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For over 20 years, conclusive evidence has existed that folic acid in early pregnancy prevents spina bifida and related birth defects (collectively known as neural tube defects; NTD), leading to folic acid recommendations for women of reproductive age worldwide. However, translating these recommendations into practice remains a significant challenge. This case study is focussed on identifying and addressing the challenges in implementing current folic acid policy into practice in healthy populations, and in parallel investigating newer roles for folate in preventing disease. Our international outputs to date have provided a scientific foundation for developing evidence-based, sometimes controversial, policy in this area and its translation to consumers.
Building on work which has contributed, via NICE guidance, to £1 billion in annual savings to the NHS in its healthcare provision for osteoporotic fractures in older adults, research at the £14.4 million MRC Lifecourse Epidemiology Unit (LEU), University of Southampton, has inspired the world's first randomised controlled trial of vitamin D supplementation versus placebo in pregnancy. This work was designed to provide a definitive answer to the question of whether supplementing pregnant women with vitamin D leads to increased bone mineral accrual in the offspring. This work has also shaped national and international guidance on vitamin D supplementation both during pregnancy and in older age; Southampton's programme of osteoporosis research has attracted £10 million in research funding from health organisations and the EU.
Use of our new Tandem Mass Spectrometry (MS) technology for measuring 25 Hydroxy Vitamin D (25OHD) has had both major clinical and economic impacts on:
The Brain, Performance and Nutrition Research Centre (BPNRC) has an international reputation for research conducted in collaboration with industry to assess the impact of nutrition and dietary interventions on brain function. Our research benefits our industrial partners financially, in terms of increased product sales, and by providing evidence supporting the introduction of new products that improve consumer wellbeing. This case study focuses on research that supported Bayer to develop successful brands with public health benefits.
This case study illustrates the development of novel research materials designed to improve quality of life and performance in different populations. Impact has been achieved through the use of research findings in professional practice, formulation of health-related policies and in the development of new indicators of health and well-being. RCSEP research has been used by international and national health-service organisations (e.g., European League Against Rheumatism, Evidence NHS), industrial establishments (e.g., ArtEZ Conservatoire, Netherlands; Royal Ballet), national governing bodies (British Heart Foundation), and professional bodies (e.g., Dance UK, International Association of Dance Medicine & Science).
Within the UK Armed Forces, stress fractures during training in military recruits represent the single largest cause of lost duty days, resulting in substantial costs for the Ministry of Defence.
Research by the University of Surrey has established unique associations between physical characteristics, bone health and nutrition on stress fracture incidence during Royal Marine and Royal Air Force recruit training. This has led the MoD to change entry criteria and to update nutritional advice both in training and during deployment for military personnel. The resultant reduction in number of stress fractures has had both economic and health and wellbeing impacts.
The main impact of this work has been to provide an evidence base to inform practice and policy in relation to nutrition and diet. Through our contribution to the international EURRECA Network of Excellence, we have developed resources accessible to international expert panels as they review micronutrient recommendations. In addition, this work has had a significant impact on the formation of two major new initiatives; BOND and Zinc-Net, both of which address global issues relating to zinc deficiency and human health. Our pioneering research activities in Pakistan are helping to transform nutrition support and quality of life in marginalised communities.
Changing global patterns of agricultural production, food availability and processing are having profound impacts on individual food consumption and population health. Thus accurate data on individual food consumption are fundamental for effective planning of agricultural investments and for the implementation of sound public health nutrition policy. Research undertaken at the University of Ulster has demonstrated that mis-reporting in dietary surveys is pervasive and consequently is obscuring diet-health associations. This research has prompted a major paradigm shift in the way public health policy makers interpret dietary intake data.
John Williams and colleagues found that serum homocysteine predicted cognitive decline and predicted the potential for vitamin B12 in treatment of dementia, including Alzheimer's Disease. This finding has led to the production of 2 novel cobalamin compounds, glutathionyl cobalamin (GSCbl) and N-acetyl cysteinyl cobalamin (NACCbl), in collaboration with Kent State University (USA), the use of which were patented in USA. We have also identified a novel anti-oxidant activity of vitamin B12. This work has led to the production of Betrinac sold by the Chester company, Cobalz Ltd, in the UK and PamLab Llc, USA.