. Ireland, has 3300 employees globally (1300 outside UK) and sells to 600 companies worldwide.
Our research on alternatives to medication in the treatment of childhood epilepsy has resulted in increasing rates of surgery with better outcomes, and a new clinical service — the national Children's Epilepsy Surgery Service (CESS) — being commissioned in England and Wales. We have also developed an evidence base for ketogenic dietary therapy, resulting in an increase in service provision. Many more patients are benefiting from this therapy, which is now recommended in NICE guidelines. Throughout our programme of research we have engaged with charities and patient groups to disseminate the results of our research as widely as possible.
One of the world-leading systems for large-vocabulary Automatic Speech Recognition (ASR) has been developed by a team led from the University of Sheffield. This system, which won the international evaluation campaigns for rich speech transcription organised by the US National Institute for Standards and Technology (NIST) in 2007 and 2009, has led directly to the creation of one spin-out, been largely instrumental in the launch of a second, has had significant impact on the development and growth of three existing companies, and has made highly advanced technology available free for the first time to a broad range of individual and organisational users, with applications including language learning, speech-to-speech translation and access to education for those with reading and writing difficulties.
By ensuring the durability of notable concrete structures in China, such as the Bird's Nest National Stadium Beijing, Dayawan Nuclear Power Station, Harbin-Dalian Railway Bridges, Qingdao Bay Bridge and Beijing-Tianjin Railway Bridges using Autoclam Permeability System and Permit Ion Migration test, developed by Queen's University Belfast (QUB) and sold by a QUB spin-out Amphora Non-destructive Testing Ltd., the savings in future repair costs are estimated to be hundreds of millions of Chinese Yuan (RMB) (the repair expenditure for the three-year period 2009-'11 was RMB 10.2 billion).
Research on permeability and diffusivity testing of concrete on site since 1993 has led to the incorporation of both the Autoclam and the Permit in a corporation standard issued by the Central Research Institute of Building and Construction (CRIBC), China and the test protocol of Permit in a Chinese railway standard.
The training of construction professionals (including more than 200 senior managers from the Chinese construction industry) since 2008 has impacted on improved sales of Autoclam Permeability System and Permit Ion Migration Test, securing around £500k commercial income, and generating new employment in the UK. Since 2008 these test instruments have been sold to 12 countries.
A spin-out company, Contemplate Ltd, is using advanced static analysis technology in global top-ten investment banks and other clients to discover previously undetected defects in enterprise-scale business-critical multi-threaded Java codebases. The impact is in terms of the benefits delivered to Contemplate's clients by this technology and in terms of the formation and growth of Contemplate as an employer and a successful business.
Mathematical models recently developed in York have improved our understanding of the dynamics of marine ecosystems. They underpin paradigm-changing proposals to orient fisheries policy towards a "balanced harvest" and away from the traditional selective harvesting of species and sizes. These proposals have:
The BUGS research project (1999-2007) at Sheffield was the first large-scale study to reveal the importance of domestic gardens for urban biodiversity. The evidence gathered showed, for the first time, that the extent of gardens, their unique features, and the biodiversity they support makes them a nationally important ecological resource, contributing enormously to conservation and human-nature interactions in urban environments. The results were reported in a series of 13 ISI-listed papers, a popular book and two articles in British Wildlife. The research has had impacts across many audiences and applications ranging from evidence for planning policy changes, through the science to support advisory and campaign groups, to informing public awareness of the merits of individual garden management practices. BUGS research has been a key catalyst in the increased recognition of the importance of gardens in supporting urban biodiversity.